2-Bromo-4'-methylacetophenone

Product Name: 2-Bromo-4'-methylacetophenone
CAS No.: 619-41-0
Chemical Name: 2-Bromo-4'-methylacetophenone
Synonyms: NSC-63192;omega-Bro;ETHYL-P-TOLYLKETON;P-TOLYL ETHYL KETONE;Zolpidem Impurity 54;LABOTEST-BB LT00053050;p-Methylphenacyl bromide;2-bromo-1-p-tolylethanone;4-Methylphenacylbromide98%;Bromomethyl p-tolyl ketone
CBNumber: CB1116041
Molecular Formula: C9H9BrO
Formula Weight: 213.07
MOL File: 619-41-0.mol

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2-Bromo-4'-methylacetophenone Property

Melting point:: 45-49 °C(lit.)
Boiling point:: 238-239 °C(lit.)
Density: 0.993 g/mL at 25 °C(lit.)
refractive index: n20/D 1.528(lit.)
Flash point:: 229 °F
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate
form: Crystalline Powder or Needles
color: White to light yellow
BRN: 607041
Stability:: Stable. Incompatible with strong oxidizing agents, strong bases.
InChI: InChI=1S/C9H9BrO/c1-7-2-4-8(5-3-7)9(11)6-10/h2-5H,6H2,1H3
InChIKey: KRVGXFREOJHJAX-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(C)C=C1)CBr
CAS DataBase Reference: 619-41-0(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 2-bromo-1-(4-methylphenyl)-(619-41-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-27-37/39
RIDADR: UN 2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 159530
Product name: 2-Bromo-4′-methylacetophenone
Purity: 90%
Packaging: 5g
Price: $40.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 159530
Product name: 2-Bromo-4′-methylacetophenone
Purity: 90%
Packaging: 25g
Price: $193
Updated: 2025/07/31

TCI Chemical

Product number: B2107
Product name: 2-Bromo-4'-methylacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: B2107
Product name: 2-Bromo-4'-methylacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $76
Updated: 2025/07/31

Sigma-Aldrich

Product number: 159530
Product name: 2-Bromo-4′-methylacetophenone
Purity: 90%
Packaging: 100g
Price: $333
Updated: 2023/06/20

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2-Bromo-4'-methylacetophenone Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powder

Uses

2-Bromo-4′-methylacetophenone was used in the general fluorous thiol quenching method. It was also used in the preparation of hydroxyquinolinone and N-derivatized carboxamides.

General Description

2-Bromo-4′-methylacetophenone is an α-bromoketone.

Synthesis

622-97-9

619-41-0

General procedure: 4-methylstyrene (1 mmol) was dissolved in a solvent mixture of acetone (3 mL) and water (0.1 mL) at room temperature. Subsequently, dibromo-p-toluenesulfonamide (TsNBr2, 2.2 mmol) was slowly added to this solution. After the reaction was complete, sodium thiosulfate (~200 mg) was added to quench the reaction and stirring was continued for 10 minutes. The reaction mixture was extracted with ethyl acetate and the organic phase was dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography on silica gel (230-400 mesh), the eluent being a mixed petroleum ether-ethyl acetate solvent, to give the final pure 2-bromo-4'-methylacetophenone.

References

[1] Tetrahedron Letters, 2015, vol. 56, # 2, p. 356 - 358
[2] Organic and Biomolecular Chemistry, 2016, vol. 14, # 48, p. 11389 - 11395
[3] Green Chemistry, 2013, vol. 15, # 8, p. 2175 - 2179
[4] Synlett, 2010, # 15, p. 2335 - 2339
[5] Organic Letters, 2015, vol. 17, # 11, p. 2704 - 2707

2-Bromo-4'-methylacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

3-(4-METHYLPHENYL)ISOXAZOL-5-AMINE

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2-Bromo-4'-methylacetophenone Suppliers

Americas 1 Belgium 3 Canada 4 China 202 Europe 3 Finland 1 Germany 6 India 31 Israel 2 Japan 1 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 Ukraine 4 United Kingdom 16 United States 29 Global 309

Tosoh Europe B.V.

Tel: --
Fax: --
Email: info.tse@tosoh.com
Country: The Netherlands
ProdList: 130
Advantage: 58

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View Lastest Price from 2-Bromo-4'-methylacetophenone manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-bromo-4'-methylacetophenone 619-41-0
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromo-4'-methylacetophenone 619-41-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-10

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Bromo-4'-methylacetophenone 619-41-0
Price: US $30.00-10.00/kg
Min. Order: 10kg
Purity: 99%
Supply Ability: 100000kg
Release date: 2024-08-14

619-41-0, 2-Bromo-4'-methylacetophenoneRelated Search:

4'-Methylacetophenone 3'-Methylacetophenone Acetophenone 2',4'-Dichloroacetophenone 4'-Hydroxyacetophenone Chalcone 4'-(Trifluoromethyl)acetophenone PIPERACETAZINE (250 MG) 3-Nitroacetophenone 4'-Bromoacetophenone 2-Bromoacetophenone 4-(Trifluoromethyl)phenacyl bromide 2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE Methyl bromide 2-BROMO-4'-PHENYLACETOPHENONE 2-BROMO-1-(3-CHLORO-4-METHYLPHENYL)PROPAN-1-ONE 4,4'-Bis(2-bromoacetyl)biphenyl Bromine

P-TOLYL ETHYL KETONE

ETHYL-P-TOLYLKETON

LABOTEST-BB LT00053050

2-Bromo-p-methylacetophenone

Acetophenone, 2-bromo-4'-methyl-

alpha-Bromo-4-methylacetophenone

alpha-Bromo-p-methylacetophenone

omega-Bromo-p-methylacetophenone

p-Methyl-alpha-bromoacetophenone

p-Methyl-omega-bromoacetophenone

p-Methylphenacyl bromide

4-Methylphenacylbromide98%

4-Methylphenacylbromide 98%

4'-Methyl-2-bromoacetophenone

à-bromo-4-methylacetophenone

2-BROMO-4-METHYLACETACETOPHENONE

2-Bromo-1-(4-methylphenyl)ethan-1-one

2-Bromo-4'-methylacetophenone

2-bromo-1-p-tolylethanone

a-Bromo-p-methylacetophenone

Bromomethyl p-tolyl ketone

1-(Bromoacetyl)-4-methylbenzene

2-Bromo-1-(4-tolyl)ethanone

NSC-63192

JR-8309, 2-Bromo-4'-methylacetophenone, 97%

2-Bromo-4'-methylacetophenone,97%

2-Bromo-4-methylacetaphenone

4-(Bromoacetyl)toluene 4-Methylphenacyl Bromide

omega-Bro

2-BroMo-4'-Methylacetophenone 90%

2-bromo-1-(p-tolyl)ethan-1-one

2-Bromo-4'-methylacetophenone&gt

Ethanone, 2-bromo-1-(4-methylphenyl)-

Zolpidem Impurity 54

2 - BROMINE - 4 '- METHYL ACETOPHENONE

2-Bromo-4′-methylacetophenone, 90%+

619-41-0

Carbonyl Compounds

C10

C9

Building Blocks

Ketones

Organic Building Blocks

Aromatics

Acetophenone series

C9

Carbonyl Compounds

Ketones

Aromatic Acetophenones & Derivatives (substituted)