ChemicalBook > CAS DataBase List > 5-AMINO-2-BROMOBENZOIC ACID

5-AMINO-2-BROMOBENZOIC ACID

Product Name: 5-AMINO-2-BROMOBENZOIC ACID
CAS No.: 2840-02-0
Chemical Name: 5-AMINO-2-BROMOBENZOIC ACID
Synonyms: 5-AMINO-2-BROMOBENZOIC;4-Bromo-3-carboxyaniline;2-Bromo-5-aminobenzoic acid;5-AMINO-2-BROMOBENZOIC ACID;Benzoic acid, 5-amino-2-bromo-;5-Amino-2-bromobenzoic acid 94%;5-AMINO-2-BROMOBENZOIC ACID USP/EP/BP
CBNumber: CB0707330
Molecular Formula: C7H6BrNO2
Formula Weight: 216.03
MOL File: 2840-02-0.mol

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5-AMINO-2-BROMOBENZOIC ACID Property

Melting point:: 171-179 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Brown
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C7H6BrNO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,9H2,(H,10,11)
InChIKey: FEXDUVBQBNYSQV-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC(N)=CC=C1Br
CAS DataBase Reference: 2840-02-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 668036
Product name: 5-Amino-2-bromobenzoic acid
Purity: 94%
Packaging: 5g
Price: $84.3
Updated: 2023/06/20

Sigma-Aldrich

Product number: 668036
Product name: 5-Amino-2-bromobenzoic acid
Purity: 94%
Packaging: 25g
Price: $359
Updated: 2023/06/20

TRC

Product number: A602490
Product name: 5-Amino-2-bromobenzoic acid
Packaging: 10g
Price: $80
Updated: 2021/12/16

Apolloscientific

Product number: OR4307
Product name: 5-Amino-2-bromobenzoic acid
Packaging: 1g
Price: $15
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4657-9-X1
Product name: 5-Amino-2-bromobenzoic acid
Packaging: 1g
Price: $16
Updated: 2021/12/16

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5-AMINO-2-BROMOBENZOIC ACID Chemical Properties,Usage,Production

Chemical Properties

White crystalline solid

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs and is also used in medicine.

Uses

5-Amino-2-bromobenzoic Acid can be used for FABP4 and FABP4 inhibitors to prevent or treat FABP 4/5 related diseases.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

99-05-8

2840-02-0

General procedure for the synthesis of 5-amino-2-bromobenzoic acid from 3-aminobenzoic acid: 3-aminobenzoic acid (3.00 g, 21.9 mmol) was dissolved in N,N-dimethylformamide (18.0 mL) and cooled to below 5 °C. In another vessel, a solution was prepared by mixing N,N-dimethylformamide (9.00 mL) with N-bromosuccinimide (4.09 g, 23.0 mmol). This solution was slowly added to the cooled 3-aminobenzoic acid solution, keeping the reaction temperature at 5 °C or lower. The reaction mixture was stirred at 5 °C for 1 h. After the reaction mixture was stirred for 1 h, water (60.0 mL) was added and the stirring was continued for 12 h at 5 °C. Upon completion of the reaction, the solid product was collected by filtration, and the filtrate was washed with water (5.00 mL) and dried to give 5-amino-2-bromobenzoic acid (3.68 g, 78% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-D6): δ 5.49 (s, 2H), 6.59 (dd, J = 8.5,2.9Hz, 1H), 6.93 (d, J = 2.9Hz, 1H), 7.25 (d, J = 8.5Hz, 1H), 13.04 (s, 1H).

Purification Methods

Crystallise the acid from H2O or *C6H6 (m 128o). The acetyl derivative crystallises from H2O (as monohydrate) or absolute EtOH with m 196-197o (anhydrous). [Koopal Rec Trav Chim, Pays Bas 34 148 1915, Bamberger Chem Ber 57 2090 1924, Beilstein 14 H 413, 14 II 245.]

References

[1] Patent: US2013/310576, 2013, A1. Location in patent: Paragraph 0151

5-AMINO-2-BROMOBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-AMINO-2-BROMOBENZOIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-AMINO-2-BROMOBENZOIC ACID 2840-02-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: 5-AMINO-2-BROMOBENZOIC ACID 2840-02-0
Price: US $30.00-7.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 5-AMINO-2-BROMOBENZOIC ACID 2840-02-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

2840-02-0, 5-AMINO-2-BROMOBENZOIC ACIDRelated Search:

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5-AMINO-2-BROMOBENZOIC ACID USP/EP/BP

2840-02-0

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts

Phenylacetic acid

Aromatic Amino AcidsCarbonyl Compounds

Carboxylic Acids

Peptide Synthesis

Unnatural Amino Acid Derivatives