P-5091

Product Name: P-5091
CAS No.: 882257-11-6
Chemical Name: P-5091
Synonyms: P5091;CS-726;P 5091;P-5091;P005091;P 005091;P-005091;P5091, >=98%;P005091(P5091);P5091 (P005091)
CBNumber: CB12668070
Molecular Formula: C12H7Cl2NO3S2
Formula Weight: 348.22
MOL File: 882257-11-6.mol

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P-5091 Property

Boiling point:: 452.4±45.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
color: light yellow to dark yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0770
Product name: P5091
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0770
Product name: P5091
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $435
Updated: 2024/03/01

Cayman Chemical

Product number: 15224
Product name: P005091
Purity: ≥98%
Packaging: 5mg
Price: $66
Updated: 2024/03/01

Cayman Chemical

Product number: 15224
Product name: P005091
Purity: ≥98%
Packaging: 10mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 15224
Product name: P005091
Purity: ≥98%
Packaging: 25mg
Price: $228
Updated: 2024/03/01

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P-5091 Chemical Properties,Usage,Production

Description

P5091 (882257-11-6) is a selective inhibitor of the ubiquitin-specific protease USP7 ( IC50=4.2 μM).1,2 Induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.1?P5091 displays antiangiogenic activity in vivo.2?Cell permeable

Uses

P005091 is a selective dual inhibitor of the cancer-related deubiquitylating proteases USP7 and USP47.

Uses

P5091 has been used:

as a ubiquitin specific peptidase 47 (USP47) inhibitor in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay to evaluate the cellular viability of MCF-10A cells
as a USP7 inhibitor to study the regulatory role for USP7 on inflammasome activation
as USP7 inhibitor in drug susceptibility assays to study its effect on bone marrow?resident tumor cells (BMRTCs)/ circulating tumor cells (CTCs)

Biochem/physiol Actions

P5091 plays an important role in ovarian cancer, as it can prevent the growth of cells and can promote necrosis and apoptosis.

References

1) Chauhan et al. (2012), A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance; Cancer Cell, 22 345 2) Weinstock et al. (2012), Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47; ACS Med. Chem. Lett., 3 789

P-5091 Preparation Products And Raw materials

Raw materials

Preparation Products

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P-5091 Suppliers

Canada 1 China 70 India 1 United Kingdom 1 United States 19 Global 92

MedChemexpress LLC

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Aladdin Scientific

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TargetMol Chemicals Inc.

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Selleck Chemicals LLC

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View Lastest Price from P-5091 manufacturers

Career Henan Chemica Co

Product: P-5091 882257-11-6
Price: US $0.01/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1kg; 5kg; 10kg
Release date: 2020-10-27

882257-11-6, P-5091Related Search:

AAL-993 NVP-BEZ 235 Apigenin INDIRUBIN-3'-MONOXIME Bortezomib PR-619 Degrasyn (WP1130) 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone MG-132 P 22077

1-[5-(2,3-dichlorophenyl)sulfanyl-4-nitro-2-thienyl]ethanone

P5091, >=98%

CS-726

P5091; P-005091; P 005091; P 5091; P-5091

1-[5-(2,3-Dichloro-phenylsulfanyl)-4-nitro-thiophen-2-yl]-ethanone

Ethanone, 1-[5-[(2,3-dichlorophenyl)thio]-4-nitro-2-thienyl]-

1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]-ethanone P005091

P005091(P5091)

P 005091

P 5091

P005091

P-005091

P5091

P-5091

1-(5-(2,3-dichlorophenylthio)-4-nitrothiophen-2-yl)ethanone

P5091 (P005091)

1-[5-[(2,3-Dichlorophenyl)thio]-4-n-itro-2-thienyl]ethanone

P-5091 USP/EP/BP

1-(5-((2,3-Dichlorophenyl)thio)-4-nitrothiophen-2-yl)ethan-1-one

882257-11-6

C12H7Cl2NO3S2

Inhibitors