ChemicalBook > CAS DataBase List > ML-323

ML-323

Product Name
ML-323
CAS No.
1572414-83-5
Chemical Name
ML-323
Synonyms
ML-323;ML 3232;CS-1457;ML323, >=98%;ML323; ML 323;ML-323 USP/EP/BP;ML323, 99%, an USP1-UAF1 inhibitor;ML-323,Deubiquitinase,ML 323,Inhibitor,inhibit,DUBs;N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine;5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine
CBNumber
CB12682014
Molecular Formula
C23H24N6
Formula Weight
384.48
MOL File
1572414-83-5.mol
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ML-323 Property

Boiling point:
515.4±60.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 40 mg/ml), or in Ethanol (up to 20 mg/ml)
form 
solid
pka
5.37±0.10(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

HS Code 
29299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18010
Product name
ML-323
Purity
≥98%
Packaging
5mg
Price
$92
Updated
2024/03/01
Cayman Chemical
Product number
18010
Product name
ML-323
Purity
≥98%
Packaging
10mg
Price
$174
Updated
2024/03/01
Cayman Chemical
Product number
18010
Product name
ML-323
Purity
≥98%
Packaging
25mg
Price
$384
Updated
2024/03/01
Cayman Chemical
Product number
18010
Product name
ML-323
Purity
≥98%
Packaging
50mg
Price
$719
Updated
2024/03/01
Tocris
Product number
6435
Product name
ML323
Purity
≥98%(HPLC)
Packaging
25
Price
$319
Updated
2021/12/16
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ML-323 Chemical Properties,Usage,Production

Description

ML323 (1571424-83-5) is a potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nM in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 μM.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2? ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3

Uses

ML323 is a highly potent and selective USP1-UAF1 inhibitor.

in vitro

studies in h596 cells showed that ml-323 blocked the deubiquitination of pcna and fancd2 via suppressing usp1–uaf1 activity. it was reported that ml-323 potently inhibited usp1-uaf1 with ic50 values of 76 nm and 174 nm in ubiquitin-rhodamine (ub-rho) assay and orthogonal gel-based assay, respectively. in addition, by targeting tls and fa, two major dna damage response pathways, ml-323 increased cisplatin cytotoxicity both in nsclc h596 cells and u2os osteosarcoma cells. moreover, this agent exhibited a high selectivity to human dubs, desumoylase, deneddylase and unrelated proteases. [1]

target

USP1-UAF1

IC 50

ml-323 is a highly potent and selective inhibitor of usp1-uaf1 with ic50 value of 76 nm.

storage

Store at -20°C

References

1) Dexheimer et al. (2014), Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer; J. Med. Chem., 57 8099 2) Liang et al. (2014), A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses; Nat. Chem. Biol., 10 298 3) Lim et al. (2018) USP1 is required for replication fork protection in BRCA1-deficient tumors; Mol. Cell, 72 925

ML-323 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML-323 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
CEG Chemical Science&Technology Co., Ltd.
Tel
Mobile:13665161512
Fax
+86-510-68873513
Country
China
ProdList
1785
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4456
Advantage
55

1572414-83-5, ML-323Related Search:


  • ML-323
  • 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine
  • 4-Pyrimidinamine, 5-methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-
  • 5-Methyl-2-[2-(1-methylethyl)phenyl]-N-[[4-(1H-1,2,3-triazol-1-yl)phenyl]methyl]-4-pyrimidinamine ML323
  • ML323, >=98%
  • N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine
  • ML323, 99%, an USP1-UAF1 inhibitor
  • 5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amine
  • ML323; ML 323
  • CS-1457
  • ML 3232
  • 2-(2-Isopropylphenyl)-5-methyl-N-{[4-(1,2,3-triazol-1-yl)phenyl]methyl}pyrimidin-4-amine
  • ML-323 USP/EP/BP
  • ML-323,Deubiquitinase,ML 323,Inhibitor,inhibit,DUBs
  • 1572414-83-5
  • C23H24N6
  • Inhibitors