ACA

Product Name: ACA
CAS No.: 110683-10-8
Chemical Name: ACA
Synonyms: ACA;4-amylcinnamoylanthranilicacid;N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID;N-(p-Amylcinnamoyl) anthranilic Acid (ACA);2-(3-(4-Pentylphenyl)acrylamido)benzoic acid;2-[3-(4-pentylphenyl)prop-2-enamido]benzoic acid;N-(p-amylcinnamoyl) Anthranilic Acid, 10 mM in DMSO;2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID;Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-;N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor
CBNumber: CB0489432
Molecular Formula: C21H23NO3
Formula Weight: 337.41
MOL File: 110683-10-8.mol

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ACA Property

Melting point:: 172-174℃
Boiling point:: 563.1±50.0 °C(Predicted)
Density: 1.178±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly)
pka: 3.49±0.36(Predicted)
form: White solid.
color: White to Off-White

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Safety

HazardClass: 9

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H410Very toxic to aquatic life with long lasting effects
Precautionary statements: P403Store in a well-ventilated place.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67339
Product name: N-(4-n-Pentylcinnamoyl)anthranilic acid
Packaging: 50mg
Price: $151
Updated: 2023/06/20

Cayman Chemical

Product number: 14531
Product name: N-(p-amylcinnamoyl) Anthranilic Acid
Purity: ≥95%
Packaging: 25mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14531
Product name: N-(p-amylcinnamoyl) Anthranilic Acid
Purity: ≥95%
Packaging: 50mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 14531
Product name: N-(p-amylcinnamoyl) Anthranilic Acid
Purity: ≥95%
Packaging: 100mg
Price: $168
Updated: 2024/03/01

Cayman Chemical

Product number: 14531
Product name: N-(p-amylcinnamoyl) Anthranilic Acid
Purity: ≥95%
Packaging: 250mg
Price: $330
Updated: 2024/03/01

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ACA Chemical Properties,Usage,Production

Uses

N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.

Definition

ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide.

Biological Activity

Cell permeable: yes', 'Primary Target
A2PLA2', 'Product does not compete with ATP.', 'Reversible: no

References

harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6.

ACA Preparation Products And Raw materials

Raw materials

Preparation Products

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ACA Suppliers

China 48 India 1 Japan 1 United Kingdom 1 United States 12 Global 63

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

United States Biological

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Country: United States
ProdList: 6075
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ApexBio Technology

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Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Cayman Chemical Company

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Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

MedChemExpress

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EMD Biosciences, Inc.

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Email: technical@calbiochem.com
Country: United States
ProdList: 6529
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MP Biomedicals, Inc.

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Country: United States
ProdList: 6561
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BIOMOL INTERNATIONAL, LP

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Email: info@biomol.com
Country: United States
ProdList: 1499
Advantage: 77

110683-10-8, ACARelated Search:

Inositol alpha-Amylcinnamaldehyde H-6-Aca-OH~epsilon-Aminocaproic acid~6-Aminohexanoic acid~EACA,h-6-aca-oh Boc-6-AMinocaproic acid 7-TMCA Hydroxymethyl-7-ACA N-Benzyloxycarbonyl-6-aminohexanoic acid 7-ACA-3-MTT-7-MO,7-ACA-3-MTT-7-MO / 7-MAC ACA 7-ACA 7-Aca-3-SmtC10H12N6O6S3,7-aca-3-smt FMOC-6-ACA-OH ECPP-ACA Glutaryl-7-ACA acylase ACA 2-(P-AMYLCINNAMOYL)AMINO-4-CHLOROBENZOIC ACID ACA AKOS BBS-00007306

2-(3-(4-Pentylphenyl)acrylamido)benzoic acid

N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID

4-amylcinnamoylanthranilicacid

2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID

N-(p-Amylcinnamoyl) anthranilic Acid (ACA)

ACA

Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-

N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor

2-[3-(4-pentylphenyl)prop-2-enamido]benzoic acid

N-(p-amylcinnamoyl) Anthranilic Acid, 10 mM in DMSO

110683-10-8