N-Boc-PEG4-bromide

ChemicalBook > CAS DataBase List > N-Boc-PEG4-bromide

Product Name: N-Boc-PEG4-bromide
CAS No.: 1392499-32-9
Chemical Name: N-Boc-PEG4-bromide
Synonyms: BocNH-PEG4-Br;Br-PEG4-NHBoc;N-Boc-PEG4-bromide;N-Boc-PEG5-bromide;BocNH-PEG4-CH2CH2Br;N-Boc-PEG4-bromide N-Boc-;tert-butyl (14-bromo-3,6,9,12-tetraoxatetradecyl)carbamate;tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate;5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester;ADC,antibody-drug,PROTAC Linkers,ADC Linkers,N-Boc-PEG-5-bromide,cleavable,inhibit,conjugates,Inhibitor,N Boc PEG5 bromide,NBocPEG5bromide,Antibody-drug conjugates linkers
CBNumber: CB03373736
Molecular Formula: C15H30BrNO6
Formula Weight: 400.31
MOL File: 1392499-32-9.mol

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N-Boc-PEG4-bromide Property

Boiling point:: 459.3±40.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
solubility: Soluble in DCM
pka: 12.23±0.46(Predicted)
form: Liquid
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23789
Product name: N-Boc-PEG4-bromide
Purity: 98%
Packaging: 250mg
Price: $540
Updated: 2021/12/16

Activate Scientific

Product number: AS103627
Product name: BocNH-PEG4-CH2CH2Br
Purity: 95+%
Packaging: 1g
Price: $665
Updated: 2021/12/16

AK Scientific

Product number: 0954EB
Product name: N-Boc-PEG5-bromide
Packaging: 1g
Price: $856
Updated: 2021/12/16

Crysdot

Product number: CD64000172
Product name: N-BOc-peg4-bromide
Purity: 95%
Packaging: 1g
Price: $600
Updated: 2021/12/16

Acrotein

Product number: AC-8220
Product name: BocNH-PEG4-CH2CH2Br
Purity: 97%
Packaging: 0.25g
Price: $220
Updated: 2021/12/16

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N-Boc-PEG4-bromide Chemical Properties,Usage,Production

Description

N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Biological Activity

N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

N-Boc-PEG4-bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N-Boc-PEG4-bromide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Br-PEG4-NHBoc 1392499-32-9
Price: US $0.00/g
Min. Order: 5g
Purity: >98.00%
Supply Ability: 5g
Release date: 2024-03-25

1392499-32-9, N-Boc-PEG4-bromideRelated Search:

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N-Boc-PEG4-bromide

BocNH-PEG4-CH2CH2Br

N-Boc-PEG5-bromide

Br-PEG4-NHBoc

5,8,11,14-Tetraoxa-2-azahexadecanoic acid, 16-bromo-, 1,1-dimethylethyl ester

tert-butyl (14-bromo-3,6,9,12-tetraoxatetradecyl)carbamate

ADC,antibody-drug,PROTAC Linkers,ADC Linkers,N-Boc-PEG-5-bromide,cleavable,inhibit,conjugates,Inhibitor,N Boc PEG5 bromide,NBocPEG5bromide,Antibody-drug conjugates linkers

tert-butyl N-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate

N-Boc-PEG4-bromide N-Boc-

BocNH-PEG4-Br

1392499-32-9

C15H30BrNO6