IWP L6
- Product Name
- IWP L6
- CAS No.
- 1427782-89-5
- Chemical Name
- IWP L6
- Synonyms
- IWP L6;CS-1445;IWP-L6, >=98%;IWP L6 USP/EP/BP;Porcn Inhibitor III;PORCN INHIBITOR III;IWP-L6;IWP L 6,inhibit,IWP L6,Porcupine,Inhibitor,IWP L-6,Porcn?Inhibitor?III;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl;2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide;N-(5-Phenyl-2-pyridinyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]acetamide
- CBNumber
- CB92666562
- Molecular Formula
- C25H20N4O2S2
- Formula Weight
- 472.58
- MOL File
- 1427782-89-5.mol
IWP L6 Property
- storage temp.
- Store at -20° C
- solubility
- ≥22.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
- form
- solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5.04819
- Product name
- Porcn Inhibitor III, IWP-L6 - CAS 1427782-89-6 - Calbiochem
- Packaging
- 10MG
- Price
- $280
- Updated
- 2024/03/01
- Product number
- 15243
- Product name
- IWP-L6
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $82
- Updated
- 2024/03/01
- Product number
- 15243
- Product name
- IWP-L6
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 15243
- Product name
- IWP-L6
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $561
- Updated
- 2024/03/01
- Product number
- 4992
- Product name
- IWPL6
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $189
- Updated
- 2021/12/16
IWP L6 Chemical Properties,Usage,Production
Uses
2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide is an inhibitor of Porcupine, a member of the membrane-bound O-acyltransferase family of proteins.
Biological Activity
iwp-l6 is an inhibitor of porcupine with ic50 value of 0.5nm [1].iwp-l6 is developed as a sub-nanomolar inhibitor.of porcupine. it targets the wnt signaling since porcupine is the enzyme to catalyze the palmitoylation of wnt proteins. in hek293 cells, iwp-l6 is found to inhibi the phosphorylation of dishevelled 2 (dvl2) significantly. iwp-l6 has good stability in human plasma but weaker stability in rat and mouse plasma. in vivo assay shows that iwp-l6 is quite active in zebrafish. it blocks the regeneration of the tailfin effectively. it also shows inhibition of posterior axis formation at low micromolar concentrations. additionally, in cultured mouse embryonic kidneys, 10nm iwp-l6 can significantly reduce branching morphogenesis while 50nm iwp-l6 completely blocks wnt signaling [1].
storage
+4°C
References
[1] wang x, moon j, dodge me, pan x, zhang l, hanson jm, tuladhar r, ma z, shi h, williams ns, amatruda jf, carroll tj, lum l, chen c. the development of highly potent inhibitors for porcupine. j med chem. 2013 mar 28;56(6):2700-4.
IWP L6 Preparation Products And Raw materials
Raw materials
Preparation Products
IWP L6 Suppliers
View Lastest Price from IWP L6 manufacturers
- Product
- 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide 1427782-89-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-01