4-(Trifluoromethyl)benzylamine

Product Name: 4-(Trifluoromethyl)benzylamine
CAS No.: 3300-51-4
Chemical Name: 4-(Trifluoromethyl)benzylamine
Synonyms: PTF-BYM;p-CF3-benzylamine;4-(Trifluoromethy;RARECHEM AL BW 0030;4-triMethylbenzylaMine;4-AMINOMETHYLBENZOTRIFLUORIDE;-(Trifluoromethyl)benzylamine;P-(TRIFLUOROMETHYL)BENZYLAMINE;4-(TRIFLUOROMETHYL)BENZYLAMINE;4-(three fluoroMethyl)benzyl aMine
CBNumber: CB1251340
Molecular Formula: C8H8F3N
Formula Weight: 175.15
MOL File: 3300-51-4.mol

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4-(Trifluoromethyl)benzylamine Property

Melting point:: 43 °C
Boiling point:: 79-82 °C (15 mmHg)
Density: 1.229 g/mL at 25 °C (lit.)
refractive index: n20/D 1.464(lit.)
Flash point:: 167 °F
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 8.60±0.10(Predicted)
form: Liquid
Specific Gravity: 1.229
color: Clear colorless to light yellow
Sensitive: Air Sensitive
BRN: 2640698
InChI: InChI=1S/C8H8F3N/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-4H,5,12H2
InChIKey: PRDBLLIPPDOICK-UHFFFAOYSA-N
SMILES: C1(CN)=CC=C(C(F)(F)F)C=C1
CAS DataBase Reference: 3300-51-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38-34
Safety Statements: 26-36-45-36/37/39
RIDADR: 2735
WGK Germany: 3
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: III
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 263508
Product name: 4-(Trifluoromethyl)benzylamine
Purity: 97%
Packaging: 1g
Price: $39.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 263508
Product name: 4-(Trifluoromethyl)benzylamine
Purity: 97%
Packaging: 10g
Price: $195.7
Updated: 2025/07/31

TCI Chemical

Product number: T1508
Product name: 4-(Trifluoromethyl)benzylamine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: T1508
Product name: 4-(Trifluoromethyl)benzylamine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $177
Updated: 2025/07/31

TRC

Product number: T899035
Product name: 4-(Trifluoromethyl)benzylamine
Packaging: 5g
Price: $65
Updated: 2021/12/16

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4-(Trifluoromethyl)benzylamine Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow liquid

Uses

4-(Trifluoromethyl)benzylamine has been used in the synthesis of 3-[(2,4-dioxothiazolidin-5-yl)methyl]benzamide derivatives.

Synthesis

16939-49-4

3300-51-4

General procedure for the synthesis of 4-(trifluoromethyl)benzylamine from the compound (CAS:16939-49-4): 5.00 g (26.4 mmol) of 4-trifluoromethylbenzaldehyde oxime was dissolved in methanol, followed by the addition of 4.0 g (109.7 mmol) of hydrogen chloride gas and 252 mg of the same catalyst as in Example 1, and the reaction was carried out with continuous stirring for 3 hours. The reaction was carried out at 10 atm hydrogen pressure and room temperature (about 25°C). Upon completion of the reaction, the catalyst was removed and ether was added to the reaction mixture and neutralized with aqueous sodium hydroxide. Analysis of the separated ether layer by gas chromatography confirmed the formation of 4-trifluoromethylbenzylamine in 93.6% yield.

References

[1] Patent: US6331649, 2001, B1
[2] Patent: WO2009/62949, 2009, A1. Location in patent: Page/Page column 10-11

4-(Trifluoromethyl)benzylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(Trifluoromethyl)benzylamine Suppliers

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View Lastest Price from 4-(Trifluoromethyl)benzylamine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(Trifluoromethyl)benzylamine 3300-51-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-09

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(Trifluoromethyl)benzylamine 3300-51-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-(Trifluoromethyl)benzylamine 3300-51-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

3300-51-4, 4-(Trifluoromethyl)benzylamineRelated Search:

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RARECHEM AL BW 0030

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P-(TRIFLUOROMETHYL)BENZYLAMINE

ALPHA-AMINO-ALPHA',ALPHA',ALPHA'-TRIFLUORO-P-XYLENE

4-AMINOMETHYLBENZOTRIFLUORIDE

4-(TRIFLUOROMETHYL)BENZYLAMINE

1-[4-(TRIFLUOROMETHYL)PHENYL]METHANAMINE

4-(Trifluoromethyl)benzylamine, 97+%

[4-(trifluoromethyl)phenyl]methanamine

4-(Trifluoromethyl)benzylamine 97%

4-(Trifluoromethy

-(Trifluoromethyl)benzylamine

3300-51-4

Organic Building Blocks

Nitrogen Compounds

AMINE

Building Blocks

Amines

C8

Amines

C8

Nitrogen Compounds

Amine

Fluorine series

Anilines, Aromatic Amines and Nitro Compounds