ML-323
- Product Name
- ML-323
- CAS No.
- 1572414-83-5
- Chemical Name
- ML-323
- Synonyms
- ML-323;ML 3232;CS-1457;ML323, >=98%;ML323; ML 323;ML-323 USP/EP/BP;ML323, 99%, an USP1-UAF1 inhibitor;ML-323,Deubiquitinase,ML 323,Inhibitor,inhibit,DUBs;N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine;5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine
- CBNumber
- CB12682014
- Molecular Formula
- C23H24N6
- Formula Weight
- 384.48
- MOL File
- 1572414-83-5.mol
ML-323 Property
- Boiling point:
- 515.4±60.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 40 mg/ml), or in Ethanol (up to 20 mg/ml)
- form
- solid
- pka
- 5.37±0.10(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety
- HS Code
- 29299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 18010
- Product name
- ML-323
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 18010
- Product name
- ML-323
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $174
- Updated
- 2024/03/01
- Product number
- 18010
- Product name
- ML-323
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- 18010
- Product name
- ML-323
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $719
- Updated
- 2024/03/01
- Product number
- 6435
- Product name
- ML323
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $319
- Updated
- 2021/12/16
ML-323 Chemical Properties,Usage,Production
Description
ML323 (1571424-83-5) is a potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nM in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 μM.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2? ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3
Uses
ML323 is a highly potent and selective USP1-UAF1 inhibitor.
in vitro
studies in h596 cells showed that ml-323 blocked the deubiquitination of pcna and fancd2 via suppressing usp1–uaf1 activity. it was reported that ml-323 potently inhibited usp1-uaf1 with ic50 values of 76 nm and 174 nm in ubiquitin-rhodamine (ub-rho) assay and orthogonal gel-based assay, respectively. in addition, by targeting tls and fa, two major dna damage response pathways, ml-323 increased cisplatin cytotoxicity both in nsclc h596 cells and u2os osteosarcoma cells. moreover, this agent exhibited a high selectivity to human dubs, desumoylase, deneddylase and unrelated proteases. [1]
target
USP1-UAF1
IC 50
ml-323 is a highly potent and selective inhibitor of usp1-uaf1 with ic50 value of 76 nm.
storage
Store at -20°C
References
1) Dexheimer et al. (2014), Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer; J. Med. Chem., 57 8099 2) Liang et al. (2014), A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses; Nat. Chem. Biol., 10 298 3) Lim et al. (2018) USP1 is required for replication fork protection in BRCA1-deficient tumors; Mol. Cell, 72 925
ML-323 Preparation Products And Raw materials
Raw materials
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