ChemicalBook > CAS DataBase List > N-Boc-PEG4-bromide

N-Boc-PEG4-bromide

Product Name
N-Boc-PEG4-bromide
CAS No.
1392499-32-9
Chemical Name
N-Boc-PEG4-bromide
Synonyms
BocNH-PEG4-Br;Br-PEG4-NHBoc;N-Boc-PEG4-bromide;N-Boc-PEG5-bromide;BocNH-PEG4-CH2CH2Br;N-Boc-PEG4-bromide N-Boc-;tert-butyl (14-bromo-3,6,9,12-tetraoxatetradecyl)carbamate;tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate;5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester;tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate - [B82697]
CBNumber
CB03373736
Molecular Formula
C15H30BrNO6
Formula Weight
400.31
MOL File
1392499-32-9.mol
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N-Boc-PEG4-bromide Property

Boiling point:
459.3±40.0 °C(Predicted)
Density 
1.223±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
solubility 
Soluble in DCM
pka
12.23±0.46(Predicted)
form 
Liquid
color 
Light yellow to brown
InChI
InChI=1S/C15H30BrNO6/c1-15(2,3)23-14(18)17-5-7-20-9-11-22-13-12-21-10-8-19-6-4-16/h4-13H2,1-3H3,(H,17,18)
InChIKey
KYOVSWOWVSWAII-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NCCOCCOCCOCCOCCBr
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-23789
Product name
N-Boc-PEG4-bromide
Purity
98%
Packaging
250mg
Price
$540
Updated
2021/12/16
Activate Scientific
Product number
AS103627
Product name
BocNH-PEG4-CH2CH2Br
Purity
95+%
Packaging
1g
Price
$665
Updated
2021/12/16
AK Scientific
Product number
0954EB
Product name
N-Boc-PEG5-bromide
Packaging
1g
Price
$856
Updated
2021/12/16
Acrotein
Product number
AC-8220
Product name
BocNH-PEG4-CH2CH2Br
Purity
97%
Packaging
0.25g
Price
$220
Updated
2021/12/16
Crysdot
Product number
CD64000172
Product name
N-BOc-peg4-bromide
Purity
95%
Packaging
250mg
Price
$270
Updated
2021/12/16
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N-Boc-PEG4-bromide Chemical Properties,Usage,Production

Description

N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Biological Activity

N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

N-Boc-PEG4-bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-PEG4-bromide Suppliers

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View Lastest Price from N-Boc-PEG4-bromide manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Br-PEG4-NHBoc 1392499-32-9
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-25

1392499-32-9, N-Boc-PEG4-bromideRelated Search:

1,14-DIBROMO-3,6,9,12-TETRAOXATETRADECANE NA 1-Bromobutane Sulfanilamide N-ACETYLLACTOSAMINE 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol t-Boc-N-amido-PEG5-acid O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) N-Boc-PEG5-alcohol Biotin-PEG36-PFP ester N-(Amino-PEG3)-N-bis(PEG4-Boc) BocNH-PEG5-acid Biotin-PEG6-t-butyl ester FMOC-18-AMINO-4,7,10,13,16-PENTAOXAOCTADECANOIC ACID 2-[2-[2-T-BOC-AMINOETHOXY]ETHOXY]ETHYL BROMIDE t-Boc-Aminooxy-PEG2-CH2CO2H N-(Amino-PEG4)-N-bis(PEG4-t-butyl ester) Mal-amido-PEG7-acid

  • N-Boc-PEG4-bromide
  • BocNH-PEG4-CH2CH2Br
  • N-Boc-PEG5-bromide
  • Br-PEG4-NHBoc
  • 5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester
  • tert-butyl (14-bromo-3,6,9,12-tetraoxatetradecyl)carbamate
  • ADC,antibody-drug,PROTAC Linkers,ADC Linkers,N-Boc-PEG-5-bromide,cleavable,inhibit,conjugates,Inhibitor,N Boc PEG5 bromide,NBocPEG5bromide,Antibody-drug conjugates linkers
  • tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate
  • N-Boc-PEG4-bromide N-Boc-
  • BocNH-PEG4-Br
  • tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate - [B82697]
  • 1392499-32-9
  • C15H30BrNO6