ChemicalBook > CAS DataBase List > SB 204741

SB 204741

Product Name
SB 204741
CAS No.
152239-46-8
Chemical Name
SB 204741
Synonyms
SB 204741;1-(1-methyl-5-indolyl)-3-(3-methyl-5-isothiazolyl)urea;3-(3-METHYL-1,2-THIAZOL-5-YL)-1-(1-METHYLINDOL-5-YL)UREA;N-(1-METHYL-1H-5-INDOLYL)-N'-(3-METHYL-5-ISOTHIAZOLYL)UREA;1-(1-Methyl-1H-indol-5-yl)-3-(3-Methylisothiazol-5-yl)urea;N-(1-METHYL-1H-INDOLYL-5-YL)-N''-(3-METHYL-5-ISOTHIAZOLYL)UREA;Urea, N-(1-methyl-1H-indol-5-yl)-N'-(3-methyl-5-isothiazolyl)-;human,inhibit,SB204741,5-HT Receptor,Inhibitor,remodeling,Serotonin Receptor,selective,SB 204741,isoproterenol-induced,affinity,SB-204741,5-hydroxytryptamine Receptor,myocardial
CBNumber
CB1207574
Molecular Formula
C14H14N4OS
Formula Weight
286.35
MOL File
152239-46-8.mol
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SB 204741 Property

Melting point:
>195°C (dec.)
storage temp. 
2-8°C
solubility 
DMSO: ~18 mg/mL, soluble
form 
solid
color 
orange
Stability:
Hygroscopic
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S0693
Product name
SB 204741
Purity
>98% (HPLC)
Packaging
10mg
Price
$214
Updated
2024/03/01
Sigma-Aldrich
Product number
S0693
Product name
SB 204741
Purity
>98% (HPLC)
Packaging
50mg
Price
$858
Updated
2024/03/01
Tocris
Product number
1372
Product name
SB 204741
Purity
≥99%(HPLC)
Packaging
10
Price
$162
Updated
2021/12/16
Tocris
Product number
1372
Product name
SB 204741
Purity
≥99%(HPLC)
Packaging
50
Price
$682
Updated
2021/12/16
TRC
Product number
S155025
Product name
SB 204741
Packaging
100mg
Price
$120
Updated
2021/12/16
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SB 204741 Chemical Properties,Usage,Production

Uses

SB 204741 is a potent, selective SR-2B antagonist.

Definition

ChEBI: 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea is a member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It is a member of ureas, a member of indoles and a member of 1,2-thiazoles.

Biological Activity

Potent and selective 5-HT 2B receptor antagonist (pA 2 = 7.95). Displays ≥ 135-fold selectivity over 5-HT 2C (pK i = 5.82), 5-HT 2A (pK i < 5.2), 5-HT 1A , 1D , 1E , 5-HT 3 and 5-HT 4 receptors.

storage

Room temperature

SB 204741 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SB 204741 manufacturers

Career Henan Chemica Co
Product
SB 204741 152239-46-8
Price
US $1.00/KG
Min. Order
1KG
Purity
MIn98%HPLC/LC
Supply Ability
100KGS
Release date
2020-10-29

152239-46-8, SB 204741Related Search:


  • SB 204741
  • N-(1-METHYL-1H-5-INDOLYL)-N'-(3-METHYL-5-ISOTHIAZOLYL)UREA
  • N-(1-METHYL-1H-INDOLYL-5-YL)-N''-(3-METHYL-5-ISOTHIAZOLYL)UREA
  • 1-(1-Methyl-1H-indol-5-yl)-3-(3-Methylisothiazol-5-yl)urea
  • 3-(3-METHYL-1,2-THIAZOL-5-YL)-1-(1-METHYLINDOL-5-YL)UREA
  • 1-(1-methyl-5-indolyl)-3-(3-methyl-5-isothiazolyl)urea
  • Urea, N-(1-methyl-1H-indol-5-yl)-N'-(3-methyl-5-isothiazolyl)-
  • human,inhibit,SB204741,5-HT Receptor,Inhibitor,remodeling,Serotonin Receptor,selective,SB 204741,isoproterenol-induced,affinity,SB-204741,5-hydroxytryptamine Receptor,myocardial
  • 152239-46-8
  • API