Wandonorm

Product Name: Wandonorm
CAS No.: 82857-38-3
Chemical Name: Wandonorm
Synonyms: LT 31-200;Wandonorm;Cyclobenzaprine-d;Bopindolol hydrogen malonate;Propanedioic acid, compd. with 2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1);Propanedioic acid, compd. with (+-)-2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1);2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), propanedioate (1:1) (salt) (9CI);2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), (+-)-, propanedioate (1:1) (salt)
CBNumber: CB11270445
Molecular Formula: C26H32N2O7
Formula Weight: 484.54148
MOL File: 82857-38-3.mol

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Wandonorm Property

storage temp.: Store at -20°C
solubility: Water: 5mM
form: White solid.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23365
Product name: Bopindolol (malonate)
Purity: ≥98%
Packaging: 100mg
Price: $91
Updated: 2024/03/01

Cayman Chemical

Product number: 23365
Product name: Bopindolol (malonate)
Purity: ≥98%
Packaging: 500mg
Price: $319
Updated: 2024/03/01

AK Scientific

Product number: 8608CC
Product name: Bopindololmalonate
Packaging: 500mg
Price: $434
Updated: 2021/12/16

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Wandonorm Chemical Properties,Usage,Production

Uses

Bopindolol ((±)-Bopindolol) malonate is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol malonate is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol malonate has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol malonate is a proagent of Pindolol (HY-B0982). Bopindolol malonate can be used for essential and renovascular hypertension research.

Definition

ChEBI: Bopindolol malonate is a benzoate ester.

in vivo

Bopindolol (intravenous injection; 8, 16 and 32 μg/kg) causes a dose-dependent inhibition of isoprenaline-induced tachycardia, and this agent is 4 times more potent than propranolol in anaesthetised dogs^[1]. Bopindolol (0.3, 1 and 3 mg/kg; IP; single dosage) produces dose dependent decreases in diastolic blood pressure and in heart rate^[2].

Animal Model:	Male Wistar rats (260-300 g)^[2]
Dosage:	0.3, 1 and 3 mg/kg
Administration:	IP; single dosage
Result:	Produced dose dependent decreases in diastolic blood pressure, and the decrease of about 8 mmHg at 3 mg/kg. Decreased the heart rate in a dose-dependent manner.

References

[1] Harron DW, et al. Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs. 1991 Jan;41(1):130-49. DOI:10.2165/00003495-199141010-00010
[2] H Tanaka, et al. Hypotensive effect of bopindolol in pithed rats. Gen Pharmacol. 1993 Mar;24(2):373-5. DOI:10.1016/0306-3623(93)90319-s
[3] Y Hosohata, et al. Bopindolol is a slowly dissociating beta 1-adrenoceptor antagonist when compared to other beta-blockers. Biol Pharm Bull. 1995 Aug;18(8):1066-71. DOI:10.1248/bpb.18.1066
[4] Nagatomo T, et al. Bopindolol: pharmacological basis and clinical implications. Cardiovasc Drug Rev. 2001 Spring;19(1):9-24. DOI:10.1111/j.1527-3466.2001.tb00180.x

Wandonorm Preparation Products And Raw materials

Raw materials

Preparation Products

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Wandonorm Suppliers

China 9 United States 5 Global 14

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
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HBCChem, Inc.

Tel: +1-510-219-6317
Fax: +1-650-486-1361
Email: sales@hbcchem.com
Country: United States
ProdList: 10648
Advantage: 60

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Cayman Chemical Company

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Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

HBCChem Inc.

Tel: --
Fax: --
Email: sales@hbcchem-inc.com
Country: United States
ProdList: 4569
Advantage: 30

82857-38-3, WandonormRelated Search:

Tizanidine Tizanidine hydrochloride Carvedilol (-)-CYANOPINDOLOL HEMIFUMARATE Propranolol hydrochloride GUANFACINE HCL L-NORADRENALINE BITARTRATE (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride Rauwolscine hydrochloride GUANFACINE HCL Bopindolol Ethyl benzoate

2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), (+-)-, propanedioate (1:1) (salt)

2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[(2-methyl-1H-indol-4-yl)oxy]-, benzoate (ester), propanedioate (1:1) (salt) (9CI)

Bopindolol hydrogen malonate

LT 31-200

Propanedioic acid, compd. with (+-)-2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1)

Propanedioic acid, compd. with 2-[(1,1-dimethylethyl)amino]-1-[[(2-methyl-1H-indol-4-yl)oxy]methyl]ethyl benzoate (1:1)

Wandonorm

Cyclobenzaprine-d

82857-38-3