ChemicalBook > CAS DataBase List > columbamine

columbamine

Product Name: columbamine
CAS No.: 3621-36-1
Chemical Name: columbamine
Synonyms: Columbamin;Dehydroisocorypalmine;Columbamine (Columbamin;Columbamine, 10 mM in DMSO;Inhibitor,Columbamine,inhibit;5,6-Dihydro-3,9,10-trimethoxydibenzo[a,g]quinolizinium-2-ol;5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium;Dibenzo[a,g]quinolizinium,5,6-dihydro-2-hydroxy-3,9,10-trimethoxy-;3,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2-ol;2-Hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium
CBNumber: CB11321390
Molecular Formula: [C20H20NO4]+.
Formula Weight: 0
MOL File: 3621-36-1.mol

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columbamine Property

Melting point:: 280-282℃ (methanol )
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: soluble
form: Powder
color: Light yellow to orange

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H402Harmful to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC74185
Product name: Columbamine
Packaging: 5mg
Price: $92
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC74185
Product name: Columbamine
Packaging: 10mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: 9161AF
Product name: Columbamine
Packaging: 1mg
Price: $174
Updated: 2021/12/16

ChemScene

Product number: CS-4254
Product name: Columbamine
Purity: 98.38%
Packaging: 5mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-4254
Product name: Columbamine
Purity: 98.38%
Packaging: 10mg
Price: $288
Updated: 2021/12/16

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columbamine Chemical Properties,Usage,Production

Chemical Properties

Orange-yellow crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from tomato rhizomes, leaves, green fruits, high in content, and low in mature fruits.

Uses

Columbamine has antibacterial, anti-inflammatory, antihistamine, cardiotonic, anticancer effects.

Definition

ChEBI: Columbamine is a berberine alkaloid and an organic heterotetracyclic compound.

Biological Activity

Columbamine is a quaternary isoquinoline alkaloid extracted from plants.

in vivo

Columbamine (5-20 mg/kg; 23 days) significantly decreases the tumor volumes in a dose-dependent manner in HCT116 xenograft mice model^[4].

Animal Model:	Six-weeks-old male BALB/c nude mice (subcutaneously injected with HCT116 and control cells on the opposite flanks of the same mouse)^[4]
Dosage:	5, 10, 20 mg/kg
Administration:	Administered to experimental mice for 23 days
Result:	Decreased the tumor volumes in a dose-dependent manner.

IC 50

CYP3A4: 30.6 μM (IC₅₀)

columbamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from columbamine manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Columbamine 3621-36-1
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-11

Career Henan Chemical Co

Product: columbamine 3621-36-1
Price: US $5.50/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1kg-100kg
Release date: 2020-01-10

3621-36-1, columbamineRelated Search:

Myricitrin Ammothamnine Senkyunolide H (3S)-3β-Butyl-1,3,4,5-tetrahydroisobenzofuran-1-one Palmatine Dehydrocorydaline Palmatine chloride hydrate Berberine BERBERINE SULFATE TRIHYDRATE Palmatine chloride BERBERINE CHLORIDE DIHYDRATE BERBERINE ACID SULFATE Dehydrocorydaline nitrate BERBERINE CHLORIDE columbamine AKOS 213-46 BERBERINE, ACETONE ADDUCT PALMATINE IODIDE

Dehydroisocorypalmine

5,6-Dihydro-2-hydroxy-3,9,10-trimethoxydibenzo[a,g]quinolizinium

5,6-Dihydro-3,9,10-trimethoxydibenzo[a,g]quinolizinium-2-ol

Columbamine (Columbamin

Columbamin

Dibenzo[a,g]quinolizinium,5,6-dihydro-2-hydroxy-3,9,10-trimethoxy-

3,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2-ol

Inhibitor,Columbamine,inhibit

2-Hydroxy-3,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium

Columbamine, 10 mM in DMSO

3621-36-1