SB 204741

ChemicalBook > CAS DataBase List > SB 204741

Product Name: SB 204741
CAS No.: 152239-46-8
Chemical Name: SB 204741
Synonyms: SB 204741;1-(1-methyl-5-indolyl)-3-(3-methyl-5-isothiazolyl)urea;3-(3-METHYL-1,2-THIAZOL-5-YL)-1-(1-METHYLINDOL-5-YL)UREA;N-(1-METHYL-1H-5-INDOLYL)-N'-(3-METHYL-5-ISOTHIAZOLYL)UREA;1-(1-Methyl-1H-indol-5-yl)-3-(3-Methylisothiazol-5-yl)urea;N-(1-METHYL-1H-INDOLYL-5-YL)-N''-(3-METHYL-5-ISOTHIAZOLYL)UREA;Urea, N-(1-methyl-1H-indol-5-yl)-N'-(3-methyl-5-isothiazolyl)-;human,inhibit,SB204741,5-HT Receptor,Inhibitor,remodeling,Serotonin Receptor,selective,SB 204741,isoproterenol-induced,affinity,SB-204741,5-hydroxytryptamine Receptor,myocardial
CBNumber: CB1207574
Molecular Formula: C14H14N4OS
Formula Weight: 286.35
MOL File: 152239-46-8.mol

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SB 204741 Property

Melting point:: >195°C (dec.)
storage temp.: 2-8°C
solubility: DMSO: ~18 mg/mL, soluble
form: solid
color: orange
Stability:: Hygroscopic

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S0693
Product name: SB 204741
Purity: >98% (HPLC)
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Sigma-Aldrich

Product number: S0693
Product name: SB 204741
Purity: >98% (HPLC)
Packaging: 50mg
Price: $858
Updated: 2024/03/01

Tocris

Product number: 1372
Product name: SB 204741
Purity: ≥99%(HPLC)
Packaging: 10
Price: $162
Updated: 2021/12/16

Tocris

Product number: 1372
Product name: SB 204741
Purity: ≥99%(HPLC)
Packaging: 50
Price: $682
Updated: 2021/12/16

TRC

Product number: S155025
Product name: SB 204741
Packaging: 100mg
Price: $120
Updated: 2021/12/16

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SB 204741 Chemical Properties,Usage,Production

Uses

SB 204741 is a potent, selective SR-2B antagonist.

Definition

ChEBI: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea is a member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It is a member of ureas, a member of indoles and a member of 1,2-thiazoles.

Biological Activity

Potent and selective 5-HT 2B receptor antagonist (pA 2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT 2C (pK i = 5.82), 5-HT 2A (pK i < 5.2), 5-HT 1A , 1D , 1E , 5-HT 3 and 5-HT 4 receptors.

storage

Room temperature

SB 204741 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 204741 Suppliers

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View Lastest Price from SB 204741 manufacturers

Career Henan Chemica Co

Product: SB 204741 152239-46-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: MIn98%HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-29

152239-46-8, SB 204741Related Search:

Sb-742457 SBI-0206965 SB9200 GSK-CXCR2 SBI-993 SB-649868 SB1317 SB 203580 SB1317 5-AMINO-3-METHYLISOTHIAZOLE HYDROCHLORIDE SB 204741 3-METHYLISOTHIAZOLE 5-AMINO-1-N-METHYLINDOLE

SB 204741

N-(1-METHYL-1H-5-INDOLYL)-N'-(3-METHYL-5-ISOTHIAZOLYL)UREA

N-(1-METHYL-1H-INDOLYL-5-YL)-N''-(3-METHYL-5-ISOTHIAZOLYL)UREA

1-(1-Methyl-1H-indol-5-yl)-3-(3-Methylisothiazol-5-yl)urea

3-(3-METHYL-1,2-THIAZOL-5-YL)-1-(1-METHYLINDOL-5-YL)UREA

1-(1-methyl-5-indolyl)-3-(3-methyl-5-isothiazolyl)urea

Urea, N-(1-methyl-1H-indol-5-yl)-N'-(3-methyl-5-isothiazolyl)-

human,inhibit,SB204741,5-HT Receptor,Inhibitor,remodeling,Serotonin Receptor,selective,SB 204741,isoproterenol-induced,affinity,SB-204741,5-hydroxytryptamine Receptor,myocardial

152239-46-8

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