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Triethylamine hydrochloride

Product Name
Triethylamine hydrochloride
CAS No.
554-68-7
Chemical Name
Triethylamine hydrochloride
Synonyms
TRIETHYLAMMONIUM CHLORIDE;TRIETHYLAMINE HCL;Et3·HCl;[E3N]HCl;Trimethylamine Hci;Triethylamine hydroc;Triethylammoniumchlorid;Tolzaoline bydrochloride;TriethylaminHydrochlorid;triethylammomium chloride
CBNumber
CB0767833
Molecular Formula
C6H16ClN
Formula Weight
137.65
MOL File
554-68-7.mol
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Triethylamine hydrochloride Property

Melting point:
261 °C (dec.)(lit.)
Boiling point:
223.18°C (rough estimate)
Density 
1.07
refractive index 
1.4530 (estimate)
storage temp. 
Store below +30°C.
solubility 
1440 g/L (20°C)
form 
Crystalline Powder
color 
White to off-white
PH
5 (10g/l, H2O, 20℃)
Water Solubility 
1440 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,9666
BRN 
3906409
InChIKey
ILWRPSCZWQJDMK-UHFFFAOYSA-N
CAS DataBase Reference
554-68-7(CAS DataBase Reference)
EPA Substance Registry System
Ethanamine, N,N-diethyl-, hydrochloride (554-68-7)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39-22
WGK Germany 
1
RTECS 
YE2111500
F 
3
TSCA 
Yes
HS Code 
29211910
Hazardous Substances Data
554-68-7(Hazardous Substances Data)
Toxicity
LDLo scu-mus: 600 mg/kg JPETAB 37,309,29
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
90350
Product name
Triethylamine hydrochloride
Purity
≥99.0% (AT)
Packaging
50g
Price
$45.1
Updated
2024/03/01
Sigma-Aldrich
Product number
90350
Product name
Triethylamine hydrochloride
Purity
≥99.0% (AT)
Packaging
1kg
Price
$176
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21135
Product name
Triethylammonium chloride
Purity
for synthesis
Packaging
5G
Price
$40.9
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21135
Product name
Triethylammonium chloride
Purity
for synthesis
Packaging
250g
Price
$65.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.21135
Product name
Triethylammonium chloride
Purity
for synthesis
Packaging
1kg
Price
$223
Updated
2024/03/01
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Triethylamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystalline powder

Uses

Triethylamine Hydrochloride is a hydrochloride salt of triethyllamine (T775740). Triethylamine is used as a competing base for the separation of acidic basic and neutral drugs by reverse-phased high-performance liquid chromatography (HPLC). Triethylamine induces visual disturbances (such as foggy vision) in humans, and is also used in industry as a quenching agent in the ozonolysis of alkenes (e.g. (E)-2-Pentene [P227315]). Triethylamine is used in the purification of drugs which are pharmacologically or chemically similar through separation in reverse-phase HPLC (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.

Hazard

Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system. Targets the central nervous system, liver, kidneys, and heart. Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Harmful if ingested or inhaled. Minimize exposure to this material. Severe overexposure can result in injury or death.

Safety Profile

Moderately toxic by subcutaneousroute. When heated to decomposition it emits toxicvapors of NOx, HCl, and Clí.

Solubility in organics

Soluble in ethanol, chloroform, and alcohol. Insoluble in ether.

Purification Methods

Purify it like the bromide above. [Beilstein 4 IV 327.]

References

[1] C Spagnuolo. “Gel filtration and reactivity of sulphydryl groups of human hemoglobin in concentrated triethylamine hydrochloride solutions.” The Italian journal of biochemistry 21 4 (1972): 221–9.
[2] G. Tian, Qi-Li Yuan, Huanhuan Du. “The Effects of Benzene on the Structure and Properties of Triethylamine Hydrochloride/Chloroaluminate.” Crystals 6 1 (2021).
[3] Zhe Zhang. “Solubility Determination and Model Evaluation of Triethylamine Hydrochloride in Three Binary Mixed Solvents.” Journal of Solution Chemistry 53 10 (2024): 1353–1373.
[4] Junfeng Teng . “Measurement, correlation, and analysis of the solubility of triethylamine hydrochloride in ten pure solvents.” Journal of Molecular Liquids 390 (2023): Article 123040.

Triethylamine hydrochloride Preparation Products And Raw materials

Raw materials

Triethylamine

Preparation Products

2-(4-Chloromethylpiperidin-1-yl)pyrimidine-5-carboxamide ,97% Triethylenethiophosphoramide 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbaldehyde 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxamide 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonyl chloride Cefotaxime sodium HEPTENOPHOS 1-(5-(Hydroxymethyl)pyrimidin-2-yl)piperidin-4-ol Lisinopril Dihydrate 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxylic acid 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carbonitrile (2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidin-5-yl)methanol 2-(4-Methylpiperazin-1-yl)pyrimidine-5-carboxamide Ethyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate Phosazetim 2-(4-(Hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate Ethyl 2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylate 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine N,O-Bis(trimethylsilyl)acetamide Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)pyrimidine-5-carboxylate (2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanol 2-Chloropyrimidine-5-carboxylic acid 2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)pyrimidine-5-carboxylate Triazophos Atracurium besylate 2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxamide (2-(4-Methylpiperazin-1-yl)pyrimidin-5-yl)methanamine
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Triethylamine hydrochloride Suppliers

Belgium 4 China 427 Czech Republic 1 Europe 3 Germany 7 India 61 Italy 1 Japan 5 Poland 1 Slovakia 1 Switzerland 4 United Kingdom 11 United States 39 Global 565
Discovery Fine Chemicals Ltd.
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Melrob Ltd (part of Nordmann)
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Apollo Scientific Ltd
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Cenik Chemicals
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Molekula Limited
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Apollo Scientific Ltd.
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Whyte Chemicals
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Leancare Ltd.
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Eurolabs Limited
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MOLEKULA Ltd.
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VWR International
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View Lastest Price from Triethylamine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Triethylamine Hydrochloride 554-68-7
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-12-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Triethylamine hydrochloride 554-68-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
20 tons
Release date
2021-07-30
Hebei Weibang Biotechnology Co., Ltd
Product
Triethylamine hydrochloride 554-68-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-12

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