ChemicalBook > CAS DataBase List > 6-Chloroindole-2-carboxylic acid ethyl ester

6-Chloroindole-2-carboxylic acid ethyl ester

Product Name
6-Chloroindole-2-carboxylic acid ethyl ester
CAS No.
27034-51-1
Chemical Name
6-Chloroindole-2-carboxylic acid ethyl ester
Synonyms
SPECS AP-283/40634148;6-CHLORO-2-INDOLECARBOXYLIC;Ethyl 6-chloroindole-2-carboxylate;Ethyl 6-Chloroindole-2-Carboxylicate;Ethyl 6-chloro-1H-indole-2-caboxylate;Ethyl6-chloroindole-2-carboxylate,97%;Ethyl 6-chloro-1H-indol-2-carboxylate;ETHYL 6-CHLORO-1H-INDOLE-2-CARBOXYLATE;6-CHLORO-2-INDOLECARBOXYLIC METHYL ESTER;6-Chlor-indol-2-carbonsaeure-aethylester
CBNumber
CB0342977
Molecular Formula
C11H10ClNO2
Formula Weight
223.66
MOL File
27034-51-1.mol
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6-Chloroindole-2-carboxylic acid ethyl ester Property

Melting point:
169-171 °C
Boiling point:
375.0±22.0 °C(Predicted)
Density 
1.329±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
Solid
pka
14.11±0.30(Predicted)
Appearance
Light brown to gray Solid
CAS DataBase Reference
27034-51-1(CAS DataBase Reference)
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C380800
Product name
6-Chloroindole-2-carboxylicacidethylester
Packaging
250mg
Price
$55
Updated
2021/12/16
TRC
Product number
C380800
Product name
6-Chloroindole-2-carboxylicacidethylester
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
073585
Product name
Ethyl 6-chloroindole-2-carboxylate
Purity
95+%
Packaging
1g
Price
$22
Updated
2021/12/16
Matrix Scientific
Product number
073585
Product name
Ethyl 6-chloroindole-2-carboxylate
Purity
95+%
Packaging
5g
Price
$68
Updated
2021/12/16
Matrix Scientific
Product number
073585
Product name
Ethyl 6-chloroindole-2-carboxylate
Purity
95+%
Packaging
25g
Price
$240
Updated
2021/12/16
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6-Chloroindole-2-carboxylic acid ethyl ester Chemical Properties,Usage,Production

Uses

Ethyl 6-chloroindole-2-carboxylate is an organic compound mainly used as a pharmaceutical intermediate and chemical reagent.

Synthesis

24513-05-1

27034-51-1

General method: 6a-d (9.2 mmol) was dissolved in toluene (150 mL) under nitrogen protection, rhodium(II) acetate dimer (203 mg, 0.46 mmol) was added, and the reaction was heated to reflux for 1-2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, 25:1 to 18:1, v/v) to afford the target product ethyl 6-chloroindole-2-carboxylate (7a-d) in 51.7%-58.6% overall yields.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 6, p. 1760 - 1762
[2] Journal of Medicinal Chemistry, 1991, vol. 34, # 4, p. 1283 - 1292

6-Chloroindole-2-carboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Ethanol Diethyl oxalate Diethyl ether Hydrochloric acid Acetic acid Potassium 4-Chloro-2-nitrotoluene

Preparation Products

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View Lastest Price from 6-Chloroindole-2-carboxylic acid ethyl ester manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
6-Chloroindole-2-carboxylic acid ethyl ester 27034-51-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
6-Chloroindole-2-carboxylic acid ethyl ester 27034-51-1
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000KGS
Release date
2020-01-14

27034-51-1, 6-Chloroindole-2-carboxylic acid ethyl esterRelated Search:

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  • SPECS AP-283/40634148
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  • 6-Chloroindole-2-carboxylic acid ethyl ester ,99%
  • 1H-Indole-2-carboxylic acid, 6-chloro-, ethyl ester
  • 6-Chloro-1H-indole-2-carboxylic acid ethyl ester
  • Ethyl 6-chloro-1H-indole-2-caboxylate
  • 6-Chlor-indol-2-carbonsaeure-aethylester
  • 6-chlorindole-2-carboxylic acid ethyl ester
  • Ethyl6-chloroindole-2-carboxylate,97%
  • 1H-Indole-2-carboxylic acid, 6-chloro-, ethyl ester (9CI, ACI)
  • 6-chloro-1H-Indole-2-carboxylic acid ethyl ester (9CI ACI)
  • 6-Chloroindole-2-carboxylic acid ethyl ester?New
  • ETHYL 6-CHLORO-1H-INDOLE-2-CARBOXYLATE
  • Ethyl 6-chloro-1H-indol-2-carboxylate
  • 27034-51-1
  • C11H10ClNO2
  • Indole/indoline/oxindole
  • Indole and Indoline
  • Indole
  • Indoles