(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran

Physical Form Uses

Product Name: (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
CAS No.: 915095-94-2
Chemical Name: (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran
Synonyms: EMpagliflozin iMpurity C;(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene;]phenoxy}oxoL;oro-5-iodophenyL;(3S)-3-{4-[(2-chL;Englitin Impurity 28;Empagliflozin Impurity 110;Empagliflozin Intermediate1;(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc;1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene
CBNumber: CB12657939
Molecular Formula: C17H16ClIO2
Formula Weight: 414.67
MOL File: 915095-94-2.mol

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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Property

Boiling point:: 476.0±45.0 °C(Predicted)
Density: 1.578±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C(protect from light)
solubility: DMSO, Methanol (Slightly, Sonicated)
form: Solid
color: White to Off-White
InChI: InChI=1S/C17H16ClIO2/c18-17-6-3-14(19)10-13(17)9-12-1-4-15(5-2-12)21-16-7-8-20-11-16/h1-6,10,16H,7-9,11H2/t16-/m0/s1
InChIKey: YLUHNGIWRCCQMQ-INIZCTEOSA-N
SMILES: O1CC[C@H](OC2=CC=C(CC3=CC(I)=CC=C3Cl)C=C2)C1
CAS DataBase Reference: 915095-94-2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 9598AF
Product name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging: 1g
Price: $39
Updated: 2021/12/16

AK Scientific

Product number: J95043
Product name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging: 5g
Price: $88
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H10-M-S0
Product name: (3S)-3-{4-[(2-Chloro-5-iodophenyl)methyl]phenoxy}oxolane
Purity: 97.0%
Packaging: 250mg
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: 9598AF
Product name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging: 5g
Price: $118
Updated: 2021/12/16

AK Scientific

Product number: 9598AF
Product name: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan
Packaging: 10g
Price: $189
Updated: 2021/12/16

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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Chemical Properties,Usage,Production

Physical Form

Solid

Uses

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydrofuran(915095-94-2) can be used as reactant/reagent in preparation of C-?aryl D-?glurofuranoside compounds useful as reference compounds in the quality control of gliflozin type medicine.

Description

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran is a pharmaceutical intermediate compound that is used in the preparation of empagliflozin. Empagliflozin is an inhibitor of sodium-glucose co-transporter protein-2 (SGLT2), which is used in the treatment of type 2 diabetes.

Preparation

0.5 mol of (S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone and 0.6 mol of aluminum chloride were added to 2 mol of methanol at a temperature of 20° C, and then 0.6 mol of triethylsilane was added to the mixed solution. The mixture was stirred at 25° C for 1 h.The conversion is determined by HPLC analysis. After the reaction is complete, it is extracted and distilled under reduced pressure.Finally, (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan (also known as (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran) was obtained through purification.

(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran Suppliers

Canada 1 China 354 Germany 1 India 17 United Kingdom 1 United States 7 Global 381

Aladdin Scientific

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Eastar Chemical Corp

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Aceschem Inc.

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Synthonix Inc

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SynQuest Laboratories, Inc.

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Matrix Scientific

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View Lastest Price from (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran manufacturers

Sinoway Industrial co., ltd.

Product: Empagliflozin Intermediate 915095-94-2
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2024-07-08

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Empagliflozin Intermediate 915095-94-2
Price: US $0.00-0.00/g
Min. Order: 10000g
Purity: 99.0%min. HPLC
Supply Ability: 1000kg
Release date: 2024-09-12

Nanjing Fred Technology Co., Ltd

Product: (3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan 915095-94-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-03

915095-94-2, (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuranRelated Search:

(S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S,4R)-4-(4-Fluorophenyl)-3-hydroxymethyl-1-methylpiperidine Thiazole Copper(II) chloride dihydrate Tetrahydrofuran Dimethyl fumarate 1-Propanol Brexpiprazole Intermediate 1 (R)-3-(p-toluenesulfonyl) oxytetrahydrofuran Empagliflozin (S)-(+)-3-Hydroxytetrahydrofuran 4-(5-broMo-2-chlorobenzyl)phenol (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(S)-3-(4-(2-chloro-5-iodobenzyl)phenoxy)-tetrahydrofuran

(S)-3-(4-(2-chloro-5-fluorobenzyl)phenoxy)-tetrahydrofuran

EMpagliflozin iMpurity C

(S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene

(3S)-3-{4-[(2-chloro-5-iodophenyl)methyl]phenoxy}oxolane

(3S)-3-[4-(2-chloro-5-iodobenzyl)-phenoxy]-tetrahydrofuran

Furan, 3-[4-[(2-chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-, (3S)-

Empagliflozin Intermediate1

3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(3S-3-(4)Chloro-5-Iodophenyl)Methyl)Phenoxy)Tetrahydro-Furan

1-chloro-2-(4-(cyclopentyloxy)benzyl)-4-iodobenzene

Englitin Impurity 28

(3S)-3-{4-[(2-chL

]phenoxy}oxoL

oro-5-iodophenyL

(3S)-3-[4-[(2-CHLORO-5-IODOPHENYL)METHYL]PHENOXY]TETRAHYDRO-FURAN 915095-94-2

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan(For export only)

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan ISO 9001：2015 REACH

Empagliflozin Impurity 110

(3S)-3-[4-[(5-Iodo-2- Chlorophenyl) Methyl] Phenoxy] Tetrahydrofuran

(3S)-3-[4-[(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-...

Empagliflozin Intermediate/ (3S)-3-[4-[(2-Chloro-5-Iodophenyl)Methyl]Phenoxy]Tetrahydro-Furan

(3S)-3-[4-4(2-Chloro-5-iodophenyl)methyl]phenoxy]tetrahydro-furan

(3S)-3-[4-[(2-Chloro-5-iodophenyl) methyl] phenc

915095-94-2

C17H16ClIO2

Empagliflozin

Empagliflozin Intermediate

915095-94-2