ChemicalBook > CAS DataBase List > 2-Hydroxy-4-(trifluoromethyl)quinoline

2-Hydroxy-4-(trifluoromethyl)quinoline

Product Name
2-Hydroxy-4-(trifluoromethyl)quinoline
CAS No.
25199-84-2
Chemical Name
2-Hydroxy-4-(trifluoromethyl)quinoline
Synonyms
BUTTPARK 33\04-80;4-(Trifluoromethyl)quinolin-2-ol;4-Trifluoromethyl-1H-quinolin-2-one;4-trifluoroMethyl-2(1H)-quinolinone;4-(trifluoromethyl)quinolin-2(1H)-one;2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE;4--(TrifluoroMethyl)quinoline-2(H)-one;2-hydroxy-4-(trifluoroMethyl)quinqline;4-Trifluoromethyl-2(1H)-quinolinone,97%;2(1H)-Quinolinone, 4-(trifluoromethyl)-
CBNumber
CB0496696
Molecular Formula
C10H6F3NO
Formula Weight
213.16
MOL File
25199-84-2.mol
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2-Hydroxy-4-(trifluoromethyl)quinoline Property

Melting point:
>240°C
Boiling point:
284 ºC
Density 
1.391
Flash point:
126 ºC
storage temp. 
Sealed in dry,Room Temperature
form 
Solid
color 
White
InChI
InChI=1S/C10H6F3NO/c11-10(12,13)7-5-9(15)14-8-4-2-1-3-6(7)8/h1-5H,(H,14,15)
InChIKey
UUROBWTVZZNDFD-UHFFFAOYSA-N
SMILES
N1C2=C(C=CC=C2)C(C(F)(F)F)=CC1=O
CAS DataBase Reference
25199-84-2
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Safety

Safety Statements 
24/25
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
H61732
Product name
4-Trifluoromethyl-2(1H)-quinolinone, 97%
Packaging
1g
Price
$264
Updated
2024/03/01
Alfa Aesar
Product number
H61732
Product name
4-Trifluoromethyl-2(1H)-quinolinone, 97%
Packaging
250mg
Price
$92.2
Updated
2023/06/20
TRC
Product number
T900055
Product name
4-(trifluoromethyl)quinolin-2(1H)-one
Packaging
50mg
Price
$90
Updated
2021/12/16
Matrix Scientific
Product number
074152
Product name
2-Hydroxy-4-(trifluoromethyl)quinoline
Purity
95+%
Packaging
1g
Price
$416
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
37718
Product name
2-Hydroxy-4-(trifluoromethyl)quinoline
Purity
95+%
Packaging
1g
Price
$447
Updated
2021/12/16
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2-Hydroxy-4-(trifluoromethyl)quinoline Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

4-Trifluoromethylquinolin-2(1H)-one was prepared by reacting aniline and ethyl-4,4,4-trifluoroacetoacetate stirred in toluene.
Experimental Procedure: In a 1 L round flask fitted with a reflux condenser a mixture of 25.60 g aniline, 50.0 g ethyl-4,4,4-trifluoroacetoacetate 300 ml toluene was heated to reflux in an oil bath at 130 °C. After 20 min 3 ml water was added and the mixture was heated at reflux for another 24 h. the reaction mixture was cooled to room temperature and concentrated under reduced pressure. A round flask with 200 mL H2SO4 was heated to 80°C and the crude oil from the step before was added in portions to the H2SO4 keeping the internal temperature below 90°C, total addition time was approximately 40 min. After addition was complete, the mixture was stirred at 80°C for 1 h, cooled and poured onto 400 g crushed ice. The resulting solids were filtered, washed with water, and dried under vacuum at 40°C to give 33.0 g (50%) product (2-Hydroxy-4-(trifluoromethyl)quinoline) as a colorless solid.

2-Hydroxy-4-(trifluoromethyl)quinoline Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate 4-Fluoroaniline Sulfuric acid

Preparation Products

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View Lastest Price from 2-Hydroxy-4-(trifluoromethyl)quinoline manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE 25199-84-2
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-29
Career Henan Chemical Co
Product
2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE 25199-84-2
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

25199-84-2, 2-Hydroxy-4-(trifluoromethyl)quinolineRelated Search:

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  • BUTTPARK 33\04-80
  • 2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE
  • 4-(Trifluoromethyl)quinolin-2-ol
  • 4-Trifluoromethyl-1H-quinolin-2-one
  • 2-Hydroxy-4-(trifluoromethyl)quinoline ,98%
  • 4-(trifluoromethyl)quinolin-2(1H)-one
  • 2-hydroxy-4-(trifluoroMethyl)quinqline
  • 4--(TrifluoroMethyl)quinoline-2(H)-one
  • 4-trifluoroMethyl-2(1H)-quinolinone
  • 2(1H)-Quinolinone, 4-(trifluoromethyl)-
  • 4-Trifluoromethyl-2(1H)-quinolinone,97%
  • 2-HYDROXY-4-(TRIFLUOROMETHYL)QUINOLINE ISO 9001：2015 REACH
  • 25199-84-2
  • C10H6F3NO