ChemicalBook > CAS DataBase List > 2-Chloro-4-bromopyridine

2-Chloro-4-bromopyridine

Product Name
2-Chloro-4-bromopyridine
CAS No.
73583-37-6
Chemical Name
2-Chloro-4-bromopyridine
Synonyms
2-CHLORO-4-F;2-chloro-4-bromopyridne;2-Bromo-2-chloropyridine;2-CHLORO-4-BROMOPYRIDINE;2-CHLORO-4-FLUOROYRIDINE;4-BROMO-2-CHLOROPYRIDINE;2-Chloro-4-boroMopyridine;PYRIDINE, 4-BROMO-2-CHLORO-;4-Bromo-2-chloropyridine 98%;4-Bromo-2-chloropyridine >
CBNumber
CB0425188
Molecular Formula
C5H3BrClN
Formula Weight
192.44
MOL File
73583-37-6.mol
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2-Chloro-4-bromopyridine Property

Melting point:
27 C
Boiling point:
70 °C / 3mmHg
Density 
1.7336 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5900(lit.)
Flash point:
225 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.24±0.10(Predicted)
form 
Powder
Specific Gravity
1.7336
color 
Yellow
Water Solubility 
Not miscible or difficult to mix in water.
InChI
InChI=1S/C5H3BrClN/c6-4-1-2-8-5(7)3-4/h1-3H
InChIKey
ONHMWUXYIFULDO-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC(Br)=C1
CAS DataBase Reference
73583-37-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41-36/37/38
Safety Statements 
26-36-36/37/39-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
646318
Product name
4-Bromo-2-chloropyridine
Purity
97%
Packaging
5g
Price
$41.4
Updated
2022/05/15
Sigma-Aldrich
Product number
646318
Product name
4-Bromo-2-chloropyridine
Purity
97%
Packaging
25g
Price
$136
Updated
2022/05/15
TCI Chemical
Product number
B2951
Product name
4-Bromo-2-chloropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
B2951
Product name
4-Bromo-2-chloropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$43
Updated
2025/07/31
TRC
Product number
B682210
Product name
4-Bromo-2-chloro-pyridine
Packaging
5g
Price
$100
Updated
2021/12/16
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2-Chloro-4-bromopyridine Chemical Properties,Usage,Production

Chemical Properties

Off-white Cryst

Uses

It is used in the synthesis of quaterpyridine nemertelline.

Synthesis

14432-12-3

73583-37-6

Step a: Synthesis of 2-chloro-4-bromopyridine To 8.9 g (69.2 mmol) of 2-chloro-4-aminopyridine was added 81.5 mL of 48% aqueous hydrobromic acid at 0 °C. Subsequently, 33.4 g (208.75 mmol) of bromine monomer was slowly added over 10 min. The reaction mixture was cooled to -10°C and 10.65 g (154 mmol) of sodium nitrite dissolved in 20 mL of water was added dropwise over 30 min. After the dropwise addition was completed, stirring was continued at -10°C for 10 minutes and then brought to room temperature and stirred for 1.5 hours. Upon completion of the reaction, the mixture was cooled to 5°C and saturated aqueous sodium sulfite solution was added until the reaction solution was colorless. The reaction solution was adjusted to alkaline with 35% sodium hydroxide aqueous solution. The basic aqueous phase was extracted twice with diethyl ether, the organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated. The yellow oil obtained (13 g) was purified by silica gel column chromatography (eluent: ethyl acetate/heptane=1/9). The product was a light-colored oily substance in 52% yield. 1H NMR (CDCl3): δ 8.25 (d, 1H, J = 5Hz), 7.55 (s, 1H), 7.4 (d, 1H, J = 5Hz).

References

[1] Journal of Organic Chemistry, 2006, vol. 71, # 22, p. 8602 - 8609
[2] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[3] Patent: US2006/89364, 2006, A1. Location in patent: Page/Page column 22
[4] Roczniki Chemii, 1955, vol. 29, p. 1019,1025
[5] Chem.Abstr., 1956, p. 12045

2-Chloro-4-bromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-4-bromopyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-4-bromopyridine 73583-37-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-30
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Chloro-4-bromopyridine 73583-37-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-4-bromopyridine 73583-37-6
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-31

73583-37-6, 2-Chloro-4-bromopyridineRelated Search:

2-CHLORO-3-BROMOPYRIDINE 2-Fluoro-3-Chloro-5-Bromopyridine 2-Chloro-4-bromopyridine 3-Bromo-2-methoxy-5-trifluoromethylpyridine 4-BROMO-2-CHLORO-5-FLUOROPYRIDINE 4-Bromo-2-chloro-3-iodopyridine 4-CHLORO-3-BROMOPYRIDINE 3-BROMO-2,5-DICHLOROPYRIDINE 5-Bromo-6-chloropyridine-3-sulfonyl chloride 5-BROMO-3-CHLORO-2-HYDROXYPYRIDINE 5-Bromo-2,3-dichloropyridine 5-Bromo-2-chloropyridine 2-Chloro-5-Bromopyridine,2-CHLORO-5-BROMOPYRIDINE 5-BROMO-2-CHLORO-PYRIDINE,2-CHLORO-5-BROMOPYRIDINE 2-Pyridinamine, 5-bromo-4-chloro- Pyridine, 4-bromo-2,5-dichloro- 3-Bromo-2,6-dichloropyridine 2-AMINO-5-CHLORO-3-BROMOPYRIDINE Pyridine, 2-fluloro-4-chloro-5-bromo- 5-BROMO-3-CHLORO-2-METHYLPYRIDINE

  • 2-Chloro-4-boroMopyridine
  • 2 - chloro - 4 - broMide pyridine
  • PYRIDINE, 4-BROMO-2-CHLORO-
  • 2-CHLORO-4-F
  • 4-BROMO-2-CHLOROPYRIDINE
  • 4-Bromo-2-chloropyridine 98%
  • 2-chloro-4-bromopyridne
  • 2-CHLORO-4-FLUOROYRIDINE
  • 2-CHLORO-4-BROMOPYRIDINE
  • 4-Bromo-2-chloropyridine ,98%
  • 2-Bromo-2-chloropyridine
  • 4-Bromo-2-chloropyridine &gt
  • 3-Amino-5-bromo-3-chloropyridine
  • 2-Chloro-4-bromopyridine ISO 9001：2015 REACH
  • 73583-37-6
  • 75583-37-6
  • 73583-80-2
  • 3583-37-6
  • C6H3NBrCl
  • Building Blocks
  • Pyridines
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Variety of halogenated heterocyclic series
  • Bromopyridines
  • Chloropyridines
  • Halopyridines
  • Boronic Acid
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines, Pyrimidines, Purines and Pteredines
  • pharmacetical
  • Pyridine series
  • Halides
  • blocks
  • Bromides
  • Pyridines
  • Pyridine