ChemicalBook > CAS DataBase List > 2-Iodobenzoic acid

2-Iodobenzoic acid

Product Name
2-Iodobenzoic acid
CAS No.
88-67-5
Chemical Name
2-Iodobenzoic acid
Synonyms
O-IODOBENZOIC ACID;2-IODO BENZONIC ACID;NSC 3772;usafek-572;USAF ek-572;'LGC' (4009);O-iodine acid;IodobenzoicAcid;2-lodhenxoieacid;2-iodo-benzoicaci
CBNumber
CB1126640
Molecular Formula
C7H5IO2
Formula Weight
248.02
MOL File
88-67-5.mol
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2-Iodobenzoic acid Property

Melting point:
160-162 °C(lit.)
Boiling point:
313.9±25.0 °C(Predicted)
Density 
2.25
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in dimethyl sulfoxide and methanol
pka
2.85(at 25℃)
form 
Powder, Crystals or Flakes
color 
Light yellow to orange-brown
Water Solubility 
sparingly soluble
Sensitive 
Light Sensitive
Merck 
14,5030
BRN 
1861406
Stability:
Stable. Incompatible with strong oxidizing agents, strong bases.
InChIKey
CJNZAXGUTKBIHP-UHFFFAOYSA-N
CAS DataBase Reference
88-67-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzoic acid, 2-iodo-(88-67-5)
EPA Substance Registry System
Benzoic acid, 2-iodo- (88-67-5)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-37/38-41-36/37/38-20/21/22
Safety Statements 
26-39-24/25-22-36
WGK Germany 
3
RTECS 
DH2975000
Hazard Note 
Irritant
TSCA 
T
HazardClass 
IRRITANT, LIGHT SENSITIVE
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I7675
Product name
2-Iodobenzoic acid
Purity
98%
Packaging
25g
Price
$28.4
Updated
2024/03/01
Sigma-Aldrich
Product number
418463
Product name
2-Iodobenzoic acid
Purity
≥99%, purified by sublimation
Packaging
1G
Price
$34.6
Updated
2023/01/07
TCI Chemical
Product number
I0053
Product name
2-Iodobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
I0053
Product name
2-Iodobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$73
Updated
2024/03/01
Alfa Aesar
Product number
A10563
Product name
2-Iodobenzoic acid, 98+%
Packaging
25g
Price
$23.65
Updated
2024/03/01
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2-Iodobenzoic acid Chemical Properties,Usage,Production

Description

2-iodobenzoic acid and its derivatives are important pharmaceutical and chemical raw materials, which are necessary for the synthesis of various high-iodine reagents. It is commonly used as a precursor for the synthesis of 2-Iodoxybenzoic acid (IBX) and Dess-Martin peridinane, which are used as mild oxidants. It is also used in Suziki reaction.

Chemical Properties

white crystal powder. Soluble in alcohol and ether, insoluble in water.

Uses

Reagent for detection of sulfhydryl groups in proteins. 2-Iodobenzoic acid acts as a precursor in the preparation of 2-Iodoxybenzoic acid (IBX) and Dess-Martin periodinane, which finds application as an oxidizing agent in synthetic chemistry. It is also used in Suzuki reaction.

Preparation

2-Iodobenzoic acid is obtained from Anthranilic acid by diazotization and substitution. Diazotization of Anthranilic acid with sodium nitrite in the presence of sulfuric acid, control the temperature below 10℃, filter the diazotization solution, add the mixture of potassium iodide and sulfuric acid, stir for 10min after addition, and boil. Filter, wash with sodium thiosulfate solution, 2-Iodobenzoic acid can be recrystallized from water.

Definition

ChEBI: An iodobenzoic acid with a single iodo substituent placed at the 2-position.

Synthesis Reference(s)

Journal of the American Chemical Society, 93, p. 4841, 1971 DOI: 10.1021/ja00748a029

Purification Methods

Crystallise the acid repeatedly from water and EtOH. Sublime it under vacuum at 100o. [Beilstein 9 IV 1030.]

2-Iodobenzoic acid Preparation Products And Raw materials

Raw materials

Anthranilic acid

Preparation Products

2-IODOBENZOYL CHLORIDE Dess-Martin periodinane 2-Iodoxybenzoic acid 2'-IODOHIPPURIC ACID Flufenamic acid 2-Ethoxycarbonylphenylboronic acid pinacol ester
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View Lastest Price from 2-Iodobenzoic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Iodobenzoic acid 88-67-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-16
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Iodobenzoic acid 88-67-5
Price
US $100.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-04-24
Hebei Yanxi Chemical Co., Ltd.
Product
2-Iodobenzoic acid 88-67-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08

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