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2-Amino-3-Difluoromethoxy-5-Bromopyridine

Product Name
2-Amino-3-Difluoromethoxy-5-Bromopyridine
CAS No.
947249-13-0
Chemical Name
2-Amino-3-Difluoromethoxy-5-Bromopyridine
Synonyms
5-Bromo-3-(difluoromethoxy);5-bromo-3-(difluoromethoxy)-2-Pyridinamine;5-Bromo-3-(difluoromethoxy)pyridin-2-amine;5-Bromo-3-(di?uoromethoxy)pyridi n-2-amine;5-bromo-3-(difluoromethoxy)pyridine-2-amine;2-Pyridinamine, 5-bromo-3-(difluoromethoxy)-;5-bromo-3-[(difluoromethyl)oxy]pyridin-2-amine
CBNumber
CB12489954
Molecular Formula
C6H5BrF2N2O
Formula Weight
239.02
MOL File
947249-13-0.mol
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2-Amino-3-Difluoromethoxy-5-Bromopyridine Property

Boiling point:
248.9±35.0 °C(Predicted)
Density 
1.752
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
4.85±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC201383
Product name
5-Bromo-3-(difluoromethoxy)pyridin-2-amine
Purity
98%
Packaging
250mg
Price
$72
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105825
Product name
5-bromo-3-(difluoromethoxy)-2-pyridinamine
Packaging
250mg
Price
$137.5
Updated
2021/12/16
Apolloscientific
Product number
PC201383
Product name
5-Bromo-3-(difluoromethoxy)pyridin-2-amine
Purity
98%
Packaging
1g
Price
$179
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB105825
Product name
5-bromo-3-(difluoromethoxy)-2-pyridinamine
Packaging
500mg
Price
$210
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0037612
Product name
5-BROMO-3-(DIFLUOROMETHOXY)PYRIDIN-2-AMINE
Purity
95.00%
Packaging
250MG
Price
$228.9
Updated
2021/12/16
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2-Amino-3-Difluoromethoxy-5-Bromopyridine Chemical Properties,Usage,Production

Uses

5-Bromo-3-(Difluoromethoxy)Pyridin-2-Amine is used in preparation of imidazo[1,2-a]pyridinyl derivatives and their use in the treatment of disease.

Synthesis

947249-14-1

947249-13-0

General procedure for the synthesis of 2-amino-3-(difluoromethoxy)-5-bromopyridine from 3-(difluoromethoxy)pyridin-2-amine: N-bromosuccinimide (2.61 g, 14.65 mmol) was slowly added to an acetonitrile solution (15 mL) of 3-(difluoromethoxy)pyridin-2-amine (2.3 g, 14.36 mmol) over a period of 3 min at 0 °C ) in acetonitrile. The reaction mixture was continued to be stirred at the same temperature for 20 minutes. Subsequently, the reaction solution was concentrated to dryness in vacuo and the resulting viscous material was diluted with water and extracted with ethyl acetate (3 x 60 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated again to dryness. The residue was purified by column chromatography (silica gel, 100-200 mesh, 20% hexane solution of ethyl acetate as eluent) to afford the target product 5-bromo-3-(difluoromethoxy)pyridin-2-amine (3.2 g, 93% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, DMSO-d6): δ 7.89 (s, 1H), 7.51 (s, 1H), 7.16 (t, J = 73.6 Hz, 1H), 6.34 (s, 2H).

References

[1] Patent: WO2014/111496, 2014, A1. Location in patent: Page/Page column 108; 109
[2] Patent: WO2015/91889, 2015, A1. Location in patent: Page/Page column 74, 75
[3] Patent: US2015/175619, 2015, A1. Location in patent: Paragraph 0221; 0222
[4] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 56
[5] Patent: US2013/210818, 2013, A1. Location in patent: Paragraph 0416

2-Amino-3-Difluoromethoxy-5-Bromopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-3-Difluoromethoxy-5-Bromopyridine Suppliers

China 53 India 2 United Kingdom 2 United States 5 Global 62
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
SL Drugs and Pharmaceuticals Pvt. Ltd.
Tel
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Fax
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Email
enquiry@sldrugs.com
Country
India
ProdList
2683
Advantage
50
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View Lastest Price from 2-Amino-3-Difluoromethoxy-5-Bromopyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
HEXAMETHYLPHOSPHOROUS TRIAMIDE 947249-13-0
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-27
Career Henan Chemical Co
Product
5-Bromo-3-(difluoromethoxy)pyridin-2-amine 947249-13-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2020-01-12

947249-13-0, 2-Amino-3-Difluoromethoxy-5-BromopyridineRelated Search:

Methyl 5-bromo-3-(trifluoromethyl)-2-pyridinecarboxylate 5-bromo-2-pyridinecarboxylic acid ethyl ester 5-BROMO-3,4-DIHYDROQUINOLIN-2(1H)-ONE 5-BROMO-3-(BROMOMETHYL)PYRIDIN-2-AMINE HYDROBROMIDE 5-BROMO-3-CYANO-2-HYDROXYPYRIDINE 5-BROMO-3-METHYL-1H-PYRAZOLE 5-BROMO-3-FORMYLINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5-BROMO-3-CHLORO-1H-INDAZOLE 5-Bromo-3-cyanoindole 5-BroMo-3,3-diMethylindoline 5-Bromo-3-chlorophenylene-1,2-diamine, 5-Bromo-3-chloro-1,2-diaminobenzene 1H-Indole, 5-broMo-3-iodo- Methyl-5-bromo-2 pyrimidine carboxylate 5-BROMO-3-IODO-PYRIDIN-2-OL 5-BROMO-3-IODO-2-METHOXYPYRIDINE 5-Bromo-3-(trifluoromethyl)-2-pyridinecarbonitrile 5-Bromo-2-hydroxy-3-(trifluoromethyl)pyridine 5-BroMo-3,4-dihydroisoquinolin-1(2H)-one

  • 5-Bromo-3-(difluoromethoxy)pyridin-2-amine
  • 5-bromo-3-(difluoromethoxy)-2-Pyridinamine
  • 5-Bromo-3-(difluoromethoxy)
  • 5-bromo-3-(difluoromethoxy)pyridine-2-amine
  • 2-Pyridinamine, 5-bromo-3-(difluoromethoxy)-
  • 5-Bromo-3-(di?uoromethoxy)pyridi n-2-amine
  • 5-bromo-3-[(difluoromethyl)oxy]pyridin-2-amine
  • 947249-13-0
  • C6H5BrF2N2O