ChemicalBook > CAS DataBase List > 4,5-Imidazoledicarboxylic acid

4,5-Imidazoledicarboxylic acid

Product Name: 4,5-Imidazoledicarboxylic acid
CAS No.: 570-22-9
Chemical Name: 4,5-Imidazoledicarboxylic acid
Synonyms: edicarboxyL;AKOS AUF2071;4,5-ImidazoL;AKOS BBS-00002898;IFLAB-BB F1918-0019;RARECHEM AL BO 1102;4,5-Dicarboxymidazole;4,5-Dicarboxyimidazole;4,5-Imidazoledicarboxylate;4,5-iMidazole dicarboxylic
CBNumber: CB0401861
Molecular Formula: C5H4N2O4
Formula Weight: 156.1
MOL File: 570-22-9.mol

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4,5-Imidazoledicarboxylic acid Property

Melting point:: 280-285 °C (dec.) (lit.)
Boiling point:: 280.29°C (rough estimate)
bulk density: 650-660kg/m3
Density: 1,749 g/cm³
refractive index: 1.4800 (estimate)
storage temp.: Store below +30°C.
solubility: 0.5g/l
pka: 3.59±0.10(Predicted)
form: Fine Crystalline Powder
color: Light yellow to yellow-brown
PH: 3.7 (0.5g/l, H2O, 20℃)
Water Solubility: 0.5g/L(20 ºC)
BRN: 147774
InChIKey: ZEVWQFWTGHFIDH-UHFFFAOYSA-N
CAS DataBase Reference: 570-22-9(CAS DataBase Reference)
NIST Chemistry Reference: 4,5-Imidazole dicarboxylic acid(570-22-9)
EPA Substance Registry System: 1H-Imidazole-4,5-dicarboxylic acid (570-22-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: NI4760000
Autoignition Temperature: 430°C
TSCA: Yes
HS Code: 29332990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 246115
Product name: 4,5-Imidazoledicarboxylic acid
Purity: 97%
Packaging: 5g
Price: $66.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 246115
Product name: 4,5-Imidazoledicarboxylic acid
Purity: 97%
Packaging: 25g
Price: $176
Updated: 2022/05/15

TCI Chemical

Product number: I0003
Product name: 1H-Imidazole-4,5-dicarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: I0003
Product name: 1H-Imidazole-4,5-dicarboxylic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $102
Updated: 2021/12/16

TRC

Product number: I387515
Product name: 4,5-Imidazoledicarboxylic acid
Packaging: 50g
Price: $250
Updated: 2021/12/16

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4,5-Imidazoledicarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

light yellow to yellow-brown fine cryst. powder

Uses

4,5-Imidazoledicarboxylic Acid is an intermediate used in the synthesis of N-substituted cyclic imides with anticancer and anti-inflammatory activities. it is also used to prepare imidazolecarboxamide derivatives with cannabinoid CB2 receptor antagonistic activities.

Uses

4,5-Imidazoledicarboxylic acid is an imidazole used for research purposes.

Synthesis

5465-29-2

570-22-9

General procedure: 800 ml of concentrated sulfuric acid (80% concentration) was slowly added to 200 ml of water to form a reaction system. To this system was added 50.0 g of 2-propylbenzimidazole, followed by the slow dropwise addition of 30 mL of hydrogen peroxide to 500 mL of the reaction mixture. The reaction is exothermic and causes reflux, and the rate of titration needs to be controlled to maintain the reaction solution at a boil. After completion of the reaction, stirring was continued for 3 hours. Subsequently, 1000 mL of water was added to the reaction mixture and cooled to room temperature. The mixture was stirred for 3 hours at 0 to 5°C to promote precipitation of solids. The solid was collected by filtration and washed sequentially with water and 5% aqueous sodium sulfite solution (100 mL). The resulting solid was purified by column chromatography using water: methanol = 2:1 as eluent to give the final imidazole-4,5-dicarboxylic acid 3-lg with a melting point of 267.3 °C (simultaneous decomposition).

References

[1] Patent: CN104262260, 2016, B. Location in patent: Paragraph 0093-0095

4,5-Imidazoledicarboxylic acid Preparation Products And Raw materials

Raw materials

Benzimidazole Hydrogen peroxide Triethyl orthoformate Anisole Benzimidazole Diaminomaleonitrile o-Phenylenediamine

Preparation Products

1H-Imidazole-4-carboxylic acid 1H-Imidazole-4-carbaldehyde Imidazole

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View Lastest Price from 4,5-Imidazoledicarboxylic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4,5-Imidazoledicarboxylic acid 570-22-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4,5-Imidazoledicarboxylic acid 570-22-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4,5-Imidazoledicarboxylic acid 570-22-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

570-22-9, 4,5-Imidazoledicarboxylic acidRelated Search:

Levamisole 2,5-PYRIDINEDICARBOXYLIC ACID Imidocarb dipropionate OXALIC ACID Imidazole 1,1'-Carbonyldiimidazole IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLIC ACID Imidazo[1,5-a]pyridine-6-carboxylic acid (9CI) 1H-Imidazole-2-carboxylic acid IMIDAZO[1,5-A]PYRIDINE-3-CARBALDEHYDE Ethyl Imidazo[1,2-a]pyridine-3-carboxylate METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE 3,5-DIMETHANOLPYRIDINE ETHYL IMIDAZOLE-2-CARBOXYLATE Methyl 4-imidazolecarboxylate Imidazole-2-carboxaldehyde 1H-Imidazol-2-carboxamide (1H-IMIDAZOL-2-YL)-METHANOL

4,5-IMIDAZOLEDICARBOXYLIC ACID

IMIDAZOLE-4,5-DICARBOXYLIC ACID

IFLAB-BB F1918-0019

AKOS BBS-00002898

AKOS AUF2071

alpha,beta-Imidazoledicarboxylic acid

alpha-beta-imidazolecarboxylicacid

Glycoxalinedicarboxylic acid

glycoxalinedicarboxylicacid

Glyoxalinedicarboxylic acid

H-Imidazole-4,5-dicarboxylicacid

RARECHEM AL BO 1102

,-Imidazoledicarboxylicacid

4,5-Dicarboxyimidazole

4,5-Imidazoledicarboxylate

1H-IMIDAZOLE-4,5-DICARBOXYLIC ACID

4,5-Imidazoledicarboxylic acid, 99℉

4,5-Imidazoledicarboxylicacid,97%

1H-Imidazole-4,5-dicarboxylic

4,5-Imidazoledicarboxylic acid, HPLC 99%

4,5-Dicarboxymidazole

4,5-Imidazoledicarboxylic acid,99%

Imidazole-4.5-dicarboxylic acid 5g [570-22-9]

4,5-iMidazole dicarboxylic

5-IMidazoledicarboxylic acid

4,5-IMidazoledicarboxylic acid, 99% 25GR

4,5-Dicarboxy-1H-imidazole

IMIDAZOLE-4,5-DICARBOXYLIC ACID FOR SYNT

4,5-Imidazoledicarboxylic acid 97%

IMidazo -4,5- twocarboxylic acid

Imidazole-4,5-dicarboxylic acid for synthesis

4,5-ImidazoL

edicarboxyL

1H-Imidazole-4,5-dicarboxylicAcid&gt

Imidazole-4,5-dicarboxylic acid (6CI, 8CI)

570-22-9

C65H4N2O4

Imidazoles

Heterocyclic Building Blocks

Building Blocks

Alcohols

Monomers

Polymer Science

Building Blocks

Heterocyclic Building Blocks

Imidazoles

Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines

Imidazol&Benzimidazole

Heterocyclic Compounds

Imidaxoles