ChemicalBook > CAS DataBase List > T0901317

T0901317

Product Name
T0901317
CAS No.
293754-55-9
Chemical Name
T0901317
Synonyms
CS-721;T 1317;T0901317;TO091317;TO-91317;TO-901317;TO 091317;TO-091317;T0901317 (T-1317);T0901317 293754-55-9
CBNumber
CB0368768
Molecular Formula
C17H12F9NO3S
Formula Weight
481.33
MOL File
293754-55-9.mol
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T0901317 Property

Melting point:
116-118°C
Boiling point:
470.5±55.0 °C(Predicted)
Density 
1.550±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Light beige solid
pka
9.00±0.15(Predicted)
color 
Off-White
InChI
InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChIKey
SGIWFELWJPNFDH-UHFFFAOYSA-N
SMILES
C1(S(N(CC(F)(F)F)C2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2)(=O)=O)=CC=CC=C1
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T2320
Product name
T0901317
Purity
≥98%
Packaging
5mg
Price
$93.8
Updated
2025/07/31
Sigma-Aldrich
Product number
T2320
Product name
T0901317
Purity
≥98%
Packaging
10MG
Price
$149
Updated
2025/07/31
Sigma-Aldrich
Product number
575310
Product name
T0901317
Packaging
10mg
Price
$187
Updated
2025/07/31
TCI Chemical
Product number
T4241
Product name
T 0901317
Packaging
50MG
Price
$222
Updated
2025/07/31
Cayman Chemical
Product number
71810
Product name
T0901317
Purity
≥98%
Packaging
10mg
Price
$40
Updated
2024/03/01
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T0901317 Chemical Properties,Usage,Production

Uses

The Liver X Receptors (LXRα and LXRβ) are nuclear hormone receptors whose native ligands are oxysterols, such as 22(R)-hydroxycholesterol. The LXRs regulate the oxysterol-induced expression of cholesterol 7α-hydroxylase, the rate limiting enzyme of classic bile acid synthesis. T0901317 is a potent and selective agonist for both LXRα and LXRβ, with an EC50 of about 50 nM. T0901317 acting through LXR and in concert with its RXR heterodimerization partner induces the expression of the ABCA1 reverse cholesterol transporter. This acts to increase the efflux of cholesterol from enterocytes and thus inhibit the overall absorption of cholesterol.

Uses

T0901317 is a potent and selective agonist for both liver x receptor (LXR) and farnesoid X receptor (FXR).

General Description

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.

Biological Activity

Potent, high affinity liver X receptor (LXR) agonist (EC 50 ~ 50 nM, Kd values are 7 and 22 nM for LXR- α and LRXR- β respectively). Upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism. Decreases amyloid- β production in primary neurons in vitro . Displays an EC 50 of ~ 5 μ M for activation of bile acid farnesoid X receptors (FXRs); 10-fold more potent than natural FXR ligand chenodeoxycholic acid.

Biochem/physiol Actions

Cell permeable: yes

storage

Store at +4°C

References

[1]. schultz j r, tu h, luk a, et al. role of lxrs in control of lipogenesis[j]. genes & development, 2000, 14(22): 2831-2838.
[2]. kumar n, solt l a, conkright j j, et al. the benzenesulfoamide t0901317 [n-(2, 2, 2-trifluoroethyl)-n-[4-[2, 2, 2-trifluoro-1-hydroxy-1-(trifluoromethyl) ethyl] phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-α/γ inverse agonist[j]. molecular pharmacology, 2010, 77(2): 228-236.
[3]. houck k a, borchert k m, hepler c d, et al. t0901317 is a dual lxr/fxr agonist[j]. molecular genetics and metabolism, 2004, 83(1): 184-187.
[4]. liu y, yan c, wang y, et al. liver x receptor agonist t0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice[j]. endocrinology, 2006, 147(11): 5061-5068.

T0901317 Preparation Products And Raw materials

Raw materials

Preparation Products

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T0901317 Suppliers

China 134 Germany 1 India 2 Japan 1 Switzerland 2 United Kingdom 2 United States 17 Global 159
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293754-55-9, T0901317Related Search:

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  • N-(2,2,2-TRIFLUOROETHYL)-N-[4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL]BENZENESULFONAMIDE
  • T0901317
  • TO-901317
  • BenzenesulfonaMide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoroMethyl)ethyl]phenyl]-
  • T 1317
  • T0901317;T 0901317; T-0901317
  • N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]
  • T0901317 - CAS 293754-55-9 - Calbiochem
  • CS-721
  • T0901317 (T-1317)
  • N-(2,2,2-trifluoroethyl)
  • N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-(2,2,2-trifluoroethyl)benzenesulfonamide
  • T0901317 293754-55-9
  • N-(2,2,2-Trifluoroethyl)-N-4-2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethylphenylbenzenesulfonamide
  • TO 091317
  • TO091317
  • TO-091317
  • TO-91317
  • T0901317, LXR agonist
  • T0901317, 10 mM in DMSO
  • 293754-55-9
  • C17H12NSO3F9
  • C17H12F9NO3S
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • PPAR and RXR Regulators
  • Gene Regulation and Expression
  • PPAR and RXR Regulators
  • Cell Signaling and Neuroscience
  • Gene Regulation and Expression
  • Inhibitors