ChemicalBook > CAS DataBase List > IWP L6

IWP L6

Product Name
IWP L6
CAS No.
1427782-89-5
Chemical Name
IWP L6
Synonyms
IWP L6;CS-1445;IWP-L6, >=98%;IWP L6 USP/EP/BP;Porcn Inhibitor III;PORCN INHIBITOR III;IWP-L6;IWP L 6,inhibit,IWP L6,Porcupine,Inhibitor,IWP L-6,Porcn?Inhibitor?III;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
CBNumber
CB92666562
Molecular Formula
C25H20N4O2S2
Formula Weight
472.58
MOL File
1427782-89-5.mol
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IWP L6 Property

storage temp. 
Store at -20° C
solubility 
≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.04819
Product name
Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem
Packaging
10MG
Price
$280
Updated
2024/03/01
Cayman Chemical
Product number
15243
Product name
IWP-L6
Purity
≥98%
Packaging
5mg
Price
$82
Updated
2024/03/01
Cayman Chemical
Product number
15243
Product name
IWP-L6
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
15243
Product name
IWP-L6
Purity
≥98%
Packaging
50mg
Price
$561
Updated
2024/03/01
Tocris
Product number
4992
Product name
IWPL6
Purity
≥98%(HPLC)
Packaging
10
Price
$189
Updated
2021/12/16
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IWP L6 Chemical Properties,Usage,Production

Uses

2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide is an inhibitor of Porcupine, a member of the membrane-bound O-acyltransferase family of proteins.

Biological Activity

iwp-l6 is an inhibitor of porcupine with ic50 value of 0.5nm [1].iwp-l6 is developed as a sub-nanomolar inhibitor.of porcupine. it targets the wnt signaling since porcupine is the enzyme to catalyze the palmitoylation of wnt proteins. in hek293 cells, iwp-l6 is found to inhibi the phosphorylation of dishevelled 2 (dvl2) significantly. iwp-l6 has good stability in human plasma but weaker stability in rat and mouse plasma. in vivo assay shows that iwp-l6 is quite active in zebrafish. it blocks the regeneration of the tailfin effectively. it also shows inhibition of posterior axis formation at low micromolar concentrations. additionally, in cultured mouse embryonic kidneys, 10nm iwp-l6 can significantly reduce branching morphogenesis while 50nm iwp-l6 completely blocks wnt signaling [1].

storage

+4°C

References

[1] wang x, moon j, dodge me, pan x, zhang l, hanson jm, tuladhar r, ma z, shi h, williams ns, amatruda jf, carroll tj, lum l, chen c. the development of highly potent inhibitors for porcupine. j med chem. 2013 mar 28;56(6):2700-4.

IWP L6 Preparation Products And Raw materials

Raw materials

Preparation Products

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IWP L6 Suppliers

China 58 India 1 The Netherlands 1 United Kingdom 2 United States 15 Global 77
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from IWP L6 manufacturers

Career Henan Chemical Co
Product
2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide 1427782-89-5
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

1427782-89-5, IWP L6Related Search:

IWR-1-endo xav-939 LGK-974 Wnt-C59 FH 535 ML-323

  • IWP L6
  • 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyriMidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetaMide
  • N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
  • Porcn Inhibitor III
  • N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide IWP-L6
  • 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide
  • CS-1445
  • IWP-L6, >=98%
  • 2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl
  • PORCN INHIBITOR III;IWP-L6
  • Acetamide, N-(5-phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-
  • IWP L6 USP/EP/BP
  • IWP L 6,inhibit,IWP L6,Porcupine,Inhibitor,IWP L-6,Porcn?Inhibitor?III
  • 1427782-89-5
  • Inhibitors