CHOLERA TOXIN

Product Name: CHOLERA TOXIN
CAS No.: 9012-63-9
Chemical Name: CHOLERA TOXIN
Synonyms: Cholergen;choleragen;CHOLERA TOXIN;Choleragenoid;choleraexotoxin;exo-enterotoxin;Toxins, cholera;CHOLERA ENTEROTOXIN;VIBRIO CHOLERAE TOXIN;choleraentero-exotoxin
CBNumber: CB0683337
Molecular Formula: NULL
Formula Weight: 0
MOL File: Mol file

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CHOLERA TOXIN Property

storage temp.: 0-6°C
solubility: H2O: soluble10mg/mL
form: lyophilized powder
color: White to off-white

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Safety

Hazard Codes: T
Risk Statements: 24/25-52/53
Safety Statements: 36/37-45-61
RIDADR: 3172
WGK Germany: 2
RTECS: LF3100000
HazardClass: 6.1
PackingGroup: I
Toxicity: cholera toxin is secreted by the gram-negative bacterium Vibrio cholerae. It is a gastrointestinal toxin that increases adenylate cyclase activity of mucosa of the small intestine, thereby increasing cyclic AMP within these cells. Cyclic AMP stimulates active transport of ions by these epithelial cells, resulting in a large efflux of Na+ and water into the gut. The toxin enters cells by interacting with a GM1 ganglioside on the cell surface. After entry, the A1 subunit catalyzes the transfer of an ADP-ribose unit from NAD+ to an arginine side chain of the adenylate cyclase regulatory G protein, blocking its GTPase activity. Thus the adenylate cyclase deactivation mechanism is destroyed, and cyclic AMP is continually produced. The major sign of cholera poisoning is severe diarrhea; several liters of body water may be lost within a few hours, leading to shock and death if fluid is not replaced. Treatment involves physiological support (including i.v. fluids) and antibiotics.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H332Harmful if inhaled

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C8052
Product name: Cholera Toxin from Vibrio cholerae
Purity: ≥90% (SDS-PAGE), lyophilized powder
Packaging: 0.5mg
Price: $171
Updated: 2024/03/01

Sigma-Aldrich

Product number: C8052
Product name: Cholera Toxin from Vibrio cholerae
Purity: ~95% (SDS-PAGE)
Packaging: 1mg
Price: $296
Updated: 2024/03/01

Sigma-Aldrich

Product number: 227036
Product name: CholeraToxin,Vibriocholerae,TypeInaba569B,AzideFree-CAS9012-63-9-Calbiochem
Purity: CholeratoxinInaba569B,CAS9012-63-9,hasasingleAsubunitsurroundedbyfi
Packaging: 1mg
Price: $297
Updated: 2024/03/01

Cayman Chemical

Product number: 23217
Product name: Cholera Toxin from Vibrio cholerae
Purity: ≥95% (estimated by SDS-PAGE)
Packaging: 1mg
Price: $188
Updated: 2021/12/16

Cayman Chemical

Product number: 23217
Product name: Cholera Toxin from Vibrio cholerae
Purity: ≥95% (estimated by SDS-PAGE)
Packaging: 2mg
Price: $357
Updated: 2021/12/16

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CHOLERA TOXIN Chemical Properties,Usage,Production

Uses

Cholera Toxin from Vibrio cholerae has been used as a positive control in cAMP (cyclic AMP) assay for enterotoxins. It has been added as a supplement in cell culture media of primary tumors and epithelial cells.

Biochem/physiol Actions

Toxin consisting of an A subunit (27 kDa) surrounded by five B subunits (approximately 12 kDa each), which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.

CHOLERA TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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CHOLERA TOXIN Suppliers

China 31 France 1 Germany 1 Japan 1 Switzerland 1 United Kingdom 2 United States 10 Global 47

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9012-63-9, CHOLERA TOXINRelated Search:

Tosylmethyl isocyanide Aluminum acetylacetonate METHYL ISOCYANOACETATE SALCOMINE Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) PHENYLSELENOL 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE 2,4-PENTANEDIONE, SILVER DERIVATIVE TERT-BUTYL ISOCYANIDE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) N-BUTYLISOCYANIDE Ferric acetylacetonate Cupric acetylacetonate Ethyl isocyanoacetate COBALT(II) ACETYLACETONATE Tris(2,4-pentanedionato)chroMiuM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

Choleragenoid

Cholera Toxin from Vibrio cholerae,Cholera enterotoxin, Cholergen

Cholergen

CHOLERA TOXIN

CHOLERA ENTEROTOXIN

CHOLERA TOXIN, VIBRIO CHOLERAE, TYPE INABA 569B

VIBRIO CHOLERAE TOXIN

choleraentero-exotoxin

choleraexotoxin

choleragen

exo-enterotoxin

exotoxin,vibriocholerae

CHOLERA TOXIN FROM VIBRIO CHOLERAE

Toxins, cholera

9012-63-9

G Protein Function

G Proteins and Cyclic Nucleotides

Reagents

BioChemical

Cell Signaling and Neuroscience

Cell Biology