Brivanib alaninate
- Product Name
- Brivanib alaninate
- CAS No.
- 649735-63-7
- Chemical Name
- Brivanib alaninate
- Synonyms
- CS-362;Bms582664;Bms 582664;Neopterin-13C5;Unii-U2Y5ofn795;Brivanib alaninate;[14C]-Brivanib alaninate;Unii-U2Y5ofn795 USP/EP/BP;Brivanib alaninate BMS-540215;Brivanib alaninate(BMS-582664)
- CBNumber
- CB12497201
- Molecular Formula
- C22H24FN5O4
- Formula Weight
- 441.46
- MOL File
- 649735-63-7.mol
Brivanib alaninate Property
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥22.05 mg/mL in DMSO; insoluble in H2O; ≥10.03 mg/mL in EtOH
- form
- Yellow powder.
- pka
- 16.08±0.30(Predicted)
- color
- White to brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 26081
- Product name
- Brivanib Alaninate
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 26081
- Product name
- Brivanib Alaninate
- Packaging
- 50mg
- Price
- $926
- Updated
- 2024/03/01
- Product number
- 26081
- Product name
- Brivanib Alaninate
- Packaging
- 10mg
- Price
- $209
- Updated
- 2024/03/01
- Product number
- 26081
- Product name
- Brivanib Alaninate
- Packaging
- 25mg
- Price
- $492
- Updated
- 2024/03/01
- Product number
- B677640
- Product name
- BrivanibAlaninate
- Packaging
- 50mg
- Price
- $875
- Updated
- 2021/12/16
Brivanib alaninate Chemical Properties,Usage,Production
Uses
BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively.
Uses
A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor.
Definition
ChEBI: Brivanib alaninate is a carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a prodrug, an apoptosis inducer, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is a pyrrolotriazine, an aromatic ether, a fluoroindole, a diether, a carboxylic ester and a L-alanine derivative. It is functionally related to a brivanib.
target
VEGFR2
Brivanib alaninate Preparation Products And Raw materials
Raw materials
Preparation Products
Brivanib alaninate Suppliers
- Tel
- --
- Fax
- --
- info@trc-canada.com
- Country
- Canada
- ProdList
- 6038
- Advantage
- 71
View Lastest Price from Brivanib alaninate manufacturers
- Product
- Unii-U2Y5ofn795 649735-63-7
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 100kg; 1000kg
- Release date
- 2019-12-24