ChemicalBook > CAS DataBase List > 2-Amino-3-Difluoromethoxy-5-Bromopyridine

2-Amino-3-Difluoromethoxy-5-Bromopyridine

Product Name: 2-Amino-3-Difluoromethoxy-5-Bromopyridine
CAS No.: 947249-13-0
Chemical Name: 2-Amino-3-Difluoromethoxy-5-Bromopyridine
Synonyms: 5-Bromo-3-(difluoromethoxy);5-bromo-3-(difluoromethoxy)-2-Pyridinamine;5-Bromo-3-(difluoromethoxy)pyridin-2-amine;5-Bromo-3-(di?uoromethoxy)pyridi n-2-amine;5-bromo-3-(difluoromethoxy)pyridine-2-amine;2-Pyridinamine, 5-bromo-3-(difluoromethoxy)-;5-bromo-3-[(difluoromethyl)oxy]pyridin-2-amine
CBNumber: CB12489954
Molecular Formula: C6H5BrF2N2O
Formula Weight: 239.02
MOL File: 947249-13-0.mol

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2-Amino-3-Difluoromethoxy-5-Bromopyridine Property

Boiling point:: 248.9±35.0 °C(Predicted)
Density: 1.752
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.85±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: PC201383
Product name: 5-Bromo-3-(difluoromethoxy)pyridin-2-amine
Purity: 98%
Packaging: 250mg
Price: $72
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105825
Product name: 5-bromo-3-(difluoromethoxy)-2-pyridinamine
Packaging: 250mg
Price: $137.5
Updated: 2021/12/16

Apolloscientific

Product number: PC201383
Product name: 5-Bromo-3-(difluoromethoxy)pyridin-2-amine
Purity: 98%
Packaging: 1g
Price: $179
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB105825
Product name: 5-bromo-3-(difluoromethoxy)-2-pyridinamine
Packaging: 500mg
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0037612
Product name: 5-BROMO-3-(DIFLUOROMETHOXY)PYRIDIN-2-AMINE
Purity: 95.00%
Packaging: 250MG
Price: $228.9
Updated: 2021/12/16

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2-Amino-3-Difluoromethoxy-5-Bromopyridine Chemical Properties,Usage,Production

Uses

5-Bromo-3-(Difluoromethoxy)Pyridin-2-Amine is used in preparation of imidazo[1,2-a]pyridinyl derivatives and their use in the treatment of disease.

Synthesis

947249-14-1

947249-13-0

General procedure for the synthesis of 2-amino-3-(difluoromethoxy)-5-bromopyridine from 3-(difluoromethoxy)pyridin-2-amine: N-bromosuccinimide (2.61 g, 14.65 mmol) was slowly added to an acetonitrile solution (15 mL) of 3-(difluoromethoxy)pyridin-2-amine (2.3 g, 14.36 mmol) over a period of 3 min at 0 °C ) in acetonitrile. The reaction mixture was continued to be stirred at the same temperature for 20 minutes. Subsequently, the reaction solution was concentrated to dryness in vacuo and the resulting viscous material was diluted with water and extracted with ethyl acetate (3 x 60 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated again to dryness. The residue was purified by column chromatography (silica gel, 100-200 mesh, 20% hexane solution of ethyl acetate as eluent) to afford the target product 5-bromo-3-(difluoromethoxy)pyridin-2-amine (3.2 g, 93% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, DMSO-d6): δ 7.89 (s, 1H), 7.51 (s, 1H), 7.16 (t, J = 73.6 Hz, 1H), 6.34 (s, 2H).

References

[1] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 108; 109
[2] Patent: WO2015/91889, 2015, A1. Location in patent: Page/Page column 74, 75
[3] Patent: US2015/175619, 2015, A1. Location in patent: Paragraph 0221; 0222
[4] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 56
[5] Patent: US2013/210818, 2013, A1. Location in patent: Paragraph 0416

2-Amino-3-Difluoromethoxy-5-Bromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-3-Difluoromethoxy-5-Bromopyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: HEXAMETHYLPHOSPHOROUS TRIAMIDE 947249-13-0
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-27

Career Henan Chemical Co

Product: 5-Bromo-3-(difluoromethoxy)pyridin-2-amine 947249-13-0
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-01-12

947249-13-0, 2-Amino-3-Difluoromethoxy-5-BromopyridineRelated Search:

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5-Bromo-3-(difluoromethoxy)pyridin-2-amine

5-bromo-3-(difluoromethoxy)-2-Pyridinamine

5-Bromo-3-(difluoromethoxy)

5-bromo-3-(difluoromethoxy)pyridine-2-amine

2-Pyridinamine, 5-bromo-3-(difluoromethoxy)-

5-Bromo-3-(di?uoromethoxy)pyridi n-2-amine

5-bromo-3-[(difluoromethyl)oxy]pyridin-2-amine

947249-13-0

C6H5BrF2N2O