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Brivanib alaninate

Product Name
Brivanib alaninate
CAS No.
649735-63-7
Chemical Name
Brivanib alaninate
Synonyms
CS-362;Bms582664;Bms 582664;Neopterin-13C5;Unii-U2Y5ofn795;Brivanib alaninate;[14C]-Brivanib alaninate;Unii-U2Y5ofn795 USP/EP/BP;Brivanib alaninate BMS-540215;Brivanib alaninate(BMS-582664)
CBNumber
CB12497201
Molecular Formula
C22H24FN5O4
Formula Weight
441.46
MOL File
649735-63-7.mol
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Brivanib alaninate Property

Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥22.05 mg/mL in DMSO; insoluble in H2O; ≥10.03 mg/mL in EtOH
form 
Yellow powder.
pka
16.08±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26081
Product name
Brivanib Alaninate
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
26081
Product name
Brivanib Alaninate
Packaging
50mg
Price
$926
Updated
2024/03/01
Cayman Chemical
Product number
26081
Product name
Brivanib Alaninate
Packaging
10mg
Price
$209
Updated
2024/03/01
Cayman Chemical
Product number
26081
Product name
Brivanib Alaninate
Packaging
25mg
Price
$492
Updated
2024/03/01
TRC
Product number
B677640
Product name
BrivanibAlaninate
Packaging
50mg
Price
$875
Updated
2021/12/16
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Brivanib alaninate Chemical Properties,Usage,Production

Uses

BMS-582664 is an oral VEGFR/FGFR inhibitor for VEGFR2, Flk1, VEGFR1 and FGFR1 with IC50 of 25 nM, 89 nM, 380 nM and 148 nM, respectively.

Uses

A novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinase inhibitor.

Definition

ChEBI: Brivanib alaninate is a carboxylic ester resulting from the formal condensation of the carboxy group of L-alanine with the hydroxy group of brivanib. It is a prodrug of brivanib (BMS-540215), a potent oral dual inhibitor of VEGFR-2 and FGFR-1 (IC50 of 25 nM and 148 nM, respectively) and was in development for the treatment of hepatocellular and colon carcinomas. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, a prodrug, an apoptosis inducer, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is a pyrrolotriazine, an aromatic ether, a fluoroindole, a diether, a carboxylic ester and a L-alanine derivative. It is functionally related to a brivanib.

target

VEGFR2

Brivanib alaninate Preparation Products And Raw materials

Raw materials

Preparation Products

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Brivanib alaninate Suppliers

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View Lastest Price from Brivanib alaninate manufacturers

Career Henan Chemical Co
Product
Unii-U2Y5ofn795 649735-63-7
Price
US $0.10/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1kg; 100kg; 1000kg
Release date
2019-12-24

649735-63-7, Brivanib alaninateRelated Search:

3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol CCT 137690 Tariquidar (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione Torin 1 Telaprevir Avagacestat (BMS-708163) RO4929097 CUDC-101 AC480 (BMS-599626) AZD 1480 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol AZD-8055 (+)-JQ1 Nintedanib Linifanib (ABT-869) Trifluoromethyl

  • BMS-582664;BMS 582664;BMS582664
  • CS-362
  • L-Alanine (1R)-2-[[4-[(4-fluoro-2-Methyl-1H-indol-5-yloxy)]-5-Methyl-1H-pyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]isopropyl ester
  • (2R)-1-({4-[(4-fluoro-2-Methyl-1H-indol-5-yl)oxy]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-yl (2S)-2-aMinopropanoate
  • Brivanib alaninate BMS-540215
  • (1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester Brivanib alaninate (BMS-582664)
  • Bms 582664
  • Bms582664
  • Brivanib alaninate
  • L-Alanine, (1R)-2-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo(2,1-F)(1,2,4)triazin-6-yl)oxy)-1-methylethyl ester
  • Unii-U2Y5ofn795
  • (1R)-2-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)-1-methylethyl L-alanine ester
  • [14C]-Brivanib alaninate
  • (S)-(R)-1-((4-((5-Fluoro-2-methyl-1H-indol-6-yl)oxy)-5-methylpyrrolo-[2,1-f][1,2,4]triazin-6-y
  • Brivanib alaninate(BMS-582664)
  • Unii-U2Y5ofn795 USP/EP/BP
  • (R)-(S)-1-((4-((4-Fluoro-2-methyl-1H-indol-5-yl)oxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-yl 2-aminopropanoate
  • Neopterin-13C5
  • 649735-63-7
  • C22H24FN5O4
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