ML-7 HYDROCHLORIDE
- Product Name
- ML-7 HYDROCHLORIDE
- CAS No.
- 110448-33-4
- Chemical Name
- ML-7 HYDROCHLORIDE
- Synonyms
- ML-7;CS-755;ML;ML 7;ML-7, HCl;ML-7 HYDROCHLORIDE;ML7;ML 7 HYDROCHLORIDE;ML 7 hydrochloride, >=98%;ML-7 hydrochloride hydrate;1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1,;ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
- CBNumber
- CB9183931
- Molecular Formula
- C15H18ClIN2O2S
- Formula Weight
- 452.74
- MOL File
- 110448-33-4.mol
ML-7 HYDROCHLORIDE Property
- Melting point:
- 246-249°C dec.
- storage temp.
- -20°C
- solubility
- insoluble in EtOH; ≥15.95 mg/mL in DMSO; ≥8.82 mg/mL in H2O with gentle warming and ultrasonic
- form
- powder
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- I2764
- Product name
- ML-7
- Purity
- powder
- Packaging
- 5mg
- Price
- $163
- Updated
- 2024/03/01
- Product number
- 475880
- Product name
- ML-7, Hydrochloride
- Packaging
- 1mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- 11801
- Product name
- ML-7 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 11801
- Product name
- ML-7 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2023/06/20
- Product number
- 11801
- Product name
- ML-7 (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $96
- Updated
- 2024/03/01
ML-7 HYDROCHLORIDE Chemical Properties,Usage,Production
Description
ML-
Chemical Properties
Off-White to Yellow Fine Crystalline Solid
Uses
A potent and selective inhibitor of myosin light chain kinase.
Uses
ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.
Biochem/physiol Actions
Selective myosin light chain kinase inhibitor.
in vitro
rats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].
in vivo
administration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].
storage
room temperature (desiccate)
References
[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.
ML-7 HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
ML-7 HYDROCHLORIDE Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94838
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- Fax
- 021-57711696
- marketing_china@spectrumchemical.com
- Country
- China
- ProdList
- 9664
- Advantage
- 60
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 020-39119399 18927568969
- Fax
- 020-39119999
- isunpharm@qq.com
- Country
- China
- ProdList
- 4428
- Advantage
- 55
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2784
- Advantage
- 58
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 400-1647117 15221909166
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41438
- Advantage
- 60
- Tel
- 021-60345187 13671753212
- Fax
- 021-34702061
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 10287
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2989
- Advantage
- 60
View Lastest Price from ML-7 HYDROCHLORIDE manufacturers
- Product
- ML-7 HYDROCHLORIDE 110448-33-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 200kg
- Release date
- 2019-12-23