2-Fluoro-4-nitrobenzoic acid
- Product Name
- 2-Fluoro-4-nitrobenzoic acid
- CAS No.
- 403-24-7
- Chemical Name
- 2-Fluoro-4-nitrobenzoic acid
- Synonyms
- NSC 190361;BUTTPARK 32\01-74;SALOR-INT L446572-1EA;Enzalutamide Impurity 25;2-Fluor-4-nitrobenzoic acid;2-Fluoro-4-nitrobenzotc acid;2-FLUORO-4-NITROBENZOIC ACID;2-chloro-4-nitrobenzoice acid;4-Carboxy-3-fluoronitrobenzene;Benzoicacid, 2-fluoro-4-nitro-
- CBNumber
- CB1262658
- Molecular Formula
- C7H4FNO4
- Formula Weight
- 185.11
- MOL File
- 403-24-7.mol
2-Fluoro-4-nitrobenzoic acid Property
- Melting point:
- 170 °C
- Boiling point:
- 352.5±27.0 °C(Predicted)
- Density
- 1.568±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2.37±0.13(Predicted)
- color
- White to Light yellow
- BRN
- 2582091
- InChI
- InChI=1S/C7H4FNO4/c8-6-3-4(9(12)13)1-2-5(6)7(10)11/h1-3H,(H,10,11)
- InChIKey
- MMWFMFZFCKADEL-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C([N+]([O-])=O)C=C1F
- CAS DataBase Reference
- 403-24-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-37/39-36/37/39-22
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- L446572
- Product name
- 2-FLUORO-4-NITROBENZOIC ACID
- Purity
- Aldrich
- Packaging
- 250mg
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- F0797
- Product name
- 2-Fluoro-4-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $66
- Updated
- 2024/03/01
- Product number
- F0797
- Product name
- 2-Fluoro-4-nitrobenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $196
- Updated
- 2024/03/01
- Product number
- L19770
- Product name
- 2-Fluoro-4-nitrobenzoic acid, 98%
- Packaging
- 1g
- Price
- $81.65
- Updated
- 2024/03/01
- Product number
- L19770
- Product name
- 2-Fluoro-4-nitrobenzoic acid, 98%
- Packaging
- 5g
- Price
- $285.65
- Updated
- 2024/03/01
2-Fluoro-4-nitrobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Synthesis
A mixture of 2-fluoro4-nitrotoluene (31.1 g, 0.2 mol), tetrabutylammonium bromide (3.2 g,0.01 mol), 1.0 L of 1N NaOH, and KMnO4 (20.0 g) was stirred at room temperature. After 10 min, the resulting mixture was heated to 95 °Cwith stirring. Additional 30.0 g portions of KMnO 4 were added after 2 h and 3 h. After stirring at 95 °C for an additional 10 h, the reaction mixture was cooled to room temperature and filtered through Celite to remove MnO2. The filtrate was acidified to pH 2 by adding concentrated hydrochloric acid. An off-white precipitate formed that was collected by vacuum filtration. The crude solid was dissolved in 300 mL of 1N aqueous NaOH, acidified to pH 2 using concentrated hydrochloric acid, and the mixture extracted with CH 2 Cl 2 (3 × 200 mL). The combined CH2 Cl 2extracts were washed with 0.1 N aqueous HCl (2 × 100 mL), dried over anhydrous Na2SO4, and concentrated in vacuo to afford 27.3 g (73.7%)of 2-fluoro-4-nitrobenzoic acid as a white crystalline solid, m.p. 174.5–176.0 °C (lit 7. m.p. 176–177 °C)[1].
References
[1] Defeng Xu, Zhiling Zhu, Xing Xu. “A Convenient Synthesis of 4-amino-2-fluoro-N-methyl-benzamide.” Journal of Chemical Research-s 17 1 (2013): 615–616.
2-Fluoro-4-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-nitrobenzoic acid manufacturers
- Product
- 2-Fluoro-4-nitrobenzoic acid 403-24-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20MT
- Release date
- 2024-08-07
- Product
- 2-Fluoro-4-nitrobenzoic acid 403-24-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.1kg
- Purity
- 99.0%min
- Supply Ability
- 200kg
- Release date
- 2023-06-09
- Product
- 2-Fluoro-4 nitrobenzoic acid 403-24-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 100 tons
- Release date
- 2022-02-21