5-AMINO-2-BROMOBENZOIC ACID
- Product Name
- 5-AMINO-2-BROMOBENZOIC ACID
- CAS No.
- 2840-02-0
- Chemical Name
- 5-AMINO-2-BROMOBENZOIC ACID
- Synonyms
- 5-AMINO-2-BROMOBENZOIC;4-Bromo-3-carboxyaniline;2-Bromo-5-aminobenzoic acid;5-AMINO-2-BROMOBENZOIC ACID;Benzoic acid, 5-amino-2-bromo-;5-Amino-2-bromobenzoic acid 94%;5-AMINO-2-BROMOBENZOIC ACID USP/EP/BP
- CBNumber
- CB0707330
- Molecular Formula
- C7H6BrNO2
- Formula Weight
- 216.03
- MOL File
- 2840-02-0.mol
5-AMINO-2-BROMOBENZOIC ACID Property
- Melting point:
- 171-179 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Brown
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H6BrNO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,9H2,(H,10,11)
- InChIKey
- FEXDUVBQBNYSQV-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(N)=CC=C1Br
- CAS DataBase Reference
- 2840-02-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- Hazard Note
- Harmful
- HazardClass
- 6.1
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 668036
- Product name
- 5-Amino-2-bromobenzoic acid
- Purity
- 94%
- Packaging
- 5g
- Price
- $84.3
- Updated
- 2023/06/20
- Product number
- 668036
- Product name
- 5-Amino-2-bromobenzoic acid
- Purity
- 94%
- Packaging
- 25g
- Price
- $359
- Updated
- 2023/06/20
- Product number
- A602490
- Product name
- 5-Amino-2-bromobenzoic acid
- Packaging
- 10g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FA70334
- Product name
- 5-Amino-2-bromobenzoic acid
- Packaging
- 50g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- OR4307
- Product name
- 5-Amino-2-bromobenzoic acid
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
5-AMINO-2-BROMOBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White crystalline solid
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs and is also used in medicine.
Uses
5-Amino-2-bromobenzoic Acid can be used for FABP4 and FABP4 inhibitors to prevent or treat FABP 4/5 related diseases.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
99-05-8
2840-02-0
General procedure for the synthesis of 5-amino-2-bromobenzoic acid from 3-aminobenzoic acid: 3-aminobenzoic acid (3.00 g, 21.9 mmol) was dissolved in N,N-dimethylformamide (18.0 mL) and cooled to below 5 °C. In another vessel, a solution was prepared by mixing N,N-dimethylformamide (9.00 mL) with N-bromosuccinimide (4.09 g, 23.0 mmol). This solution was slowly added to the cooled 3-aminobenzoic acid solution, keeping the reaction temperature at 5 °C or lower. The reaction mixture was stirred at 5 °C for 1 h. After the reaction mixture was stirred for 1 h, water (60.0 mL) was added and the stirring was continued for 12 h at 5 °C. Upon completion of the reaction, the solid product was collected by filtration, and the filtrate was washed with water (5.00 mL) and dried to give 5-amino-2-bromobenzoic acid (3.68 g, 78% yield). The structure of the product was confirmed by 1H-NMR (400 MHz, DMSO-D6): δ 5.49 (s, 2H), 6.59 (dd, J = 8.5,2.9Hz, 1H), 6.93 (d, J = 2.9Hz, 1H), 7.25 (d, J = 8.5Hz, 1H), 13.04 (s, 1H).
Purification Methods
Crystallise the acid from H2O or *C6H6 (m 128o). The acetyl derivative crystallises from H2O (as monohydrate) or absolute EtOH with m 196-197o (anhydrous). [Koopal Rec Trav Chim, Pays Bas 34 148 1915, Bamberger Chem Ber 57 2090 1924, Beilstein 14 H 413, 14 II 245.]
References
[1] Patent: US2013/310576, 2013, A1. Location in patent: Paragraph 0151
5-AMINO-2-BROMOBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
5-AMINO-2-BROMOBENZOIC ACID Suppliers
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- Country
- Switzerland
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View Lastest Price from 5-AMINO-2-BROMOBENZOIC ACID manufacturers
- Product
- 5-AMINO-2-BROMOBENZOIC ACID 2840-02-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- 5-AMINO-2-BROMOBENZOIC ACID 2840-02-0
- Price
- US $30.00-7.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-09-08
- Product
- 5-AMINO-2-BROMOBENZOIC ACID 2840-02-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11