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Valganciclovir

Product Name
Valganciclovir
CAS No.
175865-60-8
Chemical Name
Valganciclovir
Synonyms
Valgancyclovir;Valganciclov;valganciclovir;Valganciclovir-d8;Valganciclovir-d8 (Mixture of Diastereomers);Valganciclovir & Valganciclovir Hydrochloride;Valganciclovir-d5 HCl (Mixture of diastetroMers);L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester;(2S)-2-((2-AMino-6-oxo-1H-purin-9(6H)-yl)Methoxy)-3-hydroxypropyl 2-aMino-3-Methylbutanoate;2-amino-3-methylbutanoic acid [2-[(2-amino-6-oxo-3H-purin-9-yl)methoxy]-3-hydroxypropyl] ester
CBNumber
CB0855239
Molecular Formula
C14H22N6O5
Formula Weight
354.36
MOL File
175865-60-8.mol
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Valganciclovir Property

Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
9.32±0.20(Predicted)
BCS Class
3
InChI
InChI=1S/C14H22N6O5/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22)/t8?,9-/m0/s1
InChIKey
WPVFJKSGQUFQAP-GKAPJAKFSA-N
SMILES
C(OCC(OCN1C2=C(N=C1)C(=O)NC(N)=N2)CO)(=O)[C@H](C(C)C)N
CAS DataBase Reference
175865-60-8(CAS DataBase Reference)
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Safety

Hazardous Substances Data
175865-60-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Medical Isotopes, Inc.
Product number
33627
Product name
Valganciclovir
Purity
98%purewithdatedHPLCUVchromatogram
Packaging
1mg
Price
$685
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0004848
Product name
VALGANCICLOVIR
Purity
95.00%
Packaging
0.25G
Price
$764
Updated
2021/12/16
Matrix Scientific
Product number
097028
Product name
(2S)-2-((2-Amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl 2-amino-3-methylbutanoate
Purity
95+%
Packaging
1g
Price
$807
Updated
2021/12/16
AK Scientific
Product number
Y0321
Product name
Valganciclovir
Packaging
1g
Price
$1139
Updated
2021/12/16
Matrix Scientific
Product number
097028
Product name
(2S)-2-((2-Amino-6-oxo-1H-purin-9(6H)-yl)methoxy)-3-hydroxypropyl 2-amino-3-methylbutanoate
Purity
95+%
Packaging
250mg
Price
$364
Updated
2021/12/16
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Valganciclovir Chemical Properties,Usage,Production

Uses

Antiviral.

Uses

Valganciclovir-d8, is the labeled analogue of Valganciclovir (V092000), a pro-drug of Ganciclovir, used in treatment of retro-virus.

Definition

ChEBI: The L-valinyl ester of ganciclovir, into which it is rapidly converted by intestinal and hepatic esterases. It is a synthetic analogue of 2'-deoxyguanosine.

Indications

Valganciclovir (Valcyte) is the L-valyl ester prodrug of ganciclovir.

brand name

Valcyte (Roche).

Clinical Use

Oral valganciclovir is comparable to intravenous ganciclovir for the treatment and suppression of CMV retinitis in AIDS patients.

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: increased risk of convulsions with imipenem-cilastatin.
Antivirals: possibly increased didanosine concentration; profound myelosuppression with zidovudine - avoid if possible.
Mycophenolate: possibly increased concentrations of both mycophenolic acid and ganciclovir.
Increased risk of myelosuppression with other myelosuppressive drugs.

Metabolism

Valganciclovir is well absorbed from the gastrointestinal tract and rapidly and extensively metabolised in the intestinal wall and liver to ganciclovir. Valganciclovir is eliminated in the urine as unchanged ganciclovir, mainly by glomerular filtration and also active tubular secretion.

Valganciclovir Preparation Products And Raw materials

Raw materials

Preparation Products

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Valganciclovir Suppliers

China 90 Europe 2 Germany 1 India 17 Italy 1 United Kingdom 1 United States 15 Global 127
farchemia srl
Tel
--
Fax
--
Email
duilio.ferri@farchemia.it
Country
Italy
ProdList
59
Advantage
66
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View Lastest Price from Valganciclovir manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Valganciclovir 175865-60-8
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99% HPLC
Supply Ability
10000
Release date
2024-09-11
Sinoway Industrial co., ltd.
Product
Valganciclovir 175865-60-8
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
99% up, High Density
Supply Ability
20 tons
Release date
2021-07-14
Henan Aochuang Chemical Co.,Ltd.
Product
Valganciclovir 175865-60-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29

175865-60-8, ValganciclovirRelated Search:

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  • API