ChemicalBook > CAS DataBase List > p-Trifluoromethoxy phenol
p-Trifluoromethoxy phenol
Uses- Product Name
- p-Trifluoromethoxy phenol
- CAS No.
- 828-27-3
- Chemical Name
- p-Trifluoromethoxy phenol
- Synonyms
- 4-(TRIFLUOROMETHOXY)PHENOL;TFMOPO;uoromethoxy)phenoL;TIMTEC-BB SBB006554;p-Trifluoromethoxy p;4-trifluoroMethoxylphenol;p-(Triflourmethoxy)phenol;P-(TRIFLUOROMETHOXY)PHENOL;PHENOL,4-(TRIFLUOROMETHOXY);4-(TrifluorMethoxy)benzolol
- CBNumber
- CB1268120
- Molecular Formula
- C7H5F3O2
- Formula Weight
- 178.11
- MOL File
- 828-27-3.mol
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p-Trifluoromethoxy phenol Property
- Melting point:
- 17-18°C
- Boiling point:
- 92 °C25 mm Hg(lit.)
- Density
- 1.375 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.447(lit.)
- Flash point:
- 187 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Chloroform, Methanol
- form
- Liquid
- pka
- 9.30±0.13(Predicted)
- Specific Gravity
- 1.375
- color
- Clear brown
- BRN
- 1945934
- InChIKey
- NWVVVBRKAWDGAB-UHFFFAOYSA-N
- CAS DataBase Reference
- 828-27-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Phenol, 4-(trifluoromethoxy)-(828-27-3)
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Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-27-36/37/39
- RIDADR
- 2927
- WGK Germany
- 2
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29095090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 339865
- Product name
- 4-(Trifluoromethoxy)phenol
- Purity
- 98%
- Packaging
- 1g
- Price
- $24
- Updated
- 2023/01/07
Sigma-Aldrich
- Product number
- 339865
- Product name
- 4-(Trifluoromethoxy)phenol
- Purity
- 98%
- Packaging
- 5g
- Price
- $43
- Updated
- 2023/01/07
TCI Chemical
- Product number
- T1341
- Product name
- 4-(Trifluoromethoxy)phenol
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $21
- Updated
- 2025/07/31
TCI Chemical
- Product number
- T1341
- Product name
- 4-(Trifluoromethoxy)phenol
- Purity
- >95.0%(GC)
- Packaging
- 25g
- Price
- $29
- Updated
- 2025/07/31
TRC
- Product number
- T790885
- Product name
- 4-(Trifluoromethoxy)phenol
- Packaging
- 100g
- Price
- $475
- Updated
- 2021/12/16
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p-Trifluoromethoxy phenol Chemical Properties,Usage,Production
Uses
4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.
Chemical Properties
clear brown liquid
Uses
4-(Trifluoromethoxy)phenol is used as a reactant in the preparation of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors.
Uses
4-(Trifluoromethoxy)phenol was employed in the catalytic enantioselective synthesis of esters.
Uses
Intermediates of Liquid Crystals
Synthesis Reference(s)
Journal of Medicinal Chemistry, 25, p. 1097, 1982 DOI: 10.1021/jm00351a018
Synthesis
139301-27-2
828-27-3
General procedure for the synthesis of 4-trifluoromethoxyphenol from 4-trifluoromethoxyphenylboronic acid: In an atypical method, a flask containing 4-trifluoromethoxyphenylboronic acid (100 mg, 0.82 mmol) was taken to which 10 mol% of iron(III) oxide photocatalyst (13.1 mg) and tetrahydrofuran (2 ml) were added. The reaction mixture was stirred in a normal open flask under diffuse sunlight until complete consumption of the feedstock was shown by thin layer chromatography (TLC) detection. Upon completion of the reaction, the reaction was quenched with water and filtered to remove the catalyst. The filtrate was concentrated under vacuum. The crude product was purified by column chromatography on silica gel (100-200 mesh) with an eluent of 15:1 ethyl acetate/hexane, resulting in 73.2 mg (95% yield) of pure crystalline 4-trifluoromethoxyphenol.
References
[1] Tetrahedron Letters, 2014, vol. 55, # 4, p. 811 - 814
[2] Tetrahedron Letters, 2015, vol. 55, # 4, p. 811 - 814
[3] Synthesis (Germany), 2014, vol. 46, # 3, p. 295 - 300
p-Trifluoromethoxy phenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from p-Trifluoromethoxy phenol manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- p-Trifluoromethoxy phenol 828-27-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-25
Chongqing Soarwin Technology Co., Ltd
- Product
- p-Trifluoromethoxy phenol 828-27-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-10
Hebei Zhuanglai Chemical Trading Co Ltd
- Product
- p-Trifluoromethoxy phenol 828-27-3
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-19
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