ChemicalBook > CAS DataBase List > 2-Acetamidophenol

2-Acetamidophenol

Product Name
2-Acetamidophenol
CAS No.
614-80-2
Chemical Name
2-Acetamidophenol
Synonyms
NSC 398;NSC 3989;2-Acetamino;AKOS BBB/377;O AcetaMinophen;acetoaminophenol;O-ACETAMINOPHENOL;O-ACETAMIDOPHENOL;2-ACETAMIDOPHENOL;2-acetamido-pheno
CBNumber
CB0342159
Molecular Formula
C8H9NO2
Formula Weight
151.16
MOL File
614-80-2.mol
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2-Acetamidophenol Property

Melting point:
205-210 °C(lit.)
Boiling point:
273.17°C (rough estimate)
Density 
1.2023 (rough estimate)
refractive index 
1.5810 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder
pka
9.35±0.35(Predicted)
color 
Off-white to beige to brown
BRN 
607592
Stability:
Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.
InChI
InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)
InChIKey
ADVGKWPZRIDURE-UHFFFAOYSA-N
SMILES
C(NC1=CC=CC=C1O)(=O)C
CAS DataBase Reference
614-80-2(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, N-(2-hydroxyphenyl)-(614-80-2)
EPA Substance Registry System
2'-Hydroxyacetanilide (614-80-2)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/38-22-36/37/38
Safety Statements 
26-36-37/39
RIDADR 
2811
WGK Germany 
3
RTECS 
AE4025000
F 
1-8
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29242995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A7000
Product name
2-Acetamidophenol
Purity
97%
Packaging
25g
Price
$48.7
Updated
2024/03/01
Sigma-Aldrich
Product number
A7000
Product name
2-Acetamidophenol
Purity
97%
Packaging
100g
Price
$90.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1003031
Product name
Acetaminophen Related Compound C
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
50mg
Price
$1380
Updated
2024/03/01
TCI Chemical
Product number
H0189
Product name
2'-Hydroxyacetanilide
Purity
>99.0%(HPLC)(N)
Packaging
25g
Price
$68
Updated
2024/03/01
Alfa Aesar
Product number
B21264
Product name
2-Acetamidophenol, 97%
Packaging
25g
Price
$22.65
Updated
2024/03/01
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2-Acetamidophenol Chemical Properties,Usage,Production

Chemical Properties

white or light brown powder.soluble in hot water and ethanol, slightly soluble in cold water.

Uses

An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis.

Definition

ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.

Preparation

Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.]

2-Acetamidophenol Preparation Products And Raw materials

Raw materials

2-Aminophenol

Preparation Products

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2-Acetamidophenol Suppliers

Americas 1 Belgium 1 Canada 2 China 220 Europe 4 Germany 5 India 41 Japan 5 Russia 1 Slovakia 1 Switzerland 2 United Kingdom 18 United States 37 Global 338
Pushan Industry (Shaanxi) Co., Ltd.
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View Lastest Price from 2-Acetamidophenol manufacturers

Apeloa production Co.,Limited
Product
acetoaminophenol 614-80-2
Price
US $1.00/g
Min. Order
1g
Purity
0.98
Supply Ability
1000
Release date
2024-07-19
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
2-Acetamidophenol 614-80-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2-5 MTs
Release date
2024-05-11
Hebei Weibang Biotechnology Co., Ltd
Product
2-Acetamidophenol 614-80-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-11

614-80-2, 2-AcetamidophenolRelated Search:

4'-Aminoacetanilide 4'-Nitroacetanilide Acetamide 4-Hydroxyaniline hydrochloride 3-Diethylaminophenol p-Acetotoluidide 2-BENZOYLACETANILIDE 2-ACETAMIDOFLUORENE 4-Aminophenol 2-Aminophenol 2-Chloro-4-acetamidophenol ACETAMINOPHEN IMPURITY B 4'-CHLOROACETANILIDE 4-[1-(hydroxyamino)ethylidene]cyclohexa-2,5-dien-1-one 4,4'-Iminodiphenol hydrochloride 4'-Hydroxyacetophenone 2'-Hydroxyacetophenone 4-Acetoxyacetanilide

  • 2-ACETYLAMINOPHENOL
  • 2-ACETAMIDOPHENOL
  • 2-ACETAMINO PHENOL
  • Acetaminophen Related Compound C (50 mg) (N-(2-hydroxyphenyl)acetamide)
  • AKOS BBB/377
  • O-HYDROXYACETANILIDE
  • O-ACETAMIDOPHENOL
  • O-ACETAMINOPHENOL
  • N-(2-Hydroxyphenyl)acetamide
  • 2'-HYDROXYACETANILIDE
  • 2-HYDROXYACETANILIDE
  • 2’-hydroxy-acetanilid
  • 2-acetamido-pheno
  • 2-Hydroxyanilid kyseliny octove
  • 2-hydroxyanilidkyselinyoctove
  • Acetanilide, 2'-hydroxy-
  • Acet-o-aminofenol
  • n-(2-hydroxyphenyl)-acetamid
  • N-(2-hydroxyphenyl)ethanamide
  • N-Acetyl-2-aminophenol
  • N-Acetyl-o-aminophenol
  • o-(Acetylamino)phenol
  • o-Acetylaminofenol
  • Phenol, 2-acetamido-
  • Paracetamol EP Impurity A(2-Acetamidophenol)
  • 2-Acetamidophenol99%
  • 2-Acetamidophenol,97%
  • 2-(N-Acetylamino)phenol
  • NSC 398
  • 2-Acetamino
  • o-Acetamidophenol AP
  • ORTHO-HYDROXYACETANILIDE
  • 2-HYDROXYACETANILIDE / 2-ACETAMIDOPHENOL
  • NSC 3989
  • o-Aminophenol N-acetate
  • 2-Acetamide phenol
  • O AcetaMinophen
  • ParacetaMol IMpurity A
  • 2-AcetaMidophenol, 98.5%
  • AcetaMinophen Related CoMpound C
  • Paracetamol EP Impurity A
  • Paracetamol Impurity 1(Paracetamol EP Impurity A)
  • 2'-Hydroxyacetanilide&gt
  • N-(2-Hydroxyphenyl)acetamide (2-Ace
  • Acetamide, N-(2-hydroxyphenyl)-
  • acetoaminophenol
  • Paracetamol(Acetaminophen) EP Impurity A
  • Paracetamol EP Impurity
  • Acetaminophen related compound C Paracetamol Impurity A
  • Acetaminophen impurities1455
  • Acetaminophen EP Impurity A
  • Acetaminophen Related Compound C (R00920)
  • Acetaminophen Related Compound C (N-(2-hydroxyphenyl)acetamide) (1003031)
  • Acetaminophen USP Related Compound C
  • 2 Acetamidophenol,2Acetamidophenol
  • 2'-Hydroxyacetanilide, ≥ 99.0%
  • Acetaminophene Related Compound C
  • PARACETAMOL EP IMP A/Acetaminophen USP RC C