ChemicalBook > CAS DataBase List > Acid-PEG3-t-butyl ester
Acid-PEG3-t-butyl ester
- Product Name
- Acid-PEG3-t-butyl ester
- CAS No.
- 1807539-06-5
- Chemical Name
- Acid-PEG3-t-butyl ester
- Synonyms
- COOH-PEG3-OtBu;Acid-PEG3-C2-Boc;COOH-PEG3-COOtBu;Acid-PEG3-t-Bu Ester;Acid-PEG3-t-butyl ester;HOOCCH2CH2O-PEG2-CH2CH2COOtBu;Carboxy-PEG3-tert-butyl Ester;2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid;4,7,10,14-Tetraoxahexadecanoic acid, 15,15-dimethyl-13-oxo-;3-[2-[2-(3-tert-butoxy-3-oxo-propoxy)ethoxy]ethoxy]propanoic acid
- CBNumber
- CB43062292
- Molecular Formula
- C14H26O7
- Formula Weight
- 306.35
- MOL File
- 1807539-06-5.mol
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Acid-PEG3-t-butyl ester Property
- Boiling point:
- 423.2±35.0 °C(Predicted)
- Density
- 1.106±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in Water, DMSO, DCM, DMF
- pka
- 4.28±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C14H26O7/c1-14(2,3)21-13(17)5-7-19-9-11-20-10-8-18-6-4-12(15)16/h4-11H2,1-3H3,(H,15,16)
- InChIKey
- VDWZJPCGUNJFEE-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCOCCOCCOCCC(=O)OC(C)(C)C
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Safety
- HS Code
- 9999999999
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N-Bromosuccinimide Price
BroadPharm
- Product number
- BP-22143
- Product name
- Acid-PEG3-t-butylester
- Purity
- 95%
- Packaging
- 500mg
- Price
- $980
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-22143
- Product name
- Acid-PEG3-t-butylester
- Purity
- 95%
- Packaging
- 1g
- Price
- $1650
- Updated
- 2021/12/16
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Acid-PEG3-t-butyl ester Chemical Properties,Usage,Production
Description
Acid-PEG3-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
Uses
Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].
IC 50
PEGs; Alkyl/ether
References
[1] Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.
[2] Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.
Acid-PEG3-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Acid-PEG3-t-butyl ester manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- COOH-PEG3-COOtBu 1807539-06-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-23
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