Febrifugine
- Product Name
- Febrifugine
- CAS No.
- 24159-07-7
- Chemical Name
- Febrifugine
- Synonyms
- febrifugin;ferifugine;β-dichroine;Febrifugine;Radix Dichroae;(+)-Febrifugine;BETA-Febrifugine;Febrifugine USP/EP/BP;Febrifugine，Isofebrifugine;Febrifugine (6-Desoxyswietenine)
- CBNumber
- CB11178705
- Molecular Formula
- C16H19N3O3
- Formula Weight
- 301.34
- MOL File
- 24159-07-7.mol
Febrifugine Property
- Melting point:
- 139-140°; mp 154-156°
- alpha
- D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol)
- Density
- 1.39
- storage temp.
- 2-8°C
- solubility
- DMF: 1.5 mg/ml; DMSO: 3.0 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 2.5 mg/ml
- form
- A crystalline solid
- Boiling point:
- 508.2±60.0 °C(Predicted)
- pka
- 14.61±0.40(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 24159-07-7
Safety
- Toxicity
- LD50 orally in white mice: 2.5-3.0 mg/kg (Koepfli, 1949)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 14246
- Product name
- Febrifugine
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 14246
- Product name
- Febrifugine
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 300268
- Product name
- Febrifugine
- Packaging
- 20mg
- Price
- $665
- Updated
- 2021/12/16
- Product number
- CCH0003303
- Product name
- 3-[3-[3(S)-HYDROXYPIPERIDIN-2(R)-YL]-2-OXOPROPYL]-3,4-DIHYDROQUINAZOLIN-4-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $3854.55
- Updated
- 2021/12/16
- Product number
- CS-0022587
- Product name
- Febrifugine
- Packaging
- 5mg
- Price
- $336
- Updated
- 2021/12/16
Febrifugine Chemical Properties,Usage,Production
Description
Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.
Uses
Febrifugine is a quinazoline alkaloid with significant antimalarial and anticancerous efficacy. Febrifugine is an NRF2 inhibitor, that works with halofuginone for the treatment of chemo- and radio-resistant forms of cancer. Febrifugine analogs also functions as antimalarial, anticancer agents and in the prevention of chicken coccidiosis.
Febrifugine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Febrifugine manufacturers
- Product
- Febrifugine 24159-07-7
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09