1-Benzo[b]thiophen-3-yl-2-bromoethan-1-one

Product Name: 1-Benzo[b]thiophen-3-yl-2-bromoethan-1-one
CAS No.: 26167-45-3
Chemical Name: 1-Benzo[b]thiophen-3-yl-2-bromoethan-1-one
Synonyms: 3-(Bromoacetyl)benzothiophene;3-(Bromoacetyl)benzo[b]thiophene;3-(Bromoacetyl)benzo[b]thiophene97%;3-(Bromoacetyl)benzo[b]thiophene 97%;1-Benzothiophen-3-yl-2-bromoethan-1-one;Ethanone, 1-benzo[b]thien-3-yl-2-bromo-;1-(1-benzothiophen-3-yl)-2-bromoethanone;1-(Benzo[b]thiophen-3-yl)-2-broMoethanone;1-BENZO[B]THIOPHEN-3-YL-2-BROMOETHAN-1-ONE;1-(1-benzothiophen-3-yl)-2-broMoethan-1-one
CBNumber: CB1208364
Molecular Formula: C10H7BrOS
Formula Weight: 255.13
MOL File: 26167-45-3.mol

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1-Benzo[b]thiophen-3-yl-2-bromoethan-1-one Property

Melting point:: 138 °C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: crystalline solid
color: White
CAS DataBase Reference: 26167-45-3

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Safety

Hazard Codes: C
Risk Statements: 36/37/38-34
Safety Statements: 26-36/37/39-45-26/37/39
RIDADR: 3261
Hazard Note: Corrosive
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: B276743
Product name: 1-(Benzo[b]thiophen-3-yl)-2-bromoethanone
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR23175
Product name: 3-(Bromoacetyl)benzo[b]thiophene
Purity: 97%
Packaging: 250mg
Price: $51
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6H66-9-X4
Product name: 3-(Bromoacetyl)benzo[b]thiophene
Purity: 97%
Packaging: 250mg
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140874
Product name: 1-(Benzo[b]thiophen-3-yl)-2-bromoethanone
Packaging: 250mg
Price: $87.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140874
Product name: 1-(Benzo[b]thiophen-3-yl)-2-bromoethanone
Packaging: 500mg
Price: $150
Updated: 2021/12/16

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1-Benzo[b]thiophen-3-yl-2-bromoethan-1-one Chemical Properties,Usage,Production

Chemical Properties

Gray solid

Uses

1-(Benzo[b]thiophen-3-yl)-2-bromoethanone is one of the thiazole analogs of indomethacin as selective COX-2 inhibitors.

Synthesis

1128-05-8

26167-45-3

General procedure for the synthesis of 1-benzo[b]thiophen-3-yl-2-bromoethyl-1-one from 1-(benzo[b]thiophen-3-yl)ethanone: 1-(benzo[b]thiophen-3-yl)ethanone (21 mmol) was dissolved in a mixed solvent of ethyl acetate (50 ml) and chloroform (50 ml), followed by addition of copper(II) bromide (40.2 mmol). The reaction mixture was stirred under reflux conditions for 3 hours. After completion of the reaction, the resulting copper bromide precipitate was removed by filtration. The filtrate was washed sequentially with distilled water (20 ml x 3) to remove water-soluble impurities and then dried with anhydrous sodium sulfate overnight. After drying, the desiccant was removed by filtration and the residue was washed with a small amount of ethyl acetate. The solvent in the filtrate was evaporated by rotary evaporator to obtain the crude product. Finally, the crude product was purified by ethanol recrystallization to give a light yellow crystalline solid in about 75% yield.

References

[1] Patent: EP2311828, 2011, A1. Location in patent: Page/Page column 9
[2] Tetrahedron Asymmetry, 2008, vol. 19, # 16, p. 1959 - 1964
[3] Patent: WO2014/31784, 2014, A1. Location in patent: Paragraph 0548
[4] Journal of Chemical Research, Miniprint, 1994, # 5, p. 1042 - 1059
[5] Journal of Scientific and Industrial Research, 1955, vol. 14 B, p. 11

1-Benzo[b]thiophen-3-yl-2-bromoethan-1-one Preparation Products And Raw materials

Raw materials

Thianaphthene Tin tetrachloride Acetyl chloride Carbon tetrachloride Bromine Dichloromethane

Preparation Products

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1-Benzo[b]thiophen-3-yl-2-bromoethan-1-one Suppliers

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26167-45-3, 1-Benzo[b]thiophen-3-yl-2-bromoethan-1-oneRelated Search:

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26167-45-3

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