ChemicalBook > CAS DataBase List > 6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER

6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER

Product Name: 6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER
CAS No.: 150810-68-7
Chemical Name: 6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER
Synonyms: CS-2126;5-TAMRASE;5-TAMRA,SE, >95%;5-TAMRA-SEor5-TAMRA-NHS;5-TAMRA SE (Orange Red);5-TAMRA Azide (CCT-1245);5-TAMRA-SE, 10 mM in DMSO;5-TAMRA N-Succinimidyl Ester;5-TAMRA,SE [5-Carboxytetramethylrhodamine, SE];5-Carboxytetramethylrhodamine succinimidyl ester
CBNumber: CB1207615
Molecular Formula: C29H25N3O7
Formula Weight: 527.53
MOL File: 150810-68-7.mol

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6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER Property

storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMF: soluble
form: A solid
color: Pale purple to purple
Appearance: Dark red amorphous solid
InChIKey: VWFRSNKRTNUMET-UHFFFAOYSA-N
SMILES: C(C1C=C(C(=O)ON2C(CCC2=O)=O)C=CC=1C1=C2C=CC(N(C)C)=CC2=[O+]C2C=C(N(C)C)C=CC1=2)(=O)[O-]

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Safety

WGK Germany: 3
HS Code: 32049010

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 53048
Product name: 5-Carboxy-tetramethylrhodamine N-succinimidyl ester
Purity: BioReagent,suitableforfluorescence
Packaging: 1mg
Price: $169
Updated: 2025/07/31

Sigma-Aldrich

Product number: 53048
Product name: 5-Carboxy-tetramethylrhodamine N-succinimidyl ester
Purity: BioReagent,suitableforfluorescence
Packaging: 5mg
Price: $573
Updated: 2025/07/31

TCI Chemical

Product number: T2808
Product name: 5-TAMRA SE
Packaging: 5MG
Price: $167
Updated: 2025/07/31

TCI Chemical

Product number: T2808
Product name: 5-TAMRA SE
Packaging: 25MG
Price: $499
Updated: 2025/07/31

Cayman Chemical

Product number: 28509
Product name: 5-Carboxytetramethylrhodamine succinimidyl ester
Packaging: 5mg
Price: $116
Updated: 2024/03/01

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6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER Chemical Properties,Usage,Production

Description

5-Carboxytetramethylrhodamine succinimidyl ester (5-TAMRA-SE) is an amine-reactive fluorescent probe. It has been used in double site-directed peptide modification to label proteinase substrates for use in FRET assays. It quenches lucifer yellow CH fluorescence by greater than 90% in uncleaved proteinase substrates, which allows for the detection of enzyme-cleaved substrates by an increase in fluorescence intensity. It has also been used in the synthesis of fluorescent derivatives of a variety of compounds, including the antibiotic ampicillin , nucleotide diphosphate uridine-5’-diphosphate (UDP; ), and the progesterone receptor antagonist RU486 (mifepristone; ). 5-TAMRA-SE displays excitation maxima ranging from 540 to 560 nm and an emission maximum of 580 nm.

Uses

Amine-reactive form of 5-carboxytetramethylrhodamine single isomer.

Uses

Amine-Reactive Fluorescent Probe for labeling of DNA and RNA

storage

Store at -20°C

References

[1] KIERAN F. GEOGHEGAN. Site-directed double fluorescent tagging of human renin and collagenase (MMP-1) substrate peptides using the periodate oxidation of N-terminal serine. An apparently general strategy for provision of energy-transfer substrates for proteases[J]. Bioconjugate Chemistry Bioconjugate, 1993, 4 6: 537-544. DOI: 10.1021/bc00024a017
[2] ADAM B. SHAPIRO* Mark S Janelle Comita Prevoir. 5-Carboxytetramethylrhodamine-Ampicillin Fluorescence Anisotropy-Based Assay of Escherichia coli Penicillin-Binding Protein 2 Transpeptidase Inhibition[J]. ACS Infectious Diseases, 2019, 5 6: 863-872. DOI: 10.1021/acsinfecdis.8b00351
[3] JUN QI Pablo S Michelle Oppenheimer. Fluorescence Polarization Binding Assay for Aspergillus fumigatus Virulence Factor UDP-Galactopyranose Mutase.[J]. Enzyme Research, 2011, 2011: 513905. DOI: 10.4061/2011/513905
[4] ROY WEINSTAIN. Fluorescent Ligand for Human Progesterone Receptor Imaging in Live Cells[J]. Bioconjugate Chemistry Bioconjugate, 2013, 24 5: 766-771. DOI: 10.1021/bc3006418

Abs/Em Maxima

553/575 nm

Excitation / Emission Maximum

546 nm/580 nm

Extinction Coefficient

92,000

Microscopy Laser Line

532 nm or 555 nm

Flow Cytometry Laser Line

532 nm or 555 nm

Spectrally Similar Dyes

Alexa Fluor® 555, CF® 555, DyLight® 549

6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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150810-68-7, 6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTERRelated Search:

6-Carboxytetramethylrhodamine succinimidyl ester 5-Carboxyfluorescein N-succinimidyl ester 4',6-Diamidino-2-phenylindole dihydrochloride 5(6)-Carboxytetramethylrhodamine 6-Carboxyfluorescein 3',6'-Dihydroxy-6-isothiocyanatospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one 5(6)-Carboxyfluorescein Fluorescein isothiocyanate 5-Carboxytetramethylrhodamine 5-Carboxyfluorescein Fluorescein isothiocyanate isomer I 6-Carboxytetramethylrhodamine 5-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER 5-CARBOXYTETRAMETHYLRHODAMINE 6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER 5-ROX, SE 5-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER 6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER

6-CARBOXYTETRAMETHYLRHODAMINE N-HYDROXYSUCCINIMIDE ESTER

Xanthylium, 9-2-carboxy-4-(2,5-dioxo-1-pyrrolidinyl)oxycarbonylphenyl-3,6-bis(dimethylamino)-, inner salt

5-TAMRA, SE [5-Carboxytetramethylrhodamine, succinimidyl ester] *Single isomer*

5-TAMRA,SE, >95%

5-Carboxytetramethylrhodamine succinimidyl ester

5-TAMRASE

"4-Carboxytetramethylrhodamine N-succinimidyl ester"

5-TAMRA-SEor5-TAMRA-NHS

2-(3,6-Bis(dimethylamino)xanthylium-9-yl)-5-(((2,5-dioxopyrrolidin-1-yl)oxy)carbonyl)benzoate

5-TAMRA, SE [5-Carboxytetramethylrhodamine, succinimidyl ester] *CAS#: 150810-68-7*

5-TAMRA N-succinimidyl ester (5-Carboxy-tetramethylrhodamine N-succinimidyl ester)

CS-2126

2-[6-(Dimethylamino)-3-(dimethyliminio)-3H-xanthen-9-yl]-5-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]benzoate

5-TAMRA N-Succinimidyl Ester

2-[3-(dimethylamino)-6-dimethylazaniumylidenexanthen-9-yl]-5-(2,5-dioxopyrrolidin-1-yl)oxycarbonylbenzoate

5-TAMRA-SE, 10 mM in DMSO

5-TAMRA,SE [5-Carboxytetramethylrhodamine, SE]

5-Carboxy-tetramethylrhodamine <i>N</i>-succinimidyl ester

5-TAMRA Azide (CCT-1245)

5-Carboxytetramethylrhodamine succinimidyl ester HPLC Purity:95%min at 254nm detection

5-TAMRA SE (Orange Red)

150810-68-7

C29H15N307

Biochemicals and Reagents

BioChemical

Fluorescent Probes, Labels, Particles and Stains

Detection

FLUOROPHORES