ChemicalBook > CAS DataBase List > Boc-His(Trt)-OH

Boc-His(Trt)-OH

Product Name
Boc-His(Trt)-OH
CAS No.
32926-43-5
Chemical Name
Boc-His(Trt)-OH
Synonyms
BOC-HIS(TRT)-OH;Boc-His(trt);His(Trt)-OH;BOC-L-HIS(TRT)-OH;Boc-L-His(Trt);Impurity HA-1;N-Boc-His(Trt)-OH;(S)-L-Boc-his(trt)-oh;Boc-His(Trt)-OH, >=98%;BOC-N-IM-TRITYL-L-HISTIDINE
CBNumber
CB0342634
Molecular Formula
C30H31N3O4
Formula Weight
497.58
MOL File
32926-43-5.mol
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Boc-His(Trt)-OH Property

Melting point:
~130 °C (dec.)
alpha 
12.5 º (C=1% IN MEOH)
Boiling point:
667.5±55.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Sparingly)
form 
Solid
pka
3.17±0.10(Predicted)
color 
White to Off-White
optical activity
[α]20/D +12.5±1.0°, c = 1% in methanol
BRN 
732035
InChIKey
OYXZPXVCRAAKCM-SANMLTNESA-N
SMILES
C(O)(=O)[C@H](CC1N=CN(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=1)NC(OC(C)(C)C)=O
CAS DataBase Reference
32926-43-5(CAS DataBase Reference)
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Safety

WGK Germany 
3
HS Code 
29224999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53034
Product name
Boc-His(Trt)-OH
Purity
Novabiochem?
Packaging
25g
Price
$1340
Updated
2024/03/01
Sigma-Aldrich
Product number
15449
Product name
Boc-His(Trt)-OH
Purity
≥98.0% (TLC)
Packaging
1g
Price
$42.8
Updated
2024/03/01
TRC
Product number
B656218
Product name
Boc-His(Trt)-OH
Packaging
5g
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB42925
Product name
Boc-His(Trt)-OH
Packaging
10g
Price
$90
Updated
2021/12/16
Chem-Impex
Product number
04038
Product name
Nα-Boc-Nim-trityl-L-histidine,≥99.7%(HPLC,Chiralpurity)
Purity
≥99.7%(HPLC,Chiralpurity)
Packaging
5G
Price
$93.18
Updated
2021/12/16
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Boc-His(Trt)-OH Chemical Properties,Usage,Production

Chemical Properties

White to off white powder

Uses

Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.

Uses

Boc-His(Trt)-OH is a histidine derivative. Its a protected histidine derivative for only the critical coupling step. After coupling the Boc- and Trt-groups are cleaved simultaneously by TFA.

Preparation

The benzyl 2-tert-butoxycarbonylamino-3-(1-trimethylimidazol-4-yl)propionate was dissolved in methanol (20 mL), and potassium hydroxide was added to the reaction system. The reaction system was stirred for 1 h after THF was added to the reaction system. The solvent is removed under vacuum depressurization, and the mixture is then extracted with water and Et2O. Separate the two phases and acidify the aqueous layer with dilute HCl, extract it with Et2O, combine all the ether organic layer and wash it with water and saline, dry the organic layer with anhydrous magnesium sulfate, filter to remove the solvent, and concentrate the filtrate under vacuum under reduced pressure to obtain Boc-His(Trt)-OH.

Application

N-Boc-N'-Trityl-L-histidine (Boc-His(Trt)-OH) can be used as an intermediate in biochemistry and medicinal chemistry and can be used in the synthesis of peptide drug molecules, vitamins, and molecules with specific biologically active functions. In organic synthesis transformation, the carboxyl group in N-Boc-N'-trityl-L-histidine can undergo corresponding condensation reactions with amine compounds to obtain the corresponding amide products; in addition, in dithionyl chloride Under the action of N-Boc-N'-trityl-L-histidine, intramolecular dehydration cyclization reaction can be performed to obtain cyclic amide derivatives.

reaction suitability

Reaction type: Boc solid-phase peptide synthesis

Boc-His(Trt)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-His(Trt)-OH Suppliers

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View Lastest Price from Boc-His(Trt)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-His(trt)-OH 32926-43-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%;99%
Supply Ability
1T+
Release date
2024-02-23
Henan Fengda Chemical Co., Ltd
Product
Boc-His(Trt)-OH 32926-43-5
Price
US $8.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-23
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-Boc-N"-trityl-L-histidine 32926-43-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

32926-43-5, Boc-His(Trt)-OHRelated Search:

Trityl candesartan cilexetil p-Toluic acid L-Histidine N-Boc-L-Histidine N-Carbobenzyloxyglycine Triphenylmethyl Chloride PENICILLIN V Boc-Aib-OH N-Boc-N'-Cbz-L-lysine N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol Boc-D-Ser(Bzl)-OH N-BOC-O-Benzyl-L-serine BOC-GLY-LEU-OH Toluene (-)-2-[METHYLAMINO]-1-PHENYLPROPANE 1-Triphenylmethyl-4-methylimidazole BOC-HIS(BZL)-OH H-HIS(BZL)-OH

  • (S)-2-(tert-butoxycarbonylamino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid
  • (2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
  • Nα-(tert-butyloxy)carbonyl-Nim-triphenylmethyl-L-histidine
  • Boc-L-His(Trt)
  • N-Boc-His(Trt)-OH
  • (S)-2-(Boc-aMino)-3-(1-trityl-4-iMidazolyl)propionic acid, 95%
  • His(Trt)-OH
  • Boc-His(Trt)-OH >=98.0% (TLC)
  • Boc-His(Trt)-OH, >=98%
  • (S)-L-Boc-his(trt)-oh
  • BOC-L-HIS(TRT)-OH
  • BOC-N-IM-TRITYL-L-HISTIDINE
  • BOC-HIS(TRT)-OH
  • N-T-BUTOXYCARBONYL-N-TAU-TRITYL-L-HISTIDINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-N-IM-TERT-TRITYL-L-HISTIDINE
  • N-ALPHA-T-BOC-N-IM-TRITYL-L-HISTIDINE
  • N-ALPHA-BOC-N-(IM)-TRITYL-L-HISTIDINE
  • N<sub>α</sub>-Boc-N(im)-trityl-L-histidine
  • Boc-His(trt)
  • N-ALPHA-T-BUTYLOXYCARBONYL-N-IM-T-TRITY-L-HISTIDINE
  • L-HISTIDINE, N-[(1,1-DIMETHYLETHOXY)CARBONYL]-1-(TRIPHENYLMETHYL)-
  • Nα-Boc-Nim-trityl-L-histidine≥ 99.7% (HPLC, Chiral purity)
  • N-Boc-N'-trityl-L-histidine
  • (Tert-Butoxy)Carbonyl His(Trt)-OH
  • 2-((TERT-BUTOXYCARBONYL)AMINO)-3-(1-TRITYL-1H-IMIDAZOL-4-YL)PROPANOIC ACID
  • N-Boc-N'-trityl-L-histidine USP/EP/BP
  • Nα-Boc-Nim-trityl-L-histidine
  • N-[(1,1-Dimethylethoxy)carbonyl]-1-(triphenylmethyl)-L-histidine
  • (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(1-tritylimidazol-4-yl)propanoic acid
  • N-Boc N '- Triphenylmethyl L-histidine
  • Na-(tert-butoxycarbonyl)-N-trityl-L-histidine
  • N-Boc-N'-trityl-L-histidine
  • Impurity HA-1
  • N-Boc-N'-triphenylmethyl-L-histidine
  • 32926-43-5
  • C30H31N3O4
  • Amino Acid Derivatives
  • Histidine
  • Peptide Synthesis
  • Specialty Synthesis
  • Boc-Amino Acids and Derivative
  • Boc-Amino acid series