ChemicalBook > CAS DataBase List > IWP L6

IWP L6

Product Name
IWP L6
CAS No.
1427782-89-5
Chemical Name
IWP L6
Synonyms
IWP L6;CS-1445;IWP-L6, >=98%;IWP L6 USP/EP/BP;Porcn Inhibitor III;PORCN INHIBITOR III;IWP-L6;IWP L 6,inhibit,IWP L6,Porcupine,Inhibitor,IWP L-6,Porcn?Inhibitor?III;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
CBNumber
CB92666562
Molecular Formula
C25H20N4O2S2
Formula Weight
472.58
MOL File
1427782-89-5.mol
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IWP L6 Property

storage temp. 
Store at -20° C
solubility 
≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.04819
Product name
Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem
Packaging
10MG
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
15243
Product name
IWP-L6
Purity
≥98%
Packaging
5mg
Price
$82
Updated
2024/03/01
Cayman Chemical
Product number
15243
Product name
IWP-L6
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
15243
Product name
IWP-L6
Purity
≥98%
Packaging
50mg
Price
$561
Updated
2024/03/01
Tocris
Product number
4992
Product name
IWPL6
Purity
≥98%(HPLC)
Packaging
10
Price
$189
Updated
2021/12/16
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IWP L6 Chemical Properties,Usage,Production

Uses

2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide is an inhibitor of Porcupine, a member of the membrane-bound O-acyltransferase family of proteins.

Biological Activity

iwp-l6 is an inhibitor of porcupine with ic50 value of 0.5nm [1].iwp-l6 is developed as a sub-nanomolar inhibitor.of porcupine. it targets the wnt signaling since porcupine is the enzyme to catalyze the palmitoylation of wnt proteins. in hek293 cells, iwp-l6 is found to inhibi the phosphorylation of dishevelled 2 (dvl2) significantly. iwp-l6 has good stability in human plasma but weaker stability in rat and mouse plasma. in vivo assay shows that iwp-l6 is quite active in zebrafish. it blocks the regeneration of the tailfin effectively. it also shows inhibition of posterior axis formation at low micromolar concentrations. additionally, in cultured mouse embryonic kidneys, 10nm iwp-l6 can significantly reduce branching morphogenesis while 50nm iwp-l6 completely blocks wnt signaling [1].

storage

+4°C

References

[1] wang x, moon j, dodge me, pan x, zhang l, hanson jm, tuladhar r, ma z, shi h, williams ns, amatruda jf, carroll tj, lum l, chen c. the development of highly potent inhibitors for porcupine. j med chem. 2013 mar 28;56(6):2700-4.

IWP L6 Preparation Products And Raw materials

Raw materials

Preparation Products

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IWP L6 Suppliers

China 58 India 1 The Netherlands 1 United Kingdom 2 United States 15 Global 77
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4566
Advantage
55
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View Lastest Price from IWP L6 manufacturers

Career Henan Chemical Co
Product
2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide 1427782-89-5
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

1427782-89-5, IWP L6Related Search:

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  • IWP L6
  • 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyriMidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetaMide
  • N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
  • Porcn Inhibitor III
  • N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide IWP-L6
  • 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide
  • CS-1445
  • IWP-L6, >=98%
  • 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl
  • PORCN INHIBITOR III;IWP-L6
  • Acetamide, N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-
  • IWP L6 USP/EP/BP
  • IWP L 6,inhibit,IWP L6,Porcupine,Inhibitor,IWP L-6,Porcn?Inhibitor?III
  • 1427782-89-5
  • Inhibitors