ChemicalBook > CAS DataBase List > ML-7 HYDROCHLORIDE

ML-7 HYDROCHLORIDE

Product Name
ML-7 HYDROCHLORIDE
CAS No.
110448-33-4
Chemical Name
ML-7 HYDROCHLORIDE
Synonyms
ML-7;CS-755;ML;ML 7;ML-7, HCl;ML-7 HYDROCHLORIDE;ML7;ML 7 HYDROCHLORIDE;ML 7 hydrochloride, >=98%;ML-7 hydrochloride hydrate;1-(5-iodonaphthalene-1-sulfonyl)-1H-*hexahydro-1,;ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
CBNumber
CB9183931
Molecular Formula
C15H18ClIN2O2S
Formula Weight
452.74
MOL File
110448-33-4.mol
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ML-7 HYDROCHLORIDE Property

Melting point:
246-249°C dec.
storage temp. 
-20°C
solubility 
insoluble in EtOH; ≥15.95 mg/mL in DMSO; ≥8.82 mg/mL in H2O with gentle warming and ultrasonic
form 
powder
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I2764
Product name
ML-7
Purity
powder
Packaging
5mg
Price
$163
Updated
2024/03/01
Sigma-Aldrich
Product number
475880
Product name
ML-7, Hydrochloride
Packaging
1mg
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
11801
Product name
ML-7 (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
11801
Product name
ML-7 (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$31
Updated
2023/06/20
Cayman Chemical
Product number
11801
Product name
ML-7 (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$96
Updated
2024/03/01
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ML-7 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

ML-7 inhibits smooth muscle myosin light chain kinase (MLCK) with a Ki value of 0.3 μM and displays reversible, ATP-competitive inhibition of Ca2+-calmodulin-dependent and -independent smooth muscle MLCKs. It exhibits a 10-fold more potent inhibition of MLCK than its parent compound ML-9 .

Chemical Properties

Off-White to Yellow Fine Crystalline Solid

Uses

A potent and selective inhibitor of myosin light chain kinase.

Uses

ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.

Biochem/physiol Actions

Selective myosin light chain kinase inhibitor.

in vitro

rats with myocardial infarction were intravenously infused with rhnrg-1. the cmlck expression and phosphorylated mlc-2v were up-regulated in rat treated with rhnrg-1 significantly. moreover, the restoration of rhnrg-1-induced sarcomeric organization in serum-free cultured neonatal rat cardiomyocytes with rhnrg-1 was inhibited by ml-7 [1].

in vivo

administration of ml-7 from 10 min before ischemia to the first 10 min of reperfusion led to a significant recovery of heart contractility. gel analyses of two-dimensional electrophoresis revealed eight proteins with decreased levels in i/r hearts. six proteins involved in energy metabolism, which were cytochrome b-c1 complex subunit 1, atp synthase beta subunit, cytochrome c oxidase subunit, mitochondrial nadhdehydrogenase, nadhdehydrogenase iron-sulfur protein 8, and succinyl-coa ligase subunit. the other two protein levels decreased in i/r hearts, which were peroxiredoxin-2 and tubulin. in addition, ml-7 treatment increased the level of succinyl-coa ligase, which was a key enzyme involved in the citric acid cycle [2].

storage

room temperature (desiccate)

References

[1] gu x,liu x,xu d,li x,yan m,qi y,yan w,wang w,pan j,xu y,xi b,cheng l,jia j,wang k,ge j,zhou m. cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin. cardiovasc res.2010 nov 1;88(2):334-43.
[2] lin hb,cadete vj,sawicka j,wozniak m,sawicki g. effect of the myosin light chain kinase inhibitor ml-7 on the proteome of hearts subjected to ischemia-reperfusion injury. j proteomics.2012 sep 18;75(17):5386-95.

ML-7 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ML-7 HYDROCHLORIDE Suppliers

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View Lastest Price from ML-7 HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
ML-7 HYDROCHLORIDE 110448-33-4
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-23

110448-33-4, ML-7 HYDROCHLORIDERelated Search:

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  • ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem
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  • 110448-33-4
  • C15H18ClIN2O2S
  • C15H17N2O2ISHCl
  • C15H17IN2O2SHCl
  • Serine/Threonine Kinase Inhibitors
  • Myosin Light Chain Kinase (MLCK)
  • Kinase/Phosphatase Biology
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • All Inhibitors
  • Inhibitors
  • Protein Kinase Inhibitors and Activators