ChemicalBook > CAS DataBase List > LY 294002 HYDROCHLORIDE

LY 294002 HYDROCHLORIDE

Product Name
LY 294002 HYDROCHLORIDE
CAS No.
154447-36-6
Chemical Name
LY 294002 HYDROCHLORIDE
Synonyms
YX;CS-1859;SF 1101;LY240092;LY 294002;NSC 697286;LY294002HCl;LY294002/PI3K;LY 294002, 99+%;PI3K inhibitor kit
CBNumber
CB1242450
Molecular Formula
C19H17NO3
Formula Weight
307.34
MOL File
154447-36-6.mol
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LY 294002 HYDROCHLORIDE Property

Melting point:
183-185℃
Boiling point:
494.6±45.0 °C(Predicted)
Density 
1.266
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: >5 mg/mL
form 
solid
pka
0.55±0.20(Predicted)
color 
white to off-white
Water Solubility 
Soluble in DMSO at 5mg/ml. Insoluble in water
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey
CZQHHVNHHHRRDU-UHFFFAOYSA-N
CAS DataBase Reference
154447-36-6
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Safety

Safety Statements 
24-25
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H320Causes eye irritation

H336May cause drowsiness or dizziness

H361Suspected of damaging fertility or the unborn child

H370Causes damage to organs

H372Causes damage to organs through prolonged or repeated exposure

H402Harmful to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
440202
Product name
LY 294002
Packaging
5mg
Price
$216
Updated
2024/03/01
Sigma-Aldrich
Product number
440202
Product name
LY 294002
Packaging
10mg
Price
$303
Updated
2024/03/01
TCI Chemical
Product number
M2410
Product name
2-Morpholino-8-phenylchromone
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$243
Updated
2024/03/01
Alfa Aesar
Product number
J67289
Product name
LY 294002, 98%
Packaging
5mg
Price
$89.7
Updated
2023/06/20
Alfa Aesar
Product number
J67289
Product name
LY 294002, 98%
Packaging
10mg
Price
$117
Updated
2021/12/16
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LY 294002 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

Uses

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

Uses

A potent blocker of PI 3-kinase/Akt signaling.

Uses

LY294002 is a selective phosphatidylinositol 3-kinase (PI3K) inhibitor with a 2.7-fold greater potency than quercetin. LY294002 inhibits purified PI3K with an IC50 of 1.4 μM.

Uses

LY 294002 is a Phosphatidylinositol 3-kinase (PI3K) inhibitor which has shown to block the formation of tumor tissues in bone marrow cavity an abolish multiple myeloma (MM) induced osteoclast formation and osteolysis in SCID mice.

Definition

ChEBI: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.

Biological Activity

A highly selective inhibitor of phosphatidylinositol 3-kinase (IC 50 values are 0.31, 0.73, 1.06 and 6.60 μ M for PI3K β , PI3K α , PI3K δ and PI3K γ respectively). Inhibits proliferation and induces apoptosis in human colon cancer cells in vitro and in vivo .

target

p110α

References

1) Vlahos et al. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002); J. Biol. Chem., 269 5241

LY 294002 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 294002 HYDROCHLORIDE Suppliers

Americas 1 Australia 1 China 229 China Hong Kong 1 Europe 1 Germany 4 India 2 Japan 4 Switzerland 2 United Kingdom 10 United States 40 Global 295
Ascent Scientific
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4401179829988
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4402030 700 369
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Novachemistry
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44-20819178-90 02081917890
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(0)2080432064
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info@novachemistry.com
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Apollo Scientific Ltd.
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Fluorochem Ltd
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Fluorochem Ltd.
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solutions@vwr.com
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View Lastest Price from LY 294002 HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
LY 294002 HYDROCHLORIDE 154447-36-6
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

154447-36-6, LY 294002 HYDROCHLORIDERelated Search:

NAD+ Ribonucleic acid Acetylcholine 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2 (S)-3-fluoro-4-(4-((2-(3-fluorophenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide LY 88074 LY-364947 LY2409881 trihydrochloride LY 2784544 LY2584702 LY3214996 2-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)pyridin-2-yl)propan-2-ol Etalocib LY2228820 LY-2562175 LY2828360

  • LY 294002
  • LY 294002 HYDROCHLORIDE
  • 2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE
  • 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
  • 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE
  • 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
  • CS-1859
  • LY294002 (HCl Salt)
  • 2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ON
  • InSolution LY 294002 - CAS 154447-36-6 - Calbiochem
  • LY 294002 - CAS 154447-36-6 - Calbiochem
  • LY 294002, 99+%
  • LY294002HCl
  • 2-(4-morpholinyl)-8-phenyl-1(4h)-benzopyran-4-one hydrochloride
  • LY-294002;LY 294002;LY 294002 HYDROCHLORIDE;2-[4-MORPHOLINYL]-8-PHENYL-1[4H]-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE;2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE HYDROCHLORIDE;2-(4-MORPHOLINO)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE
  • 8-Phenyl-2-(morpholin-4-yl)chromen-4-one
  • 2-[4-Morpholinyl]-8-phenyl-1[4H]-benzopyran-4-on
  • NSC 697286
  • SF 1101
  • 2-Morpholino-8-phenyl-4H-chroMen-4-one
  • 2-Morpholino-8-phenylchroMone
  • 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY 294002
  • LY 294002 8-Phenyl-2-(morpholin-4-yl)chromen-4-one
  • LY294002 (HCI Salt)
  • LY240092
  • LY294002, NSC 697286
  • 2-Morpholino-8-phenyl-4-oxo-4H-1-benzopyran
  • InSolution? LY 294002
  • 2-(4-Morpholinyl)-8-phenyl-4H-chromen-4-on
  • PI3K inhibitor kit
  • NSC 697286; SF 1101; LY 294002; LY-294002
  • Morpholino phenylchromone
  • 2-Morpholino-8-phenylchromone&gt
  • 4H-1-Benzopyran-4-one, 2-(4-morpholinyl)-8-phenyl-
  • YX
  • LY294002/PI3K
  • LY 294002 HYDROCHLORIDE USP/EP/BP
  • LY 294002, Free Base
  • LY 294002 (DMSO solution)
  • 154447-36-6
  • C19H18ClNO3HCl
  • C19H17O3N
  • Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Kinase/Phosphatase Biology
  • Phosphatidylinositol 3-kinase (PI3K)
  • Serine/Threonine Kinase Inhibitors
  • PI3K/Akt Signaling
  • Inhibitors
  • Inhibitor
  • Anti-cancer&immunity
  • PI3K/Akt/mTOR
  • Akt
  • mTOR
  • PI3K
  • Cell Cycle Regulation