ChemicalBook > CAS DataBase List > 2-Fluoro-4-nitrobenzoic acid

2-Fluoro-4-nitrobenzoic acid

Product Name
2-Fluoro-4-nitrobenzoic acid
CAS No.
403-24-7
Chemical Name
2-Fluoro-4-nitrobenzoic acid
Synonyms
NSC 190361;BUTTPARK 32\01-74;SALOR-INT L446572-1EA;Enzalutamide Impurity 25;2-Fluor-4-nitrobenzoic acid;2-Fluoro-4-nitrobenzotc acid;2-FLUORO-4-NITROBENZOIC ACID;2-chloro-4-nitrobenzoice acid;4-Carboxy-3-fluoronitrobenzene;Benzoicacid, 2-fluoro-4-nitro-
CBNumber
CB1262658
Molecular Formula
C7H4FNO4
Formula Weight
185.11
MOL File
403-24-7.mol
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2-Fluoro-4-nitrobenzoic acid Property

Melting point:
170 °C
Boiling point:
352.5±27.0 °C(Predicted)
Density 
1.568±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
2.37±0.13(Predicted)
color 
White to Light yellow
BRN 
2582091
InChI
InChI=1S/C7H4FNO4/c8-6-3-4(9(12)13)1-2-5(6)7(10)11/h1-3H,(H,10,11)
InChIKey
MMWFMFZFCKADEL-UHFFFAOYSA-N
SMILES
C(O)(=O)C1=CC=C([N+]([O-])=O)C=C1F
CAS DataBase Reference
403-24-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-37/39-36/37/39-22
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L446572
Product name
2-FLUORO-4-NITROBENZOIC ACID
Purity
Aldrich
Packaging
250mg
Price
$29.8
Updated
2024/03/01
TCI Chemical
Product number
F0797
Product name
2-Fluoro-4-nitrobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$66
Updated
2024/03/01
TCI Chemical
Product number
F0797
Product name
2-Fluoro-4-nitrobenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$196
Updated
2024/03/01
Alfa Aesar
Product number
L19770
Product name
2-Fluoro-4-nitrobenzoic acid, 98%
Packaging
1g
Price
$81.65
Updated
2024/03/01
Alfa Aesar
Product number
L19770
Product name
2-Fluoro-4-nitrobenzoic acid, 98%
Packaging
5g
Price
$285.65
Updated
2024/03/01
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2-Fluoro-4-nitrobenzoic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Synthesis

A mixture of 2-fluoro4-nitrotoluene (31.1 g, 0.2 mol), tetrabutylammonium bromide (3.2 g,0.01 mol), 1.0 L of 1N NaOH, and KMnO4 (20.0 g) was stirred at room temperature. After 10 min, the resulting mixture was heated to 95 °Cwith stirring. Additional 30.0 g portions of KMnO 4 were added after 2 h and 3 h. After stirring at 95 °C for an additional 10 h, the reaction mixture was cooled to room temperature and filtered through Celite to remove MnO2. The filtrate was acidified to pH 2 by adding concentrated hydrochloric acid. An off-white precipitate formed that was collected by vacuum filtration. The crude solid was dissolved in 300 mL of 1N aqueous NaOH, acidified to pH 2 using concentrated hydrochloric acid, and the mixture extracted with CH 2 Cl 2 (3 × 200 mL). The combined CH2 Cl 2extracts were washed with 0.1 N aqueous HCl (2 × 100 mL), dried over anhydrous Na2SO4, and concentrated in vacuo to afford 27.3 g (73.7%)of 2-fluoro-4-nitrobenzoic acid as a white crystalline solid, m.p. 174.5–176.0 °C (lit 7. m.p. 176–177 °C)[1].

References

[1] Defeng Xu, Zhiling Zhu, Xing Xu. “A Convenient Synthesis of 4-amino-2-fluoro-N-methyl-benzamide.” Journal of Chemical Research-s 17 1 (2013): 615–616.

2-Fluoro-4-nitrobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-nitrobenzoic acid Suppliers

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View Lastest Price from 2-Fluoro-4-nitrobenzoic acid manufacturers

Watson Biotechnology Co.,Ltd
Product
2-Fluoro-4-nitrobenzoic acid 403-24-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20MT
Release date
2024-08-07
Hangzhou ICH Biofarm Co., Ltd
Product
2-Fluoro-4-nitrobenzoic acid 403-24-7
Price
US $0.00-0.00/kg
Min. Order
0.1kg
Purity
99.0%min
Supply Ability
200kg
Release date
2023-06-09
Honest Joy Holdings Limited
Product
2-Fluoro-4 nitrobenzoic acid 403-24-7
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
100 tons
Release date
2022-02-21

403-24-7, 2-Fluoro-4-nitrobenzoic acidRelated Search:

4-Nitrobenzoic acid 1-Fluoro-2-nitrobenzene 2-Fluoro-4-methylbenzoic acid 3-Nitrobenzoic acid 2-Fluoro-4-nitrophenol 4-Fluoronitrobenzene 2-Fluoro-4-nitrobenzaldehyde METHYL 2-FLUORO-4-NITROBENZENECARBOXYLATE 4-Bromo-2-fluoro-N-methylbenzamide 4-BROMO-2-FLUOROBENZAMIDE 4-amino-2-fluoro-N-methylbenzamide 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- Enzalutamide Impurity 7 Benzoic acid, 4-isothiocyanato-2-(trifluoromethyl)- 2-FLUORO-N-METHYL-4-NITROBENZAMIDE 4-Amino-2-(trifluoromethyl)benzamide 4-NITRO-2-(TRIFLUOROMETHYL)BENZONITRILE 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile

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  • C7H3FNO4
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • intermediate
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  • Phenyls & Phenyl-Het
  • Benzoic acid
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