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TYLOXAPOL

Product Name
TYLOXAPOL
CAS No.
25301-02-4
Chemical Name
TYLOXAPOL
Synonyms
alevaire;YLOXAPOL;TYLOXAPOL;tyloxypal;NSC-90255;superinone;superiuone;tritona-20;macrocyclon;tritonwr1339
CBNumber
CB0388643
Molecular Formula
C17H28O3
Formula Weight
280.41
MOL File
25301-02-4.mol
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TYLOXAPOL Property

Density 
1.1
Flash point:
113 °C
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Viscous Liquid
color 
Clear to hazy yellow to amber
Merck 
13,9901
InChI
InChI=1S/C14H22O.C2H4O.CH2O/c1-13(2,3)10-14(4,5)11-6-8-12(15)9-7-11;1-2-3-1;1-2/h6-9,15H,10H2,1-5H3;1-2H2;1H2
InChIKey
MDYZKJNTKZIUSK-UHFFFAOYSA-N
SMILES
C=O.C1OC1.C(C1C=CC(O)=CC=1)(C)(C)CC(C)(C)C
LogP
4.930 (est)
CAS DataBase Reference
25301-02-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
SM9750000
HS Code 
29222990
Toxicity
mouse,LD50,intraperitoneal,> 5gm/kg (5000mg/kg),Drugs in Japan Vol. 6, Pg. 467, 1982.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T0307
Product name
Tyloxapol
Purity
BioXtra
Packaging
5g
Price
$68.8
Updated
2024/03/01
Sigma-Aldrich
Product number
T0307
Product name
Tyloxapol
Purity
BioXtra
Packaging
10g
Price
$104
Updated
2024/03/01
Sigma-Aldrich
Product number
T8761
Product name
Tyloxapol
Purity
nonionic surfactant
Packaging
50g
Price
$262
Updated
2024/03/01
Sigma-Aldrich
Product number
T0307
Product name
Tyloxapol
Purity
BioXtra
Packaging
50g
Price
$365
Updated
2024/03/01
Sigma-Aldrich
Product number
1704003
Product name
Tyloxapol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
3x200mg
Price
$460
Updated
2024/03/01
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TYLOXAPOL Chemical Properties,Usage,Production

Description

Tyloxapol is a non-ionic liquid polymer of the alkylaryl polyether alcohol type. It has a wide range of uses as a surfactant (primarily for bronchopulmonary studies and drug delivery systems), an animal model inducer (used for induction of hyperlipidaemia in animals), and a reagent for biological studies (including studies of its mechanism of protection of macrophages against endotoxins and potential cytotoxicity).

Chemical Properties

clear to hazy yellow to amber viscous liquid

Originator

Solacen

Uses

anthelmintic, hepatotoxic

Uses

Tyloxapol, is a nonionic liquid polymer of the alkyl aryl polyether alcohol type. It is used as a surfactant to aid liquefaction and removal of mucopurulent (containing mucus and pus) bronchopulmonary secretions. Tyloxapol also blocks plasma lipolytic activity.

Definition

ChEBI: Tyloxapol is a polymeric compound resulting from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde to give a chain in which 6-8 molecules are linked together by CH2 groups ortho to the phenolic hydroxy groups, which have then undergone reaction with oxirane to give polyoxyethyleneoxy moieties, Ar(OCH2CH2)xOH, where x = 8-10. A nonionic liquic polymer, it inhibits lipoprotein lipase and hence clearance of triglyceride from the plasma, so is used to induce hyperlipidaemia in test animals. Also used as a surfactant to aid liquefaction and removal of mucus- and pus-containing bronchopulmonary secretions. It has a role as an inhibitor, an excipient, a surfactant and an apoptosis inducer.

Manufacturing Process

Srep 1: Into a 3-necked flask equipped with thermometer, mechanical agitator, and reflux condenser was charged the following: 412 g of α,α,γ,γ- tetramethylbutylphenol, 162 g of a 37% aqueous solution of formaldehyde, and 27.6 g of water. The mixture was agitated and heated to a temperature of 90°C. At this point, 246 g of oxalic acid and 0.92 g of Twitchell's reagent dissolved in 10 g of water were added. While being agitated, the reaction mixture was refluxed for 6 hours. 200 g of water and 384 g of toluene were added, and refluxing was continued for an hour.
Agitation was stopped and the contents of the flask were removed to a separatory funnel. The aqueous and resinous layers were separated and the solvent was removed from the resinous layer by vacuum distillation. After the removal of the solvent, heating at a reduced pressure of 1.5 to 2.5 mm and at a temperature of 245° to 250°C was continued for 4 1/2 hours. The condensate then had a viscosity of 4.0 poises when measured as a 60% solution in toluene and, on cooling, solidified to a brittle mass.
Step 2: A mixture of 118 parts of the product of Step 1, having hydroxyl number of 260, 2 parts of solid NaH, and 100 parts of toluene was heated to 125° to 150°C in an autoclave. Ethylene oxide was added slowly over a period of 2 1/2 hours until 261 parts of ethylene oxide were absorbed. This corresponds to 11 mols of ethylene oxide per mol of phenol in the product of Step 1. The toluene was then removed by steam distillation and the water by vacuum distillation at 10°C. The product was obtained as a viscous paste having a corrected hydroxyl number of 97. It was readily soluble in water and had marked detergent properties.

brand name

Superinone (Sterling Winthrop).

Therapeutic Function

Bronchodilator

General Description

Tyloxapol is a biocompatible surfactant

Mechanism of action

Tyloxapol, when injected IP, blocks plasma lipolytic activity, and thus the breakdown of triglyceride-rich lipoproteins. It has also been shown to be inhibitor of lipoprotein lipase, thus preventing triglyceride uptake.

TYLOXAPOL Preparation Products And Raw materials

Raw materials

Preparation Products

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TYLOXAPOL Suppliers

CHEMICAL LAND21
Tel
--
Fax
--
Email
sales21@chemicalland21.com
Country
South Korea
ProdList
6303
Advantage
74
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View Lastest Price from TYLOXAPOL manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
TYLOXAPOL 25301-02-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-20
Biopole Pharmatech Co., Ltd.
Product
Tyloxapol 25301-02-4
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100 ton
Release date
2024-01-19
Wuhan Monad Medicine Tech Co.,LTD
Product
Tyloxapol 25301-02-4
Price
US $50.00/KG
Min. Order
1Kg/Bag
Purity
99.99%
Supply Ability
20 tons/month
Release date
2021-04-19

25301-02-4, TYLOXAPOLRelated Search:


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  • 4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL POLYMER WITH FORMALDEHYDE AND OXIRANE
  • TYLOXAPOL
  • TRITON(R) WR-1339
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  • Tyloxapol 5GR
  • Tyloxapol, USP
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  • formaldehyde,oxirane,4-(2,4,4-trimethylpentan-2-yl)phenol
  • TYLOXAPOL ISO 9001:2015 REACH
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  • Tyloxapol (1704003)
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