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Benactyzine

Product Name
Benactyzine
CAS No.
302-40-9
Chemical Name
Benactyzine
Synonyms
Benactyzin;benactyzine;Benactyzine USP/EP/BP;Flamprop-methyl Impurity 8;Diethylaminoethyl benzilate;IVQOFBKHQCTVQV-UHFFFAOYSA-N;2-Diethylaminoethyl benzilate;Benzilic acid, 2-(diethylamino)ethyl ester;Benactyzine (base and/or unspecified salts);Diphenylglycolic acid 2-(diethylamino)ethyl ester
CBNumber
CB0854797
Molecular Formula
C20H25NO3
Formula Weight
327.42
MOL File
302-40-9.mol
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Benactyzine Property

Melting point:
51°
Boiling point:
465.31°C (rough estimate)
Density 
1.1392 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
2-8°C
pka
11.31±0.29(Predicted)
NIST Chemistry Reference
Benactyzine(302-40-9)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
Hazardous Substances Data
302-40-9(Hazardous Substances Data)
Toxicity
human,TDLo,intramuscular,100ug/kg (0.1mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE,"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0008980
Product name
BENACTYZINE
Purity
95.00%
Packaging
5MG
Price
$500.93
Updated
2021/12/16
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Benactyzine Chemical Properties,Usage,Production

Originator

Suavitil,Merck Sharp and Dohme,US,1957

Definition

ChEBI: 2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester is a diarylmethane.

Manufacturing Process

114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part of metallic sodium were placed in a flask attached to a total-reflux variable take-off fractionating column. The pressure was reduced to 100 mm and heat was applied by an oil bath the temperature of which was slowly raised to 90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C). When the distillation of the ethanol became slow, the bath temperature was raised to 120°C. When the vapor temperature indicated distillation of the amino alcohol the take off valve was closed and the mixture was refluxed for one hour. At the end of this period the vapor temperature had dropped and two more parts of ethanol were distilled, The remaining aminoalcohol was slowly distilled for three hours. The pressure was then reduced to 20 mm and the remainder of the aminoalcohol distilled at 66°C. During the reaction the color of the solution changed from yellow to deep red. The residue was dissolved in 500 parts of ether, washed once with dilute brine, and three times with water, dried over sodium sulfate and finally dried over calcium sulfate. 500 parts of a saturated solution of HCl in absolute ether was added and the resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a slight excess and the precipitate again filtered. The combined precipitates were washed with cold acetone. The 106 parts of product was purified by recrystallization from acetone as fine white crystals which melt at 177°- 178°C.

Therapeutic Function

Tranquilizer; Anticholinergic

Benactyzine Preparation Products And Raw materials

Raw materials

Preparation Products

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Benactyzine Suppliers

Eurolabs Limited
Tel
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Fax
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Country
United Kingdom
ProdList
6309
Advantage
46

302-40-9, BenactyzineRelated Search:


  • 2-diethylaminoethyl 2-hydroxy-2,2-diphenyl-acetate
  • benactyzine
  • Benactyzine (base and/or unspecified salts)
  • 2-Diethylaminoethyl benzilate
  • Benzilic acid, 2-(diethylamino)ethyl ester
  • Diethylaminoethyl benzilate
  • Benactyzin
  • Diphenylglycolic acid 2-(diethylamino)ethyl ester
  • α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl
  • α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
  • 2-diethylaminoethyl 2-hydroxy-2,2-di(phenyl)ethanoate
  • 2-hydroxy-2,2-di(phenyl)acetic acid 2-diethylaminoethyl ester
  • IVQOFBKHQCTVQV-UHFFFAOYSA-N
  • Benzeneacetic acid, α-hydroxy-α-phenyl-, 2-(diethylamino)ethyl ester
  • Benactyzine USP/EP/BP
  • Flamprop-methyl Impurity 8
  • 302-40-9