ChemicalBook > CAS DataBase List > 4-Methylanisole

4-Methylanisole

Product Name
4-Methylanisole
CAS No.
104-93-8
Chemical Name
4-Methylanisole
Synonyms
MSO;1-METHOXY-4-METHYLBENZENE;P-CRESYL METHYL ETHER;PARA CRESYL METHYL ETHER;P-METHYLANISOLE;4-METHOXYTOLUENE;P-CRESOL METHYL ETHER;Benzene,1-methoxy-4-methyl-;FEMA 2681;MSO)4-Methylan
CBNumber
CB0327875
Molecular Formula
C8H10O
Formula Weight
122.16
MOL File
104-93-8.mol
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4-Methylanisole Property

Melting point:
-32°C
Boiling point:
174 °C(lit.)
Density 
0.969 g/mL at 25 °C(lit.)
vapor pressure 
5.25 mm Hg ( 50 °C)
refractive index 
n20/D 1.511(lit.)
FEMA 
2681 | P-METHYLANISOLE
Flash point:
128 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Soluble), Ethyl Acetate (Slightly)
form 
Liquid
color 
Clear colorless to slightly yellow
Odor
at 1.00 % in dipropylene glycol. naphthyl cresol ylang powdery nutty
Odor Type
naphthyl
Odor Threshold
0.0012ppm
biological source
synthetic
explosive limit
1.1-8.3%(V)
Water Solubility 
slightly soluble
λmax
279nm(MeOH)(lit.)
JECFA Number
1243
BRN 
1237336
Dielectric constant
4.0300000000000002
Stability:
Stable. Incompatible with strong oxidizing agents. Combustible.
LogP
2.74-2.8 at 25-35℃
CAS DataBase Reference
104-93-8(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, 1-methoxy-4-methyl-(104-93-8)
EPA Substance Registry System
p-Methylanisole (104-93-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-38-10-52/53-63
Safety Statements 
36/37-16-61
RIDADR 
UN 1993 3/PG 3
WGK Germany 
1
RTECS 
BZ8780000
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29093090
Hazardous Substances Data
104-93-8(Hazardous Substances Data)
Toxicity
The acute oral LD50 in rats was reported as 1.92 (1.51-2.45) g/kg (Hart, 1971). The acute dermal LD50 in rabbits was reported as > 5 g/kg (Hart, 1971).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H361Suspected of damaging fertility or the unborn child

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
148091
Product name
4-Methylanisole
Purity
99%
Packaging
100ml
Price
$25.5
Updated
2024/03/01
Sigma-Aldrich
Product number
148091
Product name
4-Methylanisole
Purity
99%
Packaging
1l
Price
$157
Updated
2024/03/01
TCI Chemical
Product number
M0149
Product name
4-Methoxytoluene
Purity
>98.0%(GC)
Packaging
25mL
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
M0149
Product name
4-Methoxytoluene
Purity
>98.0%(GC)
Packaging
100mL
Price
$28
Updated
2024/03/01
Alfa Aesar
Product number
A11572
Product name
4-Methylanisole, 99%
Packaging
500ml
Price
$63.65
Updated
2024/03/01
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4-Methylanisole Chemical Properties,Usage,Production

Description

p-Methylanisole has a pungent odor suggestive of ylang-ylang. May be prepared by methylation of p-cresol.

Chemical Properties

p-Methylanisole has a pungent odor suggestive of ylang-ylang.

Chemical Properties

colourless liquid

Occurrence

Reported found in the oils of ylang-ylang, cananga and flowers of Mimusops elengi L. Also reported found in tomato, blue and Camembert cheese, starfruit, buckwheat, rooibus tea (Aspalathus linearis) and tapereba (Spondias lutea).

Uses

4-Methylanisole was used to prepare 5-methoxy-1,8-dimethyltetralin. It was also used as the solubilizate molecule to study the site of incorporation of solubilizates in sodium dodecyl sulfate (SDS) micellar systems.

Uses

4-Methylanisole may be used as an analytical standard for the determination of the analyte in Malus taxa flowers, coffee brews, aqueous matrices, food products, and Ficus semicordata by various chromatography techniques.

Uses

Perfumery, flavoring.

Preparation

By methylation of p-cresol.

Definition

ChEBI: 1-Methoxy-4-methylbenzene is a member of methoxybenzenes.

Aroma threshold values

Detection: 200 ppb

Taste threshold values

Taste characteristics at 20 ppm: naphthyl, phenolic, camphoraceous, cooling and woody.

Synthesis Reference(s)

Journal of the American Chemical Society, 113, p. 8516, 1991 DOI: 10.1021/ja00022a046
Tetrahedron Letters, 32, p. 2759, 1991 DOI: 10.1016/0040-4039(91)85078-J
The Journal of Organic Chemistry, 59, p. 4687, 1994 DOI: 10.1021/jo00095a054

General Description

4-Methylanisole is an odorant benzenoid belonging to the group of volatile organic compounds (VOCs). It can contribute to the floral scent of the plants. 4-Methylanisole is typically a lignin-derived bio-oil that is also a major ingredient of certain food products.

Safety Profile

Moderately toxic by ingestion. A skin irritant. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Dissolve 4-methyl anisole in diethyl ether, wash it with M NaOH, water, dry (Na2CO3), evaporate and distil it under vacuum. The picrate has m 103o (from aqueous EtOH). [Beilstein 6 IV 2098.]

4-Methylanisole Preparation Products And Raw materials

Raw materials

p-Cresol 2-Methylanisole

Preparation Products

Acid Orange 156 2-Methoxy-5-methylaniline VESNARINONE p-Anisaldehyde
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4-Methylanisole Suppliers

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View Lastest Price from 4-Methylanisole manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-Methylanisole 104-93-8
Price
US $55.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-26
airuikechemical co., ltd.
Product
4-methylanisole 104-93-8
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.99%
Supply Ability
200tons
Release date
2024-04-07
Hebei Yanxi Chemical Co., Ltd.
Product
4-Methylanisole 104-93-8
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-09

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