3-Cyano-2-fluoropyridine
- Product Name
- 3-Cyano-2-fluoropyridine
- CAS No.
- 3939-13-7
- Chemical Name
- 3-Cyano-2-fluoropyridine
- Synonyms
- 3-Cyano-2-fluoropyri;2-Fluoronicotinonitrile;2-Fluoro-3-cyanopridine;3-CYANO-2-FLUOROPYRIDINE;4-Fluoro-nicotinonitrile;3-Fluoro-4-cyanopyridine;3-Cyano-4-fluoropyridine;2-FLUORO-3-CYANOPYRIDINE;3-Cyano-2-fluoropyridine,98%;3-Cyano-2-fluoropyridine >
- CBNumber
- CB1267077
- Molecular Formula
- C6H3FN2
- Formula Weight
- 122.1
- MOL File
- 3939-13-7.mol
3-Cyano-2-fluoropyridine Property
- Melting point:
- 27-30°C
- Boiling point:
- 214.6±20.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- Flash point:
- 98℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder to lump
- pka
- -3.88±0.10(Predicted)
- color
- White to Dark green
- BRN
- 386567
- InChI
- InChI=1S/C6H3FN2/c7-6-5(4-8)2-1-3-9-6/h1-3H
- InChIKey
- USIDQCCXMGJOJM-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=CC=C1C#N
- CAS DataBase Reference
- 3939-13-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-5-36/38-22
- Safety Statements
- 26-36/37/39-36-24/25-23-3
- RIDADR
- 3276
- WGK Germany
- 3
- Hazard Note
- Harmful/Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 736058
- Product name
- 2-Fluoropyridine-3-carbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $24
- Updated
- 2023/06/20
- Product number
- 736058
- Product name
- 2-Fluoropyridine-3-carbonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $84.3
- Updated
- 2023/06/20
- Product number
- C2538
- Product name
- 3-Cyano-2-fluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $50
- Updated
- 2025/07/31
- Product number
- C2538
- Product name
- 3-Cyano-2-fluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $187
- Updated
- 2025/07/31
- Product number
- F593693
- Product name
- 2-Fluoronicotinonitrile
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
3-Cyano-2-fluoropyridine Chemical Properties,Usage,Production
Uses
3-Cyano-2-fluoropyridine have been successfully used in preparation of compounds with diverse spectrum of biological activity. Other 3-cyano-2-fluoropyridine can potentially be used as promising agents for the positron emission tomography (PET). Additionally, it has previously been demonstrated that 3-cyanopyridines can be transformed into -amides, -carboxylic acids, and -esters.
Synthesis
6602-54-6
3939-13-7
General method: 2-chloro-3-cyanopyridine (1.00 g, 6.76 mmol) was dissolved in DMSO (33.8 ml) at room temperature, followed by the addition of CsF (2.053 g, 13.51 mmol). The reaction mixture was stirred in air at 110 °C for 20 hours. After completion of the reaction, the reaction was quenched with water at room temperature and extracted with EtOAc. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous Na2SO4 and subsequently concentrated under reduced pressure. Purification of the residue by column chromatography (silica gel as stationary phase and EtOAc in hexane as eluent) afforded 2-fluoro-3-cyanopyridine (0.639 g, 4.86 mmol, 71.9% yield) as a colorless oil. Compounds 3B'-8B' were prepared by a method similar to the synthetic procedure described above for 2B'.
References
[1] European Journal of Inorganic Chemistry, 2017, vol. 2017, # 2, p. 330 - 339
[2] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
[3] Heterocycles, 1992, vol. 34, # 8, p. 1507 - 1510
[4] Organic Letters, 2015, vol. 17, # 8, p. 1866 - 1869
[5] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145
3-Cyano-2-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Cyano-2-fluoropyridine manufacturers
- Product
- 3-Cyano-2-fluoropyridine 3939-13-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-04-30
- Product
- 3-Cyano-2-fluoropyridine 3939-13-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 3-Cyano-2-fluoropyridine 3939-13-7
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-10