1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE

Product Name: 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
CAS No.: 5317-33-9
Chemical Name: 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE
Synonyms: AKOS BC-0902;CHEMBRDG-BB 4013939;4-METHYL-1-PIPERAZINEPROPANOL;3-(N-METHYLPIPERAZINE)-PROPANOL;1-Piperazinepropanol, 4-methyl-;4-Methyl-1-piperazine-1-propanol;1-(3-Hydroxypropyl)-4-methyl-pipe;3-(N-METHYLPIPERAZINE)-PROPAN-1-OL;3-(4-methyl-1-piperazine)propan-1-ol;3-(4-Methylpiperazin-1-yl)-1-propanol
CBNumber: CB0727644
Molecular Formula: C8H18N2O
Formula Weight: 158.24
MOL File: 5317-33-9.mol

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1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Property

Melting point:: 30 °C
Boiling point:: 75-78°C/0.5mm
Density: 0.988±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly)
form: Solid
pka: 15.10±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C8H18N2O/c1-9-4-6-10(7-5-9)3-2-8-11/h11H,2-8H2,1H3
InChIKey: IIXZEUJZLXHPLB-UHFFFAOYSA-N
SMILES: N1(CCCO)CCN(C)CC1
CAS DataBase Reference: 5317-33-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 24/25-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M327365
Product name: 4-Methyl-1-piperazinepropanol
Packaging: 5g
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 116070
Product name: 3-(N-Methylpiperazine)-propanol
Purity: >90%
Packaging: 5g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 116070
Product name: 3-(N-Methylpiperazine)-propanol
Purity: >90%
Packaging: 10g
Price: $14
Updated: 2021/12/16

Apolloscientific

Product number: OR0881
Product name: 1-(3-Hydroxyprop-1-yl)-4-methylpiperazine
Purity: 95%
Packaging: 1g
Price: $28
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-XT
Product name: 1-(3-Hydroxypropyl)-4-methylpiperazine
Packaging: 1g
Price: $55
Updated: 2021/12/16

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1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Chemical Properties,Usage,Production

Uses

4-Methyl-1-piperazinepropanol is a useful synthetic organic compound used in the synthesis of S-Alkyl-N-alkylisothiourea compounds.

Synthesis

109-01-3

627-18-9

5317-33-9

General procedure for the synthesis of 1-(3-hydroxypropyl)-4-methylpiperazine from N-methylpiperazine and 3-bromo-1-propanol: Intermediate 7: 3-(4-methylpiperazin-1-yl)-propan-1-ol. Dissolve N-methylpiperazine (6.99 mL, 63 mmol) in toluene (30 mL). 3-Bromo-1-propanol (2.62 mL, 30 mmol) was added slowly and the reaction mixture was stirred at room temperature overnight. Subsequently, the reaction mixture was heated to 80 °C and kept for 2 h, and then cooled to room temperature. The reaction mixture was filtered and the filter cake was washed thoroughly with toluene. After removal of toluene under reduced pressure, the residue was subjected to Kugelrohr distillation (boiling point: 180 °C/2 mbar) to give a colorless oily product (4.08 g, 25.8 mmol, 86% yield). 1H NMR (CDCl3): δ= 1.70 (pseudo quintuple peak, J = 5.8 Hz, 2H), 2.26 (s, 3H), 2.35-2.60 (m, 8H), 2.60 (pseudo triple peak, J = 5.8 Hz, 2H), 3.77 (pseudo triple peak, J = 5.3 Hz, 2H), 4.09 (broad single peak, 1H).

References

[1] Patent: EP1674467, 2006, A1. Location in patent: Page/Page column 26
[2] Patent: EP1674466, 2006, A1. Location in patent: Page/Page column 27
[3] Patent: US2006/142570, 2006, A1. Location in patent: Page/Page column 17
[4] Patent: US2006/135782, 2006, A1. Location in patent: Page/Page column 26
[5] Patent: EP1746096, 2007, A1. Location in patent: Page/Page column 25

1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE Suppliers

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View Lastest Price from 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE 5317-33-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE 5317-33-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2019-12-19

5317-33-9, 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINERelated Search:

Dropropizine eprozinol 1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE 1-Piperazinepropanol Naftopidil dihydrochloride VERRUCULOGEN Doxazosin Centpropazine 1,4-BIS(2-CARBOXYETHYL)PIPERAZINE 1-[3-(3,4-METHYLENEDIOXYPHENOXY)PROPYL]-4-PHENYL-PIPERAZINE MALEATE 3-(4-methylpiperazin-1-yl)propanoic acid 1,4-BIS(2-HYDROXYPROPYL)-2-METHYLPIPERAZINE 3-HYDROXY-1-(IODOMETHYL)-3,8-DIMETHYL-8-AZA-5-AZONIASPIRO[4.5]DECANE IODIDE 1-METHYL-4-OXIRANYLMETHYL-PIPERAZINE 1-(BENZYLOXY)-3-(4-METHYLPIPERAZIN-1-YL)PROPAN-2-OL DIHYDROCHLORIDE ZERENEX ZX000053 1-(4-ETHYLPHENOXY)-3-(4-METHYLPIPERAZIN-1-YL)PROPAN-2-OL DIHYDROCHLORIDE SALOR-INT L120286-1EA

3-(4-METHYL-PIPERAZIN-1-YL)-PROPAN-1-OL

1-(3-HYDROXYPROPYL)-4-METHYLPIPERAZINE

N-METHYL-N'-(3 HYDROXYLPROPYL) PIPERAZINE

3-(4-methyl-1-piperazine)propan-1-ol

1-Piperazinepropanol,4-methyl-(6CI,7CI,8CI,9CI)

1-(3-HYDROXYPROPYL)-4-METHYL-PIPERAZINE >98%

3-(4-Methylpiperazin-1-yl)-1-propanol

4-Methyl-1-piperazine-1-propanol

3-(4-methyl-1-piperazinyl)propan-1-ol dihydrochloride

3-(4-Methylpiperazin-1-yl)propan-1-ol dihydrochloride

1-(2-hydroxypropyl)-4-methylpiperazine

CHEMBRDG-BB 4013939

AKOS BC-0902

3-(N-METHYLPIPERAZINE)-PROPAN-1-OL

3-(N-METHYLPIPERAZINE)-PROPANOL

4-METHYL-1-PIPERAZINEPROPANOL

1-(3-Hydroxyprop-1-yl)-4-methylpiperazine

1-Piperazinepropanol, 4-methyl-

1-(3-Hydroxypropyl)-4-methyl-pipe

5317-33-9

C8H18N2O

pharmacetical

piperazines

PIPERIDINE