ML-323
- Product Name
- ML-323
- CAS No.
- 1572414-83-5
- Chemical Name
- ML-323
- Synonyms
- ML-323;ML 3232;CS-1457;ML323, >=98%;ML323; ML 323;ML-323 USP/EP/BP;ML-323, 10 mM in DMSO;USP1-UAF1 Inhibitor, ML323;ML323, 99%, an USP1-UAF1 inhibitor;ML-323,Deubiquitinase,ML 323,Inhibitor,inhibit,DUBs
- CBNumber
- CB12682014
- Molecular Formula
- C23H24N6
- Formula Weight
- 384.48
- MOL File
- 1572414-83-5.mol
ML-323 Property
- Boiling point:
- 515.4±60.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 40 mg/ml), or in Ethanol (up to 20 mg/ml)
- form
- solid
- pka
- 5.37±0.10(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety
- HS Code
- 29299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1177
- Product name
- ML323
- Purity
- ≥98% (HPLC)
- Packaging
- 5 mg
- Price
- $73.5
- Updated
- 2025/07/31
- Product number
- SML1177
- Product name
- ML323
- Purity
- ≥98% (HPLC)
- Packaging
- 25 mg
- Price
- $416
- Updated
- 2025/07/31
- Product number
- 5.31131
- Product name
- USP1-UAF1 Inhibitor, ML323
- Packaging
- 10 mg
- Price
- $284
- Updated
- 2025/07/31
- Product number
- 18010
- Product name
- ML-323
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 18010
- Product name
- ML-323
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $174
- Updated
- 2024/03/01
ML-323 Chemical Properties,Usage,Production
Description
ML323 (1571424-83-5) is a potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nM in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 μM.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2? ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3
Uses
ML323 is a highly potent and selective USP1-UAF1 inhibitor.
in vitro
studies in h596 cells showed that ml-323 blocked the deubiquitination of pcna and fancd2 via suppressing usp1–uaf1 activity. it was reported that ml-323 potently inhibited usp1-uaf1 with ic50 values of 76 nm and 174 nm in ubiquitin-rhodamine (ub-rho) assay and orthogonal gel-based assay, respectively. in addition, by targeting tls and fa, two major dna damage response pathways, ml-323 increased cisplatin cytotoxicity both in nsclc h596 cells and u2os osteosarcoma cells. moreover, this agent exhibited a high selectivity to human dubs, desumoylase, deneddylase and unrelated proteases. [1]
target
USP1-UAF1
IC 50
ml-323 is a highly potent and selective inhibitor of usp1-uaf1 with ic50 value of 76 nm.
storage
Store at -20°C
References
[1] THOMAS S. DEXHEIMER. Synthesis and Structure–Activity Relationship Studies of N-Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer[J]. Journal of Medicinal Chemistry, 2014, 57 19: 8099-8110. DOI:10.1021/jm5010495
[2] QIN LIANG. A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses[J]. Nature chemical biology, 2014, 10 4: 298-304. DOI:10.1038/nchembio.1455
[3] KAH SUAN LIM. USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.[J]. Molecular Cell, 2018, 72 6: 925-941.e4. DOI:10.1016/j.molcel.2018.10.045
ML-323 Preparation Products And Raw materials
Raw materials
Preparation Products
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