1H-INDOLE-5-CARBOXAMIDE, 97%

Product Name: 1H-INDOLE-5-CARBOXAMIDE, 97%
CAS No.: 1670-87-7
Chemical Name: 1H-INDOLE-5-CARBOXAMIDE, 97%
Synonyms: SD-169;5-CarbaMoylindole;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-INDOLE-5-CARBOXAMIDE, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI);p38 MAP Kinase Inhibitor VII, SD-169;p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem;5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
CBNumber: CB0972248
Molecular Formula: C9H8N2O
Formula Weight: 160.17
MOL File: 1670-87-7.mol

More

Less

1H-INDOLE-5-CARBOXAMIDE, 97% Property

Melting point:: 159-163 °C
Boiling point:: 457.6±18.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Off-white solid
pka: 16.25±0.30(Predicted)
color: Off-White to Light Purple

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 506158
Product name: p38 MAP Kinase Inhibitor VII, SD-169
Packaging: 10mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 25mg
Price: $142
Updated: 2024/03/01

TRC

Product number: I615500
Product name: 1H-Indole-5-carboxamide
Packaging: 10g
Price: $950
Updated: 2021/12/16

More

Less

1H-INDOLE-5-CARBOXAMIDE, 97% Chemical Properties,Usage,Production

Uses

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.

Uses

1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.

Definition

ChEBI: 1H-indole-5-carboxamide is an indolecarboxamide.

Biological Activity

Selective, orally active, ATP-competitive inhibitor of p38 α MAPK (IC 50 values are 3.2, 122 and > 50000 nM for p38 α , p38 β and p38 γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

References

[1] medicherla s, protter a a, ma j y, et al. preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes[j]. journal of pharmacology and experimental therapeutics, 2006, 318(1): 99-107.
[2] myers r r, sekiguchi y, kikuchi s, et al. inhibition of p38 map kinase activity enhances axonal regeneration[j]. experimental neurology, 2003, 184(2): 606-614.

1H-INDOLE-5-CARBOXAMIDE, 97% Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1H-INDOLE-5-CARBOXAMIDE, 97% Suppliers

Canada 1 China 71 Europe 1 Germany 1 India 2 Switzerland 1 The Netherlands 1 United Kingdom 2 United States 21 USA 1 Global 102

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63711
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354
Email: support@targetmol.com
Country: United States
ProdList: 19973
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: sales@advtechind.com
Country: United States
ProdList: 6106
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6254
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6824
Advantage: 0

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6618
Advantage: 81

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6632
Advantage: 69

Axon Medchem LLC

Tel: --
Fax: --
Email: info@axonmedchem.com
Country: United States
ProdList: 763
Advantage: 58

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6825
Advantage: 87

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6655
Advantage: 80

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6826
Advantage: 51

Enzo Life Sciences International Inc.

Tel: --
Fax: --
Email: info-usa@enzolifesciences.com
Country: United States
ProdList: 39
Advantage: 60

Sphinx Scientific Laboratory, LLC

Tel: --
Fax: --
Email: sales@sphinxscientificlab.com
Country: United States
ProdList: 3347
Advantage: 50

Best PharmaTech, Inc.

Tel: --
Fax: --
Email: info@bestpharmatech.com
Country: United States
ProdList: 867
Advantage: 50

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3602
Advantage: 60

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6740
Advantage: 64

More

Less

View Lastest Price from 1H-INDOLE-5-CARBOXAMIDE, 97% manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1H-INDOLE-5-CARBOXAMIDE 1670-87-7
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

Nanjing jinheyou Trading Co., Ltd.

Product: 1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-20

1670-87-7, 1H-INDOLE-5-CARBOXAMIDE, 97%Related Search:

3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole SD-208 FROVATRIPTAN GO 6976 K-252A 4'-demethylamino-4'-hydroxystaurosporine STAUROSPORINE ANTIBIOTIC UCN-02 1-BENZYL-2,3-DIMETHYL-1H-INDOLE-5-CARBOHYDRAZIDE 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE K-252C N-ethoxycarbonyl-7-oxostaurosporine 5-CARBOXAMIDOTRYPTAMINE, [1,2-3H]- 5-CARBOXAMIDO[3H]TRYPTAMINE, TRIFLUOROACETATE 5-carboxamidotryptamine maleate salt 2,3-DIMETHYL-1 H-INDOLE-5-CARBOXYLIC ACID HYDRAZIDE TAN 999 N,N-DIPROPYL-5-CARBOXAMIDOTRYPTAMINE MALEATE

1H-INDOLE-5-CARBOXAMIDE, 97%

SD-169

1H-Indole-5-carboxamide(9CI)

5-(AMinocarbonyl)-1H-indole

5-CarbaMoylindole

p38 MAP Kinase Inhibitor VII, SD-169

5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole

p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem

Indole-5-carboxamide (7CI, 8CI)

HSPs,p38α,kinases,SD-169,protein,inhibit,Inhibitor,p38 MAPK,MAPK,SD169,heat,diabete,mitogen-activated,proteins,shock

1H-indole-5-carboxamide(SD-169)

1670-87-7

AMIDE

Heterocyclic Compounds