4-Chloro-3-nitrobenzenesulfonyl chloride

Product Name: 4-Chloro-3-nitrobenzenesulfonyl chloride
CAS No.: 97-08-5
Chemical Name: 4-Chloro-3-nitrobenzenesulfonyl chloride
Synonyms: Yel;4-CHLORO-3-NITROBENZENESULPHONYL CHLORIDE;4-CHLORO-3-NITROBENZENE-1-SULFONYL CHLORIDE;4-Chloro-3-nitrobenz;YELLOW SULFON CHLORIDE;3-Nitro-4-chlorobenzensulfonyl;4-Chloro-3-nitrobenzenesulfonyl;3-nitro-4-chlorosulfonyl chloride;3-NITRO-4-CHLOROBENZENSULFONYL CHLORIDE;4-chloro-3-nitro-benzenesulfonylchlorid
CBNumber: CB0776970
Molecular Formula: C6H3Cl2NO4S
Formula Weight: 256.06
MOL File: 97-08-5.mol

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4-Chloro-3-nitrobenzenesulfonyl chloride Property

Melting point:: 59-60 °C (lit.)
Boiling point:: 356°C (rough estimate)
Density: 1.696 (estimate)
refractive index: 1.6000 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Toluene
form: Crystalline Powder
color: Light brown
Sensitive: Moisture Sensitive
BRN: 1978600
CAS DataBase Reference: 97-08-5(CAS DataBase Reference)
NIST Chemistry Reference: Benzenesulfonyl chloride, 4-chloro-3-nitro-(97-08-5)
EPA Substance Registry System: Benzenesulfonyl chloride, 4-chloro-3-nitro- (97-08-5)

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Safety

Hazard Codes: C
Risk Statements: 34-29-14
Safety Statements: 26-27-28-36/37/39-45-8-30-22
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
Hazard Note: Corrosive
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29049090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C59408
Product name: 4-Chloro-3-nitrobenzenesulfonyl chloride
Purity: 96%
Packaging: 25g
Price: $37.6
Updated: 2023/06/20

TCI Chemical

Product number: C1887
Product name: 4-Chloro-3-nitrobenzenesulfonyl Chloride
Purity: >96.0%(GC)(T)
Packaging: 5g
Price: $93
Updated: 2025/07/31

TCI Chemical

Product number: C1887
Product name: 4-Chloro-3-nitrobenzenesulfonyl Chloride
Purity: >96.0%(GC)(T)
Packaging: 25g
Price: $299
Updated: 2025/07/31

TRC

Product number: C350280
Product name: 4-Chloro-3-nitrobenzenesulfonyl chloride
Packaging: 1g
Price: $55
Updated: 2021/12/16

TRC

Product number: C350280
Product name: 4-Chloro-3-nitrobenzenesulfonyl chloride
Packaging: 5g
Price: $65
Updated: 2021/12/16

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4-Chloro-3-nitrobenzenesulfonyl chloride Chemical Properties,Usage,Production

Chemical Properties

LIGHT BROWN CRYSTALLINE POWDER

Uses

4-Chloro-3-nitrobenzenesulfonyl Chloride is used in the synthesis of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones which increases melanin synthesis in murine B16 cells.

Uses

4-Chloro-3-nitrobenzenesulfonyl chloride can be used:

In the preparation of functionalized 1H-indenes via copper-catalyzed arylative cyclization.
As a precursor in the synthesis of N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives that show potential nematicidal activity.
As a key starting material in the synthesis of sulfonamide analogs of ferrostatin-1 (fer-1), which possess good ferroptosis inhibition property.
In the synthesis of 4-chloro-3-nitrobenzene thiol.

Synthesis

6671-49-4

97-08-5

Synthesis Example 2-2 Synthesis of 4-chloro-3-nitrobenzenesulfonyl chloride: to a reaction vial containing a mixture of 1280 g of potassium 4-chloro-3-nitrobenzenesulfonate, 1150 mL of acetonitrile, 250 mL of sulfoxide, and 30 mL of dimethylacetamide, 1240 mL of phosphinic acid chloride was added dropwise at a slow rate, while controlling the temperature within the reaction system to maintain a temperature of 60°C to 70°C. After the dropwise addition was completed, the reaction mixture was stirred at 73°C for 3 hours. Upon completion of the reaction, the reaction mixture was cooled with water, followed by the slow addition of 400 mL of water. The reaction mixture was poured into 5 L of ice water and the precipitated crystals were separated by filtration, washed with water and dried to give 1060 g of the target product 4-chloro-3-nitrobenzenesulfonyl chloride in 84% yield. The melting point of the product was 55 °C to 56 °C.

References

[1] Patent: US5221750, 1993, A
[2] Patent: US5071994, 1991, A

4-Chloro-3-nitrobenzenesulfonyl chloride Preparation Products And Raw materials

Raw materials

2-Nitrochlorobenzene Sulfuryl chloride

Preparation Products

5-[[4-(aminosulphonyl)-2-nitrophenyl]amino]-2-[[4-[[4-(aminosulphonyl)-2-nitrophenyl]amino]phenyl]amino]benzenesulphonic acid

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4-Chloro-3-nitrobenzenesulfonyl chloride Suppliers

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View Lastest Price from 4-Chloro-3-nitrobenzenesulfonyl chloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Chloro-3-nitrobenzenesulfonyl chloride 97-08-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000KG
Release date: 2024-08-15

Hebei Zhanyao Biotechnology Co. Ltd

Product: 4-Chloro-3-nitrobenzenesulfonyl chloride 97-08-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Chloro-3-nitrobenzenesulfonyl chloride 97-08-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

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4-Chloro-3-nitrobenzenesulfonyl chloride ISO 9001：2015 REACH

-Chloro-3-nitrobenzenesulfonyl Chloride

97-08-5

1997-08-05

1997-8-5

35-64-7

1997-08-5

C6H3NO4SCl2

ClC6H3NO2SO2Cl

SULFONYL CHLORIDE

Organic Building Blocks

Sulfonyl Halides

Sulfur Compounds

Building Blocks

Chemical Synthesis

Organic Building Blocks

Sulfonyl Halides

Sulfur Compounds

Benzene derivates

Organic Building Blocks

Sulfonyl Halides

Sulfur Compounds

Intermediates of Dyes and Pigments