ChemicalBook > CAS DataBase List > Ethyl L-phenylalaninate hydrochloride
Ethyl L-phenylalaninate hydrochloride
- Product Name
- Ethyl L-phenylalaninate hydrochloride
- CAS No.
- 3182-93-2
- Chemical Name
- Ethyl L-phenylalaninate hydrochloride
- Synonyms
- ETHYL 2-AMINO-3-PHENYLPROPANOATE HYDROCHLORIDE;Phe-OEt HCl;L-Phe-OEt.HCL;H-PHE-OET HCL;H-L-Phe-OEt*HCl;Ethyl L-phenylalanin;PHENYLALANINE-OET HCL;L-phenylalanine ethylester;L-PHANYLALANINEETHYLESTERHCL;L-PhenylalanineEthylEster>99%
- CBNumber
- CB0776127
- Molecular Formula
- C11H16ClNO2
- Formula Weight
- 229.7
- MOL File
- 3182-93-2.mol
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Ethyl L-phenylalaninate hydrochloride Property
- Melting point:
- 155-156 °C(lit.)
- alpha
- 33.7 º (c=2, C2H5OH 21 ºC)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Methanol, Water
- form
- Fine Needle-Like Crystalline Solid
- color
- White
- optical activity
- [α]20/D 7.8°, c = 2 in H2O
- Water Solubility
- Soluble in methanol and water.
- Sensitive
- Hygroscopic
- BRN
- 3657823
- InChI
- InChI=1/C11H15NO2.ClH/c1-2-14-11(13)10(12)8-9-6-4-3-5-7-9;/h3-7,10H,2,8,12H2,1H3;1H/t10-;/s3
- InChIKey
- FPFQPLFYTKMCHN-MEQOOBBNNA-N
- SMILES
- C1(C=CC=CC=1)C[C@H](N)C(=O)OCC.Cl |&1:7,r|
- CAS DataBase Reference
- 3182-93-2(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-26
- WGK Germany
- 3
- HS Code
- 29224995
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 220701
- Product name
- L-Phenylalanine ethyl ester hydrochloride
- Purity
- 99%
- Packaging
- 10g
- Price
- $61.6
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 220701
- Product name
- L-Phenylalanine ethyl ester hydrochloride
- Purity
- 99%
- Packaging
- 50g
- Price
- $287.7
- Updated
- 2025/07/31
TCI Chemical
- Product number
- P1949
- Product name
- Ethyl L-Phenylalaninate Hydrochloride
- Packaging
- 5G
- Price
- $43
- Updated
- 2025/07/31
TCI Chemical
- Product number
- P1949
- Product name
- Ethyl L-Phenylalaninate Hydrochloride
- Packaging
- 25G
- Price
- $86
- Updated
- 2025/07/31
Usbiological
- Product number
- 164695
- Product name
- L-Phenylalanine Ethyl Ester Hydrochloride
- Packaging
- 1g
- Price
- $319
- Updated
- 2021/12/16
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Ethyl L-phenylalaninate hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Crystalline
Uses
L-Phenylalanine Ethyl Ester Hydrochloride is an derivative of L-Phenylalanine (P319415), an essential amino acid.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
64-17-5
63-91-2
3182-93-2
1. L-phenylalanine (5 g, 30 mmol) was dissolved in anhydrous ethanol (30 mL). 2. slowly add trimethylchlorosilane (TMSCl, 6.915 mL, 54 mmol) to the reaction system at room temperature. 3. A reflux condenser was assembled and the reaction system was heated in an oil bath at 80 °C. 4. 4. The reaction mixture was allowed to react overnight under stirring conditions. 5. On the following day, the reaction system was cooled to room temperature and the reaction solution was subsequently concentrated under reduced pressure. 6. 6. The concentrated residue was dissolved in ether (Et2O). 7. The resulting slurry was filtered and the separated solid product was further washed with ether. 8. The washed solid was dried under high vacuum to afford the target product (S)-ethyl 2-amino-3-phenylpropionate hydrochloride (6.86 g, 99% yield). 9. The structure of the product was confirmed by 1H NPD analysis. 9. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ8.52 (s, 3H), 7.30 (m, 5H), 4.24 (ABX, JAX=7.8 Hz, JBX=6.2 Hz, 1H), 4.11 (m, 2H), 3.17, 3.05 (ABX, JAB=-14 Hz, JBX=5.8 Hz, JAX=7.6 Hz, 2H), 1.09 (t, J=6.8 Hz, 3H).
References
[1] Patent: US2017/71964, 2017, A1. Location in patent: Paragraph 0594-0595
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
[3] Tetrahedron Letters, 2015, vol. 56, # 49, p. 6900 - 6903
[4] Chemical Communications, 2011, vol. 47, # 42, p. 11784 - 11786
[5] Recueil des Travaux Chimiques des Pays-Bas, 1990, vol. 109, # 7/8, p. 413 - 418
Ethyl L-phenylalaninate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl L-phenylalaninate hydrochloride manufacturers
Sichuan HongRi Pharma-Tech Co.,Ltd
- Product
- H-L-Phe-OEt.HCl 3182-93-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-22
Shaanxi Dideu Medichem Co. Ltd
- Product
- Ethyl L-phenylalaninate hydrochloride 3182-93-2
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-08
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Ethyl L-phenylalaninate hydrochloride 3182-93-2
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
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